Oklahoma vs. Michigan Prediction, Odds, Picks - September 6, 2025

Updated Sep. 6, 2025 3:04 p.m. ET

Data Skrive

Oddsmakers give the No. 18 Oklahoma Sooners (1-0) the advantage on Saturday, September 6, 2025 against the No. 15 Michigan Wolverines (1-0). Oklahoma is favored by 5.5 points. The contest has an over/under of 43.5 points.

Last time out, the Sooners defeated the Illinois State Redbirds, with 35-3 being the final score. In their last contest, the Wolverines won against the New Mexico Lobos, 34-17.

Keep up with college football all season on FOX Sports.

Oklahoma vs. Michigan Game Information & Odds

When: Saturday, September 6, 2025 at 7:30 p.m. ET
Location: Gaylord Family Oklahoma Memorial Stadium in Norman, Oklahoma
TV: ABC
Live Box Score on FOX Sports

Oklahoma vs Michigan Betting Information updated as of September 6, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Oklahoma	-5.5 (-109)	-204	+169	43.5	-114	-106

Oklahoma vs. Michigan Prediction

Pick ATS: Michigan (+5.5)
Pick OU: Under (43.5)
Prediction: Michigan 23, Oklahoma 19

Predictions are made by the Data Skrive betting model.

Learn more about the Oklahoma Sooners vs. the Michigan Wolverines game on FOX Sports!

Oklahoma vs. Michigan Betting Insights

Based on the spread and over/under, the implied score for the game is Sooners 24, Wolverines 19.
The Sooners have a 67.1% chance to claim victory in this contest based on the moneyline's implied probability. The Wolverines have a 37.2% implied probability.
Oklahoma is winless against the spread this season (0-1-0).
Michigan has compiled a 0-1-0 record against the spread this season.

Oklahoma vs. Michigan: 2025 Stats Comparison

	Oklahoma	Michigan
Off. Points per Game (Rank)	35 (52)	34 (55)
Def. Points per Game (Rank)	3 (11)	17 (66)
Turnovers Allowed (Rank)	2 (100)	1 (55)
Turnovers Forced (Rank)	0 (94)	3 (8)

Oklahoma 2025 Key Players

Name	Position	Stats
John Mateer	QB	392 YDS (81.1%) / 3 TD / 1 INT 24 RUSH YDS / 1 RUSH TD / 24 RUSH YPG
Keontez Lewis	WR	9 REC / 119 YDS / 2 TD / 119 YPG
Deion Burks	WR	7 REC / 88 YDS / 1 TD / 88 YPG
Tory Blaylock	RB	44 YDS / 1 TD / 44 YPG / 5.5 YPC 2 REC / 18 REC YDS / 0 REC TD / 18 REC YPG
Samuel Omosigho	LB	2 TKL / 1 TFL / 1 SACK
Taylor Wein	DL	1 TKL / 1 TFL / 1 SACK
Kendal Daniels	LB	3 TKL / 0 TFL
R Mason Thomas	DL	1 TKL / 0 TFL

Michigan 2025 Key Players

Name	Position	Stats
Justice Haynes	RB	159 YDS / 3 TD / 159 YPG / 9.9 YPC
Marlin Klein	TE	6 REC / 93 YDS / 1 TD / 93 YPG
Bryce Underwood	QB	251 YDS (67.7%) / 1 TD / 0 INT
Channing Goodwin	WR	2 REC / 49 YDS / 0 TD / 49 YPG
Cole Sullivan	LB	1 TKL / 1 TFL / 1 SACK / 1 INT
Troy Bowles	LB	1 TKL / 1 TFL / 1 SACK
Dominic Nichols	DL	1 TKL / 1 TFL / 1 SACK
Brandyn Hillman	DB	0 TKL / 0 TFL / 1 INT / 1 PD