Ole Miss vs. Tulane Prediction, Odds, Picks - September 20, 2025

Updated Sep. 20, 2025 3:04 p.m. ET

FOX Sports

The Tulane Green Wave (3-0) will attempt to defy oddsmakers when they square off against the No. 13 Ole Miss Rebels (3-0) on Saturday, September 20, 2025 as a 12.5-point underdog. The total is 61.5 points for this game.

Against the Arkansas Razorbacks in their most recent contest, the Rebels won 41-35. Last time out, the Green Wave defeated the Duke Blue Devils, with 34-27 being the final score.

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Ole Miss vs. Tulane Game Information & Odds

When: Saturday, September 20, 2025 at 3:30 p.m. ET
Location: Vaught-Hemingway Stadium in Oxford, Mississippi
TV: ESPN
Live Box Score on FOX Sports

Ole Miss vs Tulane Betting Information updated as of September 20, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Ole Miss	-12.5 (-108)	-441	+336	61.5	-110	-110

Ole Miss vs. Tulane Prediction

Pick ATS: Ole Miss (-12.5)
Pick OU: Under (61.5)
Prediction: Ole Miss 38, Tulane 20

Predictions are made by the Data Skrive betting model.

Learn more about the Ole Miss Rebels vs. the Tulane Green Wave game on FOX Sports!

Ole Miss vs. Tulane Betting Insights

Based on the spread and over/under, the implied score for the game is Rebels 37, Green Wave 24.
The Rebels have an 81.5% chance to collect the win in this meeting based on the moneyline's implied probability. The Green Wave hold a 22.9% implied probability.
Ole Miss has a record of 2-1-0 against the spread this season.
Tulane has covered twice in three chances against the spread this season.

Ole Miss vs. Tulane: Head-to-Head

Ole Miss holds a 2-0 record against Tulane in their last two matchups.
The last two times the Rebels have squared off with the Green Wave, they have a 2-0 record against the spread. The scoring has gone over the point total on one occasion.
Over their last two head-to-head contests, Ole Miss has racked up 98 points, while Tulane has accumulated 41.

Ole Miss vs. Tulane: 2025 Stats Comparison

	Ole Miss	Tulane
Off. Points per Game (Rank)	44.7 (14)	30 (67)
Def. Points per Game (Rank)	21.7 (73)	20.3 (66)
Turnovers Allowed (Rank)	4 (78)	2 (27)
Turnovers Forced (Rank)	2 (96)	8 (1)

Ole Miss 2025 Key Players

Name	Position	Stats
Kewan Lacy	RB	290 YDS / 5 TD / 96.7 YPG / 4.8 YPC 5 REC / 44 REC YDS / 0 REC TD / 22 REC YPG
Harrison Wallace III	WR	15 REC / 339 YDS / 2 TD / 113 YPG
Trinidad Chambliss	QB	412 YDS (71.4%) / 2 TD / 0 INT 83 RUSH YDS / 2 RUSH TD / 27.7 RUSH YPG
Austin Simmons	QB	580 YDS (60.7%) / 4 TD / 4 INT 69 RUSH YDS / 1 RUSH TD / 23 RUSH YPG
Zxavian Harris	DL	17 TKL / 3 TFL / 2 SACK / 1 INT
T.J. Dudley	LB	22 TKL / 0 TFL
Wydett Williams Jr.	DB	12 TKL / 0 TFL
Jaden Yates	LB	17 TKL / 0 TFL

Tulane 2025 Key Players

Name	Position	Stats
Jake Retzlaff	QB	522 YDS (59%) / 2 TD / 0 INT 288 RUSH YDS / 6 RUSH TD / 96 RUSH YPG
Zuberi Mobley	RB	107 YDS / 2 TD / 35.7 YPG / 5.1 YPC
Omari Hayes	WR	13 REC / 143 YDS / 0 TD / 47.7 YPG
Javin Gordon	RB	122 YDS / 0 TD / 40.7 YPG / 4.5 YPC
Jack Tchienchou	DB	21 TKL / 1 TFL / 1 SACK
Dickson Agu	LB	25 TKL / 1 TFL
Javion White	DB	7 TKL / 1 TFL / 3 INT / 3 PD
Bailey Despanie	DB	15 TKL / 1 TFL