Pittsburgh vs. Boston College Prediction, Odds, Picks - October 4, 2025

Updated Oct. 4, 2025 9:04 a.m. ET

Data Skrive

The Pittsburgh Panthers (2-2) are 6.5-point favorites at home at Acrisure Stadium against the Boston College Eagles (1-3) on Saturday, October 4, 2025. Both teams have strong passing games, with the Panthers 19th in passing yards per game, and the Eagles fourth. The over/under is 56.5 for the contest.

The Panthers lost to the Louisville Cardinals, 34-27, in their last contest. Last time out, the Eagles fell to the California Golden Bears, with 28-24 being the final score.

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Pittsburgh vs. Boston College Game Information & Odds

When: Saturday, October 4, 2025 at 12 p.m. ET
Location: Acrisure Stadium in Pittsburgh, Pennsylvania
TV: ACC Network
Live Box Score on FOX Sports

Pittsburgh vs Boston College Betting Information updated as of October 4, 2025, 8:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Pittsburgh	-6.5 (-117)	-248	+198	56.5	-112	-108

Pittsburgh vs. Boston College Prediction

Pick ATS: Pittsburgh (-6.5)
Pick OU: Over (56.5)
Prediction: Pittsburgh 37, Boston College 23

Predictions are made by the Data Skrive betting model.

Learn more about the Pittsburgh Panthers vs. the Boston College Eagles game on FOX Sports!

Pittsburgh vs. Boston College Betting Insights

Per the spread and over/under, the implied score for the game is Panthers 32, Eagles 25.
The Panthers have a 71.3% chance to claim victory in this meeting based on the moneyline's implied probability. The Eagles hold a 33.6% implied probability.
Pittsburgh has covered twice in four matchups with a spread this season.
Boston College has a record of 2-2-0 against the spread this year.

Pittsburgh vs. Boston College: Head-to-Head

In their past two matchups, Boston College holds a split 1-1 record against Pittsburgh.
The Panthers and the Eagles have matched up evenly over their last two games, sporting a split 1-1 record against the spread. In those two games, the two squads have eclipsed the over on the point total on one occasion.
In their last two head-to-head matchups, Boston College has tallied 50 points against Pittsburgh, while giving up only 47 points.

Pittsburgh vs. Boston College: 2025 Stats Comparison

	Pittsburgh	Boston College
Off. Points per Game (Rank)	39.3 (35)	37.5 (46)
Def. Points per Game (Rank)	22.8 (47)	27.5 (72)
Turnovers Allowed (Rank)	8 (114)	6 (74)
Turnovers Forced (Rank)	4 (93)	3 (111)

Pittsburgh 2025 Key Players

Name	Position	Stats
Eli Holstein	QB	1,050 YDS (63.2%) / 11 TD / 5 INT 69 RUSH YDS / 1 RUSH TD / 17.3 RUSH YPG
Raphael Williams	WR	17 REC / 342 YDS / 4 TD / 85.5 YPG
Cataurus Hicks	WR	11 REC / 197 YDS / 3 TD / 49.3 YPG
Desmond Reid	RB	142 YDS / 1 TD / 47.3 YPG / 5.9 YPC 6 REC / 71 REC YDS / 0 REC TD / 23.7 REC YPG
Rasheem Biles	LB	40 TKL / 5 TFL / 1 SACK / 1 INT
Kyle Louis	LB	25 TKL / 4 TFL / 2 SACK / 1 INT
Braylan Lovelace	LB	29 TKL / 3 TFL / 1 INT / 1 PD
Blaine Spires	DL	12 TKL / 4 TFL / 2.5 SACK

Boston College 2025 Key Players

Name	Position	Stats
Turbo Richard	RB	329 YDS / 4 TD / 82.3 YPG / 5.7 YPC 16 REC / 168 REC YDS / 2 REC TD / 42 REC YPG
Dylan Lonergan	QB	1,188 YDS (69.4%) / 9 TD / 3 INT -11 RUSH YDS / 1 RUSH TD / -2.8 RUSH YPG
Reed Harris	WR	15 REC / 250 YDS / 2 TD / 62.5 YPG
Lewis Bond	WR	36 REC / 352 YDS / 0 TD / 88 YPG
Omar Thornton	DB	10 TKL / 3 TFL / 1 SACK / 1 INT
Daveon Crouch	LB	10 TKL / 1 TFL / 1 SACK / 1 INT
Owen McGowan	LB	9 TKL / 2 TFL / 1 SACK
Carter Davis	DB	9 TKL / 1 TFL / 1 SACK