TCU vs. SMU Prediction, Odds, Picks - September 20, 2025

Updated Sep. 20, 2025 9:04 a.m. ET

Data Skrive

The TCU Horned Frogs (2-0) and the SMU Mustangs (2-1) meet with the Iron Skillet on the line on Saturday, September 20, 2025 at Amon G. Carter Stadium. The Horned Frogs are favored by 6.5 points in the outing. The over/under is set at 63.5 points for the outing.

The Horned Frogs won against the Abilene Christian Wildcats in their most recent game, 42-21. The Mustangs won against the Missouri State Bears in their last game, 28-10.

Keep up with college football all season on FOX Sports.

TCU vs. SMU Game Information & Odds

When: Saturday, September 20, 2025 at 12 p.m. ET
Location: Amon G. Carter Stadium in Fort Worth, Texas
TV: ESPN2
Live Box Score on FOX Sports

TCU vs SMU Betting Information updated as of September 20, 2025, 8:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
TCU	-6.5 (-112)	-244	+198	63.5	-112	-108

TCU vs. SMU Prediction

Pick ATS: TCU (-6.5)
Pick OU: Over (63.5)
Prediction: TCU 39, SMU 25

Predictions are made by the Data Skrive betting model.

Learn more about the TCU Horned Frogs vs. the SMU Mustangs game on FOX Sports!

TCU vs. SMU Betting Insights

Based on the spread and over/under, the implied score for the tilt is Horned Frogs 35, Mustangs 28.
The Horned Frogs have a 70.9% chance to claim victory in this meeting per the moneyline's implied probability. The Mustangs hold a 33.6% implied probability.
TCU has a record of 1-1-0 against the spread this season.
SMU is winless against the spread this year (0-2-0).

TCU vs. SMU: Head-to-Head

TCU and SMU have been matched up evenly over their last four matchups, sharing the same 2-2 record.
The two teams have gone over the total on three occasions while sharing a split 2-2 record in their matchups against the spread.
Over their last four head-to-head contests, SMU has racked up 159 points, while TCU has tallied 152.

TCU vs. SMU: 2025 Stats Comparison

	TCU	SMU
Off. Points per Game (Rank)	45 (67)	38.3 (34)
Def. Points per Game (Rank)	17.5 (23)	23.7 (81)
Turnovers Allowed (Rank)	2 (27)	6 (117)
Turnovers Forced (Rank)	3 (69)	8 (1)

TCU 2025 Key Players

Name	Position	Stats
Josh Hoover	QB	621 YDS (76.2%) / 6 TD / 1 INT
Jordan Dwyer	WR	14 REC / 225 YDS / 2 TD / 112.5 YPG
Kevorian Barnes	RB	156 YDS / 1 TD / 78 YPG / 7.4 YPC 4 REC / 28 REC YDS / 0 REC TD / 14 REC YPG
Trent Battle	RB	48 YDS / 2 TD / 24 YPG / 9.6 YPC
Ansel Din-Mbuh	DL	4 TKL / 2 TFL / 1.5 SACK
Kylin Jackson	DB	4 TKL / 2 TFL / 1 SACK
Zachary Chapman	DL	1 TKL / 1 TFL / 1 SACK
Namdi Obiazor	LB	4 TKL / 1 TFL / 1 SACK

SMU 2025 Key Players

Name	Position	Stats
Kevin Jennings	QB	836 YDS (70.5%) / 6 TD / 3 INT 17 RUSH YDS / 1 RUSH TD / 5.7 RUSH YPG
Tomarion Harden	RB	253 YDS / 5 TD / 84.3 YPG / 6 YPC
Romello Brinson	WR	15 REC / 314 YDS / 3 TD / 104.7 YPG
Jalen Cooper	WR	12 REC / 230 YDS / 2 TD / 76.7 YPG
Cam Robertson	DL	8 TKL / 2 TFL / 2 SACK
Ahmaad Moses	DB	11 TKL / 1 TFL / 1 SACK / 1 INT
Jeffrey M'ba	DL	4 TKL / 2 TFL / 2.5 SACK
Isaiah Nwokobia	DB	9 TKL / 0 TFL / 1 INT / 1 PD