Ole Miss vs. Kentucky Prediction, Odds, Picks - September 6, 2025

The No. 20 Ole Miss Rebels (1-0) are 8.5-point favorites when they visit the Kentucky Wildcats (1-0) in conference play on Saturday, September 6, 2025 at Kroger Field. The over/under is set at 51 points for the game.

The Rebels won versus the Georgia State Panthers in their last game, 63-7. Last time around, the Wildcats defeated the Toledo Rockets, with 24-16 being the final score.

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Ole Miss vs. Kentucky Game Information & Odds

• When: Saturday, September 6, 2025 at 3:30 p.m. ET
• Location: Kroger Field in Lexington, Kentucky
• TV: ABC
• Live Box Score on FOX Sports

Ole Miss vs. Kentucky Prediction

• Pick ATS: Kentucky (+8.5)
  
• Pick OU: Over (51)
  
• Prediction: Ole Miss 31, Kentucky 24

Predictions are made by the Data Skrive betting model.

Learn more about the Ole Miss Rebels vs. the Kentucky Wildcats game on FOX Sports!

Ole Miss vs. Kentucky Betting Insights

• Based on the spread and over/under, the implied score for the tilt is Rebels 30, Wildcats 21.
• The Rebels have a 77.4% chance to claim victory in this contest based on the moneyline's implied probability. The Wildcats have a 27.0% implied probability.
• Ole Miss has covered in its only game with a spread this season.
• Kentucky has not won against the spread this season in one games with a spread.

Ole Miss vs. Kentucky: Head-to-Head

• The last two times Kentucky and Ole Miss have squared off, the two teams share a split 1-1 record.
• The Wildcats carry a 2-0 record ATS in those games, while the two teams have yet to go over the total.
• Kentucky has put up 39 points in its last two tilts versus Ole Miss, matching the Rebels' offensive output (39 points) in those games.

Ole Miss vs. Kentucky: 2025 Stats Comparison

Ole Miss 2025 Key Players

Kentucky 2025 Key Players

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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