USC vs. Michigan Prediction, Odds, Picks - October 11, 2025

Updated Oct. 11, 2025 3:04 p.m. ET

Data Skrive

The USC Trojans (4-1) are just 2.5-point favorites at home at Los Angeles Memorial Coliseum against the No. 15 Michigan Wolverines (4-1) on Saturday, October 11, 2025. Both teams have high-powered running games, with the Trojans 17th in rushing yards per game, and the Wolverines 12th. The over/under is set at 56.5.

In their last action, the Trojans lost against the Illinois Fighting Illini, 34-32. The Wolverines beat the Wisconsin Badgers, 24-10, in their most recent contest.

Keep up with college football all season on FOX Sports.

USC vs. Michigan Game Information & Odds

When: Saturday, October 11, 2025 at 7:30 p.m. ET
Location: Los Angeles Memorial Coliseum in Los Angeles, California
TV: NBC
Live Box Score on FOX Sports

USC vs Michigan Betting Information updated as of October 11, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
USC	-2.5 (-115)	-143	+120	56.5	-108	-112

USC vs. Michigan Prediction

Pick ATS: Michigan (+2.5)
Pick OU: Over (56.5)
Prediction: USC 31, Michigan 29

Predictions are made by the Data Skrive betting model.

Learn more about the USC Trojans vs. the Michigan Wolverines game on FOX Sports!

USC vs. Michigan Betting Insights

Per the spread and over/under, the implied score for the matchup is Trojans 30, Wolverines 27.
The Trojans have a 58.8% chance to claim victory in this contest per the moneyline's implied probability. The Wolverines have a 45.5% implied probability.
USC has won two games against the spread this season.
Michigan has won two games against the spread this season.

USC vs. Michigan: 2025 Stats Comparison

	USC	Michigan
Off. Points per Game (Rank)	48.4 (8)	32.8 (58)
Def. Points per Game (Rank)	23 (51)	16.2 (20)
Turnovers Allowed (Rank)	5 (35)	3 (9)
Turnovers Forced (Rank)	9 (22)	9 (22)

USC 2025 Key Players

Name	Position	Stats
Jayden Maiava	QB	1,587 YDS (70.5%) / 11 TD / 1 INT 57 RUSH YDS / 4 RUSH TD / 11.4 RUSH YPG
Makai Lemon	WR	35 REC / 589 YDS / 5 TD / 117.8 YPG
Waymond Jordan	RB	537 YDS / 5 TD / 107.4 YPG / 7 YPC
Eli Sanders	RB	264 YDS / 2 TD / 52.8 YPG / 5.6 YPC 7 REC / 115 REC YDS / 1 REC TD / 23 REC YPG
Eric Gentry	LB	17 TKL / 4 TFL / 3 SACK
Bishop Fitzgerald	DB	9 TKL / 0 TFL / 3 INT / 3 PD
Braylan Shelby	DL	5 TKL / 3 TFL / 3.5 SACK
Kameryn Fountain	DL	5 TKL / 3 TFL / 2.5 SACK

Michigan 2025 Key Players

Name	Position	Stats
Justice Haynes	RB	654 YDS / 8 TD / 130.8 YPG / 7.7 YPC
Bryce Underwood	QB	1,003 YDS (59.2%) / 3 TD / 1 INT 181 RUSH YDS / 3 RUSH TD / 36.2 RUSH YPG
Jordan Marshall	RB	233 YDS / 3 TD / 46.6 YPG / 5.2 YPC
Donaven McCulley	WR	19 REC / 309 YDS / 1 TD / 61.8 YPG
Cole Sullivan	LB	14 TKL / 3 TFL / 2 SACK / 2 INT
Jaishawn Barham	LB	13 TKL / 4 TFL / 3 SACK
Jimmy Rolder	LB	18 TKL / 1 TFL / 1 SACK
Derrick Moore	DL	8 TKL / 2 TFL / 2.5 SACK