Oklahoma vs. LSU Prediction, Odds, Picks - November 29, 2025

Updated Nov. 29, 2025 3:04 p.m. ET

Data Skrive

The No. 8 Oklahoma Sooners (9-2) are double-digit, 10.5-point favorites at home at Gaylord Family Oklahoma Memorial Stadium against the LSU Tigers (7-4) on Saturday, November 29, 2025. Both teams have tough defenses, with the Sooners sixth in points per game allowed, and the Tigers 16th. The contest has a point total set at 36.5.

In their most recent game, the Sooners won versus the Missouri Tigers, 17-6. The Tigers beat the Western Kentucky Hilltoppers, 13-10, in their last game.

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Oklahoma vs. LSU Game Information & Odds

When: Saturday, November 29, 2025 at 3:30 p.m. ET
Location: Gaylord Family Oklahoma Memorial Stadium in Norman, Oklahoma
TV: ABC
Live Box Score on FOX Sports

Oklahoma vs LSU Betting Information updated as of November 29, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Oklahoma	-10.5 (-115)	-485	+372	36.5	-108	-121

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Oklahoma vs. LSU Prediction

Pick ATS: Oklahoma (-10.5)
Pick OU: Over (36.5)
Prediction: Oklahoma 28, LSU 13

Predictions are made by the Data Skrive betting model.

Learn more about the Oklahoma Sooners vs. the LSU Tigers game on FOX Sports!

Oklahoma vs. LSU Betting Insights

Per the spread and over/under, the implied score for the game is Sooners 24, Tigers 13.
The Sooners have an 82.9% chance to claim victory in this game based on the moneyline's implied probability. The Tigers hold a 21.2% implied probability.
Oklahoma has put together a 7-4-0 ATS record so far this year.
LSU has put together a 3-8-0 record against the spread this season.

Oklahoma vs. LSU: 2025 Stats Comparison

	Oklahoma	LSU
Off. Points per Game (Rank)	27.3 (72)	22.6 (108)
Def. Points per Game (Rank)	14 (6)	18.5 (16)
Turnovers Allowed (Rank)	12 (38)	12 (38)
Turnovers Forced (Rank)	12 (89)	18 (31)

Oklahoma 2025 Key Players

Name	Position	Stats
John Mateer	QB	2,260 YDS (62.3%) / 10 TD / 7 INT 389 RUSH YDS / 7 RUSH TD / 38.9 RUSH YPG
Isaiah Sategna	WR	56 REC / 827 YDS / 6 TD / 75.2 YPG
Xavier Robinson	RB	408 YDS / 4 TD / 51 YPG / 5.5 YPC 14 REC / 89 REC YDS / 1 REC TD / 11.1 REC YPG
Tory Blaylock	RB	404 YDS / 4 TD / 40.4 YPG / 4.1 YPC
Taylor Wein	DL	29 TKL / 10 TFL / 6 SACK / 1 INT
R Mason Thomas	DL	21 TKL / 5 TFL / 6.5 SACK
Kip Lewis	LB	51 TKL / 6 TFL / 3 SACK
Owen Heinecke	LB	42 TKL / 3 TFL / 2 SACK

LSU 2025 Key Players

Name	Position	Stats
Garrett Nussmeier	QB	1,925 YDS (67.4%) / 12 TD / 5 INT -57 RUSH YDS / 1 RUSH TD / -6.3 RUSH YPG
Caden Durham	RB	463 YDS / 3 TD / 46.3 YPG / 4.6 YPC 15 REC / 90 REC YDS / 0 REC TD / 11.3 REC YPG
Zavion Thomas	WR	37 REC / 443 YDS / 3 TD / 40.3 YPG
Trey'Dez Green	TE	28 REC / 323 YDS / 5 TD / 35.9 YPG
Harold Perkins	LB	40 TKL / 4 TFL / 4 SACK / 2 INT
West Weeks	LB	60 TKL / 6 TFL / 2.5 SACK
Adari Haulcy	DB	58 TKL / 0 TFL / 2 INT / 2 PD
Tamarcus Cooley	DB	44 TKL / 0 TFL / 2 INT / 2 PD