Pittsburgh vs. NC State Prediction, Odds, Picks - October 25, 2025

Updated Oct. 25, 2025 3:04 p.m. ET

FOX Sports

The Pittsburgh Panthers (5-2) are 5.5-point favorites when they host the NC State Wolfpack (4-3) in an ACC matchup on Saturday, October 25, 2025 at Acrisure Stadium. An over/under of 53.5 is set for the game.

The Panthers beat the Syracuse Orange, 30-13, in their last game. In their most recent contest, the Wolfpack lost versus the Notre Dame Fighting Irish, 36-7.

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Pittsburgh vs. NC State Game Information & Odds

When: Saturday, October 25, 2025 at 3:30 p.m. ET
Location: Acrisure Stadium in Pittsburgh, Pennsylvania
TV: ACC Network
Live Box Score on FOX Sports

Pittsburgh vs NC State Betting Information updated as of October 25, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Pittsburgh	-5.5 (-108)	-207	+171	53.5	-108	-112

Pittsburgh vs. NC State Prediction

Pick ATS: Pittsburgh (-5.5)
Pick OU: Over (53.5)
Prediction: Pittsburgh 33, NC State 23

Predictions are made by the Data Skrive betting model.

Learn more about the Pittsburgh Panthers vs. the NC State Wolfpack game on FOX Sports!

Pittsburgh vs. NC State Betting Insights

Based on the spread and over/under, the implied score for the matchup is Panthers 30, Wolfpack 24.
The Panthers have a 67.4% chance to claim victory in this game per the moneyline's implied probability. The Wolfpack have a 36.9% implied probability.
Pittsburgh has compiled a 5-2-0 record against the spread this season.
NC State has covered three times in seven chances against the spread this year.

Pittsburgh vs. NC State: 2025 Stats Comparison

	Pittsburgh	NC State
Off. Points per Game (Rank)	38.4 (14)	30 (56)
Def. Points per Game (Rank)	20.3 (39)	26.6 (82)
Turnovers Allowed (Rank)	11 (104)	10 (90)
Turnovers Forced (Rank)	11 (30)	5 (116)

Pittsburgh 2025 Key Players

Name	Position	Stats
Eli Holstein	QB	1,058 YDS (62.7%) / 11 TD / 5 INT 83 RUSH YDS / 1 RUSH TD / 16.6 RUSH YPG
Raphael Williams	WR	28 REC / 466 YDS / 4 TD / 66.6 YPG
Desmond Reid	RB	225 YDS / 1 TD / 45 YPG / 5.4 YPC 14 REC / 226 REC YDS / 2 REC TD / 56.5 REC YPG
Mason Heintschel	QB	823 YDS (68.4%) / 6 TD / 3 INT 115 RUSH YDS / 1 RUSH TD / 38.3 RUSH YPG
Kyle Louis	LB	40 TKL / 5 TFL / 2 SACK / 1 INT
Rasheem Biles	LB	51 TKL / 5 TFL / 2 SACK / 1 INT
Braylan Lovelace	LB	46 TKL / 3 TFL / 1 INT / 1 PD
Cruce Brookins	DB	33 TKL / 1 TFL / 1 INT / 1 PD

NC State 2025 Key Players

Name	Position	Stats
CJ Bailey	QB	1,846 YDS (72.1%) / 14 TD / 7 INT 64 RUSH YDS / 3 RUSH TD / 9.1 RUSH YPG
Daylan Smothers	RB	739 YDS / 5 TD / 105.6 YPG / 6.6 YPC 25 REC / 145 REC YDS / 1 REC TD / 20.7 REC YPG
Terrell Anderson	WR	24 REC / 445 YDS / 4 TD / 63.6 YPG
Jayden Scott	RB	211 YDS / 3 TD / 30.1 YPG / 4.8 YPC 8 REC / 70 REC YDS / 0 REC TD / 14 REC YPG
Caden Fordham	LB	67 TKL / 3 TFL / 2 SACK
Cian Slone	LB	31 TKL / 2 TFL / 1 SACK / 1 INT
Sean Brown	LB	43 TKL / 3 TFL
Ronnie Royal III	DB	32 TKL / 0 TFL / 1 INT / 1 PD