South Florida vs. Old Dominion Prediction, Odds, Picks - December 17, 2025

Updated Dec. 17, 2025 3:04 p.m. ET

Data Skrive

The Cure Bowl features a battle between the South Florida Bulls (who are 3.5-point favorites) and the Old Dominion Monarchs on December 17, 2025 at 5 p.m. ET on ESPN. The total for this matchup has been set at 52.5 points.

The Bulls' most recent contest was against the Rice Owls, and they won by a score of 52-3. Against the Georgia State Panthers in their last contest, the Monarchs won 27-10.

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South Florida vs. Old Dominion Game Information & Odds

When: Wednesday, December 17, 2025 at 5 p.m. ET
Location: Camping World Stadium in Orlando, Florida
TV: ESPN
Streaming: FOX One + ESPN Bundle

South Florida vs Old Dominion Betting Information updated as of December 17, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
South Florida	-3.5 (-120)	-189	+157	52.5	-112	-108

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South Florida vs. Old Dominion Prediction

Pick ATS: South Florida (-3.5)
Pick OU: Over (52.5)
Prediction: South Florida 34, Old Dominion 24

Predictions are made by the Data Skrive betting model.

Learn more about the South Florida Bulls vs. the Old Dominion Monarchs game on FOX Sports!

South Florida vs. Old Dominion Betting Insights

Based on the spread and over/under, the implied score for the matchup is Bulls 28, Monarchs 24.
The Bulls have a 65.4% chance to collect the win in this meeting based on the moneyline's implied probability. The Monarchs have a 38.9% implied probability.
South Florida has won eight games against the spread this season, while failing to cover or pushing four times.
Old Dominion has covered seven times in 12 matchups with a spread this season.

South Florida vs. Old Dominion: 2025 Stats Comparison

	South Florida	Old Dominion
Off. Points per Game (Rank)	43 (4)	32.7 (35)
Def. Points per Game (Rank)	23.3 (54)	19.3 (18)
Turnovers Allowed (Rank)	15 (63)	23 (126)
Turnovers Forced (Rank)	24 (8)	21 (17)

South Florida 2025 Key Players

Name	Position	Stats
Byrum Brown	QB	3,158 YDS (66.3%) / 28 TD / 7 INT 1,008 RUSH YDS / 14 RUSH TD / 84 RUSH YPG
Keshaun Singleton	WR	50 REC / 877 YDS / 8 TD / 73.1 YPG
Nykahi Davenport	RB	603 YDS / 7 TD / 60.3 YPG / 6.6 YPC 3 REC / 37 REC YDS / 0 REC TD / 12.3 REC YPG
Jeremiah Koger	WR	34 REC / 529 YDS / 7 TD / 52.9 YPG
Mac Harris	LB	90 TKL / 5 TFL / 6 SACK / 2 INT
Jhalyn Shuler	LB	85 TKL / 4 TFL / 1.5 SACK / 1 INT
Jarvis Lee Jr.	DB	42 TKL / 7 TFL / 3 SACK / 2 INT
Fred Gaskin	DB	40 TKL / 2 TFL / 1 SACK / 2 INT

Old Dominion 2025 Key Players

Name	Position	Stats
Colton Joseph	QB	2,624 YDS (59.7%) / 21 TD / 10 INT 1,010 RUSH YDS / 13 RUSH TD / 84.2 RUSH YPG
Trequan Jones	RB	736 YDS / 5 TD / 66.9 YPG / 7.6 YPC
Tre' Brown III	WR	37 REC / 751 YDS / 4 TD / 62.6 YPG
Ja'Cory Thomas	WR	38 REC / 674 YDS / 5 TD / 61.3 YPG
Jeremy Mack Jr.	LB	29 TKL / 4 TFL / 4.5 SACK / 1 INT
Jerome Carter	DB	41 TKL / 1 TFL / 4 INT / 4 PD
Seth Naotala	LB	39 TKL / 3 TFL / 2.5 SACK / 1 INT
Jackson Forrest	LB	25 TKL / 1 TFL / 3.5 SACK