Syracuse vs. UConn Prediction, Odds, Picks - September 6, 2025

Updated Sep. 6, 2025 9:04 a.m. ET

FOX Sports

The UConn Huskies (1-0) will try to defy oddsmakers when they square off against the Syracuse Orange (0-1) on Saturday, September 6, 2025 as 6.5-point underdogs. An over/under of 57.5 is set for the game.

The Orange lost to the Tennessee Volunteers, 45-26, in their last contest. In their last contest, the Huskies won against the Central Connecticut State Blue Devils, 59-13.

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Syracuse vs. UConn Game Information & Odds

When: Saturday, September 6, 2025 at 12 p.m. ET
Location: JMA Wireless Dome in Syracuse, New York
TV: ACC Network Extra
Live Box Score on FOX Sports

Syracuse vs UConn Betting Information updated as of September 6, 2025, 8:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Syracuse	-6.5 (-120)	-259	+211	57.5	-105	-115

Syracuse vs. UConn Prediction

Pick ATS: Syracuse (-6.5)
Pick OU: Over (57.5)
Prediction: Syracuse 35, UConn 23

Predictions are made by the Data Skrive betting model.

Learn more about the Syracuse Orange vs. the UConn Huskies game on FOX Sports!

Syracuse vs. UConn Betting Insights

Based on the spread and over/under, the implied score for the tilt is Orange 32, Huskies 26.
The Orange have a 72.1% chance to collect the win in this contest based on the moneyline's implied probability. The Huskies hold a 32.2% implied probability.
Syracuse is winless against the spread this season (0-1-0).
UConn has a record of 1-0-0 against the spread this season.

Syracuse vs. UConn: Head-to-Head

In their past two head-to-head meetings, Syracuse has won against UConn two times.
In their past two head-to-head meetings, each team has covered one time while both games outscored the point total.
Over their last two head-to-head matchups, Syracuse has put up 79 points, while UConn has accumulated 38.

Syracuse vs. UConn: 2025 Stats Comparison

	Syracuse	UConn
Off. Points per Game (Rank)	26 (77)	59 (13)
Def. Points per Game (Rank)	45 (123)	13 (50)
Turnovers Allowed (Rank)	2 (100)	0 (1)
Turnovers Forced (Rank)	1 (51)	0 (94)

Syracuse 2025 Key Players

Name	Position	Stats
Yasin Willis	RB	91 YDS / 3 TD / 91 YPG / 4 YPC
Johntay Cook II	WR	6 REC / 58 YDS / 1 TD / 58 YPG
Steve Angeli	QB	274 YDS (57.5%) / 1 TD / 1 INT
Will Nixon	RB	33 YDS / 0 TD / 33 YPG / 3.7 YPC 2 REC / 29 REC YDS / 0 REC TD / 29 REC YPG
David Reese	DL	5 TKL / 1 TFL
Darian Chestnut	DB	10 TKL / 0 TFL
Chris Peal	DB	6 TKL / 0 TFL
Gary Bryant III	LB	6 TKL / 0 TFL

UConn 2025 Key Players

Name	Position	Stats
Joe Fagnano	QB	260 YDS (72%) / 3 TD / 0 INT 0 RUSH YDS / 1 RUSH TD / 0 RUSH YPG
Skyler Bell	WR	4 REC / 135 YDS / 2 TD / 135 YPG
Cam Edwards	RB	115 YDS / 1 TD / 115 YPG / 19.2 YPC
Jackson Harper	WR	5 REC / 42 YDS / 1 TD / 42 YPG
Bryun Parham	LB	2 TKL / 1 TFL / 1 SACK
Oumar Diomande	LB	3 TKL / 0 TFL
Donovan Branch	LB	2 TKL / 0 TFL
Marquis Black	DL	1 TKL / 1 TFL