Oregon vs. James Madison Prediction, Odds, Picks - December 20, 2025

Updated Dec. 18, 2025 3:06 a.m. ET

Data Skrive

To start this year's College Football Playoff, the Oregon Ducks (11-1) will host the James Madison Dukes (12-1) starting at 7:30 p.m. ET at Autzen Stadium in Eugene, Oregon. Oregon is favored by 21 points. The game has a 47.5-point over/under.

Facing the Washington Huskies in their last game, the Ducks won 26-14. Last time out, the Dukes defeated the Troy Trojans, with 31-14 being the final score.

Keep up with college football all season on FOX Sports.

Oregon vs. James Madison Game Information & Odds

When: Saturday, December 20, 2025 at 7:30 p.m. ET
Location: Autzen Stadium in Eugene, Oregon
TV: TNT
Live Box Score on FOX Sports

Oregon vs James Madison Betting Information updated as of December 18, 2025, 1:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Oregon	-21 (-109)	-2041	+1030	47.5	-110	-110

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Oregon vs. James Madison Prediction

Pick ATS: James Madison (+21)
Pick OU: Over (47.5)
Prediction: Oregon 33, James Madison 19

Predictions are made by the Data Skrive betting model.

Learn more about the Oregon Ducks vs. the James Madison Dukes game on FOX Sports!

Oregon vs. James Madison Betting Insights

Per the spread and over/under, the implied score for the tilt is Ducks 34, Dukes 13.
The Ducks have a 95.3% chance to collect the win in this contest based on the moneyline's implied probability. The Dukes hold an 8.8% implied probability.
Oregon has won seven games against the spread this season, while failing to cover five times.
James Madison is 8-5-0 ATS this year.

Oregon vs. James Madison: 2025 Stats Comparison

	Oregon	James Madison
Off. Points per Game (Rank)	38.2 (11)	37.3 (8)
Def. Points per Game (Rank)	14.8 (8)	15.8 (10)
Turnovers Allowed (Rank)	9 (8)	16 (74)
Turnovers Forced (Rank)	17 (50)	15 (67)

Oregon 2025 Key Players

Name	Position	Stats
Dante Moore	QB	2,733 YDS (72.5%) / 24 TD / 6 INT 191 RUSH YDS / 1 RUSH TD / 15.9 RUSH YPG
Jordon Davison	RB	535 YDS / 13 TD / 44.6 YPG / 6.1 YPC
Noah Whittington	RB	774 YDS / 6 TD / 77.4 YPG / 6.9 YPC 16 REC / 76 REC YDS / 1 REC TD / 10.9 REC YPG
Kenyon Sadiq	TE	40 REC / 490 YDS / 8 TD / 44.5 YPG
Teitum Tuioti	LB	49 TKL / 8 TFL / 7 SACK
Bryce Boettcher	LB	72 TKL / 1 TFL / 1 SACK / 1 INT
Dillon Thieneman	DB	49 TKL / 1 TFL / 1 SACK / 2 INT
Aaron Flowers	DB	43 TKL / 1 TFL / 1 INT / 1 PD

James Madison 2025 Key Players

Name	Position	Stats
Alonza Barnett III	QB	2,533 YDS (59.9%) / 21 TD / 8 INT 544 RUSH YDS / 14 RUSH TD / 41.8 RUSH YPG
Wayne Knight	RB	1,263 YDS / 9 TD / 97.2 YPG / 6.6 YPC 37 REC / 379 REC YDS / 1 REC TD / 29.2 REC YPG
Landon Ellis	WR	33 REC / 541 YDS / 5 TD / 49.2 YPG
Jordan Fuller	RB	415 YDS / 5 TD / 51.9 YPG / 5.1 YPC
Sahir West	DL	27 TKL / 8 TFL / 6.5 SACK
Trent Hendrick	LB	44 TKL / 4 TFL / 3 SACK
Xavier Holmes	DL	16 TKL / 5 TFL / 6 SACK / 1 INT
Jacob Thomas	DB	34 TKL / 2 TFL / 2 SACK / 2 INT