Vanderbilt vs. Missouri Prediction, Odds, Picks - October 25, 2025

Updated Oct. 25, 2025 3:04 p.m. ET

FOX Sports

The No. 10 Vanderbilt Commodores (6-1) and the 12th-ranked run defense will host the No. 15 Missouri Tigers (6-1) and the seventh-ranked run offense on Saturday, October 25, 2025. The Tigers are 3-point underdogs. A 53-point over/under is set for the contest.

The Commodores won versus the LSU Tigers in their most recent game, 31-24. The Tigers' last contest was versus the Auburn Tigers, and they won by a score of 23-17.

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Vanderbilt vs. Missouri Game Information & Odds

When: Saturday, October 25, 2025 at 3:30 p.m. ET
Location: FirstBank Stadium in Nashville, Tennessee
TV: ESPN
Live Box Score on FOX Sports

Vanderbilt vs Missouri Betting Information updated as of October 25, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Vanderbilt	-3 (-116)	-158	+133	53	-110	-110

Vanderbilt vs. Missouri Prediction

Pick ATS: Vanderbilt (-3)
Pick OU: Over (53)
Prediction: Vanderbilt 34, Missouri 25

Predictions are made by the Data Skrive betting model.

Learn more about the Vanderbilt Commodores vs. the Missouri Tigers game on FOX Sports!

Vanderbilt vs. Missouri Betting Insights

Per the spread and over/under, the implied score for the matchup is Commodores 28, Tigers 25.
The Commodores have a 61.2% chance to claim victory in this contest per the moneyline's implied probability. The Tigers have a 42.9% implied probability.
Vanderbilt has compiled a 5-2-0 ATS record so far this year.
Missouri has compiled a 5-2-0 record against the spread this year.

Vanderbilt vs. Missouri: Head-to-Head

Over their last four meetings, Missouri has four wins versus Vanderbilt.
In those games versus Missouri, the Commodores have covered three times while going over the point total on three occasions.
Vanderbilt has been outpaced by 32 points in its last four tilts against Missouri.

Vanderbilt vs. Missouri: 2025 Stats Comparison

	Vanderbilt	Missouri
Off. Points per Game (Rank)	41.4 (8)	39 (13)
Def. Points per Game (Rank)	20 (36)	16.7 (16)
Turnovers Allowed (Rank)	6 (21)	8 (56)
Turnovers Forced (Rank)	10 (40)	6 (99)

Vanderbilt 2025 Key Players

Name	Position	Stats
Diego Pavia	QB	1,569 YDS (70.5%) / 15 TD / 4 INT 438 RUSH YDS / 4 RUSH TD / 62.6 RUSH YPG
Sedrick Alexander	RB	364 YDS / 6 TD / 52 YPG / 5.7 YPC 10 REC / 105 REC YDS / 4 REC TD / 15 REC YPG
Junior Sherrill	WR	25 REC / 304 YDS / 5 TD / 43.4 YPG
Makhilyn Young	RB	293 YDS / 4 TD / 41.9 YPG / 11.3 YPC 6 REC / 43 REC YDS / 0 REC TD / 10.8 REC YPG
Miles Capers	DL	17 TKL / 5 TFL / 4.5 SACK
CJ Heard	DB	31 TKL / 1 TFL / 1 SACK / 1 INT
Zaylin Wood	DL	14 TKL / 3 TFL / 3 SACK / 1 INT
Khordae Sydnor	DL	15 TKL / 4 TFL / 2.5 SACK

Missouri 2025 Key Players

Name	Position	Stats
Ahmad Hardy	RB	840 YDS / 11 TD / 120 YPG / 6 YPC
Beau Pribula	QB	1,622 YDS (70%) / 11 TD / 7 INT 210 RUSH YDS / 5 RUSH TD / 30 RUSH YPG
Jamal Roberts	RB	406 YDS / 3 TD / 58 YPG / 7.3 YPC 11 REC / 111 REC YDS / 1 REC TD / 18.5 REC YPG
Brett Norfleet	TE	25 REC / 221 YDS / 5 TD / 31.6 YPG
Zion Young	DL	23 TKL / 6 TFL / 5 SACK
Josiah Trotter	LB	42 TKL / 7 TFL / 1 SACK
Damon Wilson Jr.	DL	11 TKL / 5 TFL / 5.5 SACK
Khalil Jacobs	LB	22 TKL / 4 TFL / 3 SACK