USC vs. Michigan Prediction, Odds, Picks - October 11, 2025

The USC Trojans (4-1) are just 2.5-point favorites at home at Los Angeles Memorial Coliseum against the No. 15 Michigan Wolverines (4-1) on Saturday, October 11, 2025. Both teams have high-powered running games, with the Trojans 17th in rushing yards per game, and the Wolverines 12th. The over/under is set at 56.5.

In their last action, the Trojans lost against the Illinois Fighting Illini, 34-32. The Wolverines beat the Wisconsin Badgers, 24-10, in their most recent contest.

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USC vs. Michigan Game Information & Odds

• When: Saturday, October 11, 2025 at 7:30 p.m. ET
• Location: Los Angeles Memorial Coliseum in Los Angeles, California
• TV: NBC
• Live Box Score on FOX Sports

USC vs. Michigan Prediction

• Pick ATS: Michigan (+2.5)
  
• Pick OU: Over (56.5)
  
• Prediction: USC 31, Michigan 29

Predictions are made by the Data Skrive betting model.

Learn more about the USC Trojans vs. the Michigan Wolverines game on FOX Sports!

USC vs. Michigan Betting Insights

• Per the spread and over/under, the implied score for the matchup is Trojans 30, Wolverines 27.
• The Trojans have a 58.8% chance to claim victory in this contest per the moneyline's implied probability. The Wolverines have a 45.5% implied probability.
• USC has won two games against the spread this season.
• Michigan has won two games against the spread this season.

USC vs. Michigan: 2025 Stats Comparison

USC 2025 Key Players

Michigan 2025 Key Players

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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