Oregon vs. James Madison Prediction, Odds, Picks - December 20, 2025

Updated Dec. 20, 2025 3:04 p.m. ET

Data Skrive

The Oregon Ducks (11-1) host the James Madison Dukes (12-1) at Autzen Stadium in Eugene, Oregon in the first round of the College Football Playoff. Opening kick is at 7:30 p.m. ET, and Oregon is a 20.5 favorite. The over/under is set at 46.5.

The Ducks' most recent game was against the Washington Huskies, and they won by a score of 26-14. The Dukes' last game was versus the Troy Trojans, and they won by a score of 31-14.

Keep up with college football all season on FOX Sports.

Oregon vs. James Madison Game Information & Odds

When: Saturday, December 20, 2025 at 7:30 p.m. ET
Location: Autzen Stadium in Eugene, Oregon
TV: TNT
Live Box Score on FOX Sports

Oregon vs James Madison Betting Information updated as of December 20, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Oregon	-20.5 (-114)	-1852	+1000	46.5	-108	-117

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Oregon vs. James Madison Prediction

Pick ATS: James Madison (+20.5)
Pick OU: Over (46.5)
Prediction: Oregon 33, James Madison 19

Predictions are made by the Data Skrive betting model.

Learn more about the Oregon Ducks vs. the James Madison Dukes game on FOX Sports!

Oregon vs. James Madison Betting Insights

Per the spread and over/under, the implied score for the tilt is Ducks 34, Dukes 13.
The Ducks have a 94.9% chance to claim victory in this game based on the moneyline's implied probability. The Dukes hold a 9.1% implied probability.
Oregon is 7-5-0 ATS this season.
James Madison is 8-5-0 ATS this season.

Oregon vs. James Madison: 2025 Stats Comparison

	Oregon	James Madison
Off. Points per Game (Rank)	38.2 (11)	37.3 (8)
Def. Points per Game (Rank)	14.8 (7)	15.8 (10)
Turnovers Allowed (Rank)	9 (8)	16 (72)
Turnovers Forced (Rank)	17 (50)	15 (68)

Oregon 2025 Key Players

Name	Position	Stats
Dante Moore	QB	2,733 YDS (72.5%) / 24 TD / 6 INT 191 RUSH YDS / 1 RUSH TD / 15.9 RUSH YPG
Jordon Davison	RB	535 YDS / 13 TD / 44.6 YPG / 6.1 YPC
Noah Whittington	RB	774 YDS / 6 TD / 77.4 YPG / 6.9 YPC 16 REC / 76 REC YDS / 1 REC TD / 10.9 REC YPG
Kenyon Sadiq	TE	40 REC / 490 YDS / 8 TD / 44.5 YPG
Teitum Tuioti	LB	49 TKL / 8 TFL / 7 SACK
Bryce Boettcher	LB	72 TKL / 1 TFL / 1 SACK / 1 INT
Dillon Thieneman	DB	49 TKL / 1 TFL / 1 SACK / 2 INT
Aaron Flowers	DB	43 TKL / 1 TFL / 1 INT / 1 PD

James Madison 2025 Key Players

Name	Position	Stats
Alonza Barnett III	QB	2,533 YDS (59.9%) / 21 TD / 8 INT 544 RUSH YDS / 14 RUSH TD / 41.8 RUSH YPG
Wayne Knight	RB	1,263 YDS / 9 TD / 97.2 YPG / 6.6 YPC 37 REC / 379 REC YDS / 1 REC TD / 29.2 REC YPG
Landon Ellis	WR	33 REC / 541 YDS / 5 TD / 49.2 YPG
Jordan Fuller	RB	415 YDS / 5 TD / 51.9 YPG / 5.1 YPC
Sahir West	DL	27 TKL / 8 TFL / 6.5 SACK
Trent Hendrick	LB	44 TKL / 4 TFL / 3 SACK
Xavier Holmes	DL	16 TKL / 5 TFL / 6 SACK / 1 INT
Jacob Thomas	DB	34 TKL / 2 TFL / 2 SACK / 2 INT