Syracuse vs. UConn Prediction, Odds, Picks - September 6, 2025

The UConn Huskies (1-0) will try to defy oddsmakers when they square off against the Syracuse Orange (0-1) on Saturday, September 6, 2025 as 6.5-point underdogs. An over/under of 57.5 is set for the game.

The Orange lost to the Tennessee Volunteers, 45-26, in their last contest. In their last contest, the Huskies won against the Central Connecticut State Blue Devils, 59-13.

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Syracuse vs. UConn Game Information & Odds

• When: Saturday, September 6, 2025 at 12 p.m. ET
• Location: JMA Wireless Dome in Syracuse, New York
• TV: ACC Network Extra
• Live Box Score on FOX Sports

Syracuse vs. UConn Prediction

• Pick ATS: Syracuse (-6.5)
  
• Pick OU: Over (57.5)
  
• Prediction: Syracuse 35, UConn 23

Predictions are made by the Data Skrive betting model.

Learn more about the Syracuse Orange vs. the UConn Huskies game on FOX Sports!

Syracuse vs. UConn Betting Insights

• Based on the spread and over/under, the implied score for the tilt is Orange 32, Huskies 26.
• The Orange have a 72.1% chance to collect the win in this contest based on the moneyline's implied probability. The Huskies hold a 32.2% implied probability.
• Syracuse is winless against the spread this season (0-1-0).
• UConn has a record of 1-0-0 against the spread this season.

Syracuse vs. UConn: Head-to-Head

• In their past two head-to-head meetings, Syracuse has won against UConn two times.
• In their past two head-to-head meetings, each team has covered one time while both games outscored the point total.
• Over their last two head-to-head matchups, Syracuse has put up 79 points, while UConn has accumulated 38.

Syracuse vs. UConn: 2025 Stats Comparison

Syracuse 2025 Key Players

UConn 2025 Key Players

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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