Rice vs. Charlotte Prediction, Odds, Picks - September 18, 2025

Updated Sep. 18, 2025 3:04 p.m. ET

FOX Sports

Oddsmakers expect a close contest when the Rice Owls (2-1) visit the Charlotte 49ers (1-2) on Thursday, September 18, 2025 in a matchup between AAC foes at Jerry Richardson Stadium. Rice is favored by 2.5 points. The over/under is 42.5 for this game.

In their last action, the Owls won versus the Prairie View A&M Panthers, 38-17. The 49ers beat the Monmouth Hawks, 42-35, in their most recent contest.

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Rice vs. Charlotte Game Information & Odds

When: Thursday, September 18, 2025 at 7:30 p.m. ET
Location: Jerry Richardson Stadium in Charlotte, North Carolina
TV: ESPN
Live Box Score on FOX Sports

Rice vs Charlotte Betting Information updated as of September 18, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Rice	-2.5 (-108)	-132	+111	42.5	-110	-110

Rice vs. Charlotte Prediction

Pick ATS: Charlotte (+2.5)
Pick OU: Under (42.5)
Prediction: Charlotte 18, Rice 17

Predictions are made by the Data Skrive betting model.

Learn more about the Rice Owls vs. the Charlotte 49ers game on FOX Sports!

Rice vs. Charlotte Betting Insights

Per the spread and over/under, the implied score for the matchup is Owls 22, 49ers 20.
The Owls have a 56.9% chance to win this meeting based on the moneyline's implied probability. The 49ers have a 47.4% implied probability.
Rice has covered once in three matchups with a spread this season.
Charlotte has covered once in three matchups with a spread this year.

Rice vs. Charlotte: Head-to-Head

Over their last four meetings, Charlotte has tallied three wins against Rice.
The last four times the 49ers have squared off with the Owls, they have a 3-1 record against the spread. The scoring has gone over the point total on two occasions.
Rice has been outscored by 20 points in its last four tilts against Charlotte.

Rice vs. Charlotte: 2025 Stats Comparison

	Rice	Charlotte
Off. Points per Game (Rank)	20.3 (101)	18.7 (112)
Def. Points per Game (Rank)	21.3 (72)	29.7 (110)
Turnovers Allowed (Rank)	2 (27)	7 (125)
Turnovers Forced (Rank)	2 (95)	1 (118)

Rice 2025 Key Players

Name	Position	Stats
Chase Jenkins	QB	182 YDS (73%) / 1 TD / 1 INT 144 RUSH YDS / 2 RUSH TD / 48 RUSH YPG
Quinton Jackson	RB	213 YDS / 2 TD / 71 YPG / 4.6 YPC
Aaron Turner	WR	7 REC / 33 YDS / 0 TD / 11 YPG
Daelen Alexander	RB	149 YDS / 0 TD / 49.7 YPG / 4.7 YPC
Tony Anyanwu	DL	7 TKL / 0 TFL / 1 SACK
Michael Daley	DL	5 TKL / 2 TFL / 2 SACK
Andrew Awe	LB	11 TKL / 1 TFL / 0.5 SACK
Joseph Mutombo	DL	3 TKL / 1 TFL / 1.5 SACK

Charlotte 2025 Key Players

Name	Position	Stats
Conner Harrell	QB	664 YDS (67.5%) / 4 TD / 2 INT 45 RUSH YDS / 2 RUSH TD / 15 RUSH YPG
E. Jai Mason	WR	16 REC / 284 YDS / 3 TD / 94.7 YPG
Javen Nicholas	WR	17 REC / 177 YDS / 0 TD / 59 YPG
Rod Gainey Jr.	RB	94 YDS / 1 TD / 31.3 YPG / 4.1 YPC
Ja'Qurious Conley	DB	16 TKL / 0 TFL
Reid Williford	LB	11 TKL / 2 TFL / 2 SACK
Shay Taylor	LB	18 TKL / 1 TFL / 0.5 SACK
Curtis Simpson	DL	10 TKL / 1 TFL / 1.5 SACK