SMU vs. Syracuse Prediction, Odds, Picks - October 4, 2025

The Syracuse Orange (3-2) are 17.5-point underdogs in a road ACC matchup with the SMU Mustangs (2-2) on Saturday, October 4, 2025 at Gerald J. Ford Stadium. The contest has an over/under of 57.5.

Against the TCU Horned Frogs in their last game, the Mustangs lost 35-24. The Orange lost against the Duke Blue Devils in their most recent game, 38-3.

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SMU vs. Syracuse Game Information & Odds

• When: Saturday, October 4, 2025 at 3:30 p.m. ET
• Location: Gerald J. Ford Stadium in University Park, Texas
• TV: ACC Network
• Live Box Score on FOX Sports

SMU vs. Syracuse Prediction

• Pick ATS: Syracuse (+17.5)
  
• Pick OU: Over (57.5)
  
• Prediction: SMU 34, Syracuse 25

Predictions are made by the Data Skrive betting model.

Learn more about the SMU Mustangs vs. the Syracuse Orange game on FOX Sports!

SMU vs. Syracuse Betting Insights

• Based on the spread and over/under, the implied score for the game is Mustangs 38, Orange 20.
• The Mustangs have an 89.0% chance to claim victory in this game based on the moneyline's implied probability. The Orange have a 15.3% implied probability.
• SMU has compiled a 0-3-0 record against the spread this season.
• Syracuse has covered twice in five games with a spread this season.

SMU vs. Syracuse: 2025 Stats Comparison

SMU 2025 Key Players

Syracuse 2025 Key Players

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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