Astros vs. Angels Prediction, Odds, Picks - September 1

Jeremy Pena and the Houston Astros will try to do damage against Yusei Kikuchi when he takes the mound for the Los Angeles Angels on Monday at 2:10 p.m. ET, in the final game of a four-game series at Daikin Park. The favored Astros have -162 moneyline odds to win against the underdog Angels, who are listed at +136. Houston is favored on the run line (-1.5). The over/under is 8.5 runs for this game.

Take a look at everything you need to know from a betting perspective on the Astros-Angels game, regarding the run line, moneyline and total, plus expert picks.

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Angels vs. Astros Highlights | MLB on FOX

Check out the best moments between the Los Angeles Angels and the Houston Astros.

Astros vs. Angels Game Information & Odds

• When: Monday, September 1, 2025 at 2:10 p.m. ET
• Where: Daikin Park in Houston, Texas
• How to watch on TV: SCHN and FDSW

Astros vs. Angels Prediction

• Score Prediction: Astros 5, Angels 4
• Total Prediction: Over 8.5 runs
• Win Probabilities: Astros 60%, Angels 40%

Astros vs. Angels Betting Insights

• This season, the Astros have been favored 93 times and won 49, or 52.7%, of those games.
• This season Houston has won 14 of its 28 games, or 50%, when favored by at least -162 on the moneyline.
• The implied probability of a win from the Astros, based on the moneyline, is 61.8%.
• The Angels have been underdogs in 103 games this season and have come away with the win 47 times (45.6%) in those contests.
• Los Angeles has a mark of 24-24 in contests where bookmakers favor it by +136 or worse on the moneyline.
• Bookmakers have implied with the moneyline set for this matchup that the Angels have a 42.4% chance of pulling out a win.

Astros Recent Betting Performance

• The Astros went 4-3 over the seven games they were favored on the moneyline in their last 10 matchups.
• In their last 10 outings, the Astros and their opponents combined to go over the run total three times (all 10 of the games had set totals).
• The Astros are 6-4-0 against the spread over their past 10 games.

Astros Recent Stats

Astros Player Insights

• Jose Altuve has gone yard 23 times this season, the highest mark on the Astros, while hitting .273 with 65 RBI.
• Altuve is 38th in home runs and 67th in RBI among all hitters in baseball.
• Jeremy Pena's .305 batting average leads his team.
• Pena ranks 125th in home runs and 136th in RBI on the season.
• Christian Walker paces the Astros with 74 runs batted in.
• Yainer Diaz is batting .253 with 17 doubles, a triple, 18 home runs and 19 walks.

Astros Team Props

Angels Recent Betting Performance

• In nine games as underdogs over the last 10 matchups, the Angels have a record of 3-6.
• When it comes to hitting the over, the Angels and their opponents are 3-7-0 in their last 10 games with a total.
• The Angels have a record of 5-5-0 ATS over their last 10 games.

Angels Recent Stats

Angels Player Insights

• Taylor Ward paces the Angels in home runs (30) and runs batted in (94).
• In all of MLB, Ward is 10th in home runs and seventh in RBI.
• Zach Neto has 29 doubles, a triple, 24 home runs and 29 walks while hitting .265.
• Neto is 36th in homers and 95th in RBI among all MLB hitters this season.
• Jo Adell has 30 home runs, best in the lineup.
• Mike Trout is hitting .231 with 12 doubles, a triple, 20 home runs and 75 walks.

Angels Team Props

Angels vs. Astros Highlights | MLB on FOX

Check out the best moments between the Los Angeles Angels and the Houston Astros.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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