SMU vs. Syracuse Prediction, Odds, Picks - October 4, 2025

Updated Oct. 4, 2025 3:04 p.m. ET

FOX Sports

The Syracuse Orange (3-2) are 17.5-point underdogs in a road ACC matchup with the SMU Mustangs (2-2) on Saturday, October 4, 2025 at Gerald J. Ford Stadium. The contest has an over/under of 57.5.

Against the TCU Horned Frogs in their last game, the Mustangs lost 35-24. The Orange lost against the Duke Blue Devils in their most recent game, 38-3.

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SMU vs. Syracuse Game Information & Odds

When: Saturday, October 4, 2025 at 3:30 p.m. ET
Location: Gerald J. Ford Stadium in University Park, Texas
TV: ACC Network
Live Box Score on FOX Sports

SMU vs Syracuse Betting Information updated as of October 4, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
SMU	-17.5 (-110)	-806	+554	57.5	-106	-119

SMU vs. Syracuse Prediction

Pick ATS: Syracuse (+17.5)
Pick OU: Over (57.5)
Prediction: SMU 34, Syracuse 25

Predictions are made by the Data Skrive betting model.

Learn more about the SMU Mustangs vs. the Syracuse Orange game on FOX Sports!

SMU vs. Syracuse Betting Insights

Based on the spread and over/under, the implied score for the game is Mustangs 38, Orange 20.
The Mustangs have an 89.0% chance to claim victory in this game based on the moneyline's implied probability. The Orange have a 15.3% implied probability.
SMU has compiled a 0-3-0 record against the spread this season.
Syracuse has covered twice in five games with a spread this season.

SMU vs. Syracuse: 2025 Stats Comparison

	SMU	Syracuse
Off. Points per Game (Rank)	34.8 (64)	31.2 (36)
Def. Points per Game (Rank)	26.5 (64)	29.6 (116)
Turnovers Allowed (Rank)	8 (114)	9 (120)
Turnovers Forced (Rank)	9 (10)	6 (51)

SMU 2025 Key Players

Name	Position	Stats
Kevin Jennings	QB	1,126 YDS (68.3%) / 9 TD / 5 INT 30 RUSH YDS / 1 RUSH TD / 7.5 RUSH YPG
Tomarion Harden	RB	309 YDS / 5 TD / 77.3 YPG / 5.4 YPC 5 REC / 24 REC YDS / 0 REC TD / 12 REC YPG
Romello Brinson	WR	19 REC / 365 YDS / 3 TD / 91.3 YPG
Jalen Cooper	WR	13 REC / 243 YDS / 2 TD / 60.8 YPG
Cam Robertson	DL	14 TKL / 3 TFL / 3 SACK
Ahmaad Moses	DB	17 TKL / 1 TFL / 1 SACK / 1 INT
Jeffrey M'ba	DL	9 TKL / 3 TFL / 3 SACK
Isaiah Nwokobia	DB	19 TKL / 0 TFL / 1 INT / 1 PD

Syracuse 2025 Key Players

Name	Position	Stats
Steve Angeli	QB	1,352 YDS (62.8%) / 10 TD / 2 INT -32 RUSH YDS / 1 RUSH TD / -8 RUSH YPG
Yasin Willis	RB	296 YDS / 4 TD / 74 YPG / 4.7 YPC
Justus Ross-Simmons	WR	16 REC / 236 YDS / 5 TD / 47.2 YPG
Darrell Gill Jr.	WR	16 REC / 329 YDS / 3 TD / 65.8 YPG
Braheem Long Jr.	DB	18 TKL / 2 TFL / 2 SACK / 1 INT
Demetres Samuel Jr.	DB	24 TKL / 0 TFL / 1 INT / 1 PD
Antoine Deslauriers	LB	20 TKL / 1 TFL / 1 SACK
Darian Chestnut	DB	25 TKL / 0 TFL