Ohio State vs. Penn State Prediction, Odds, Picks - November 1, 2025

Updated Nov. 1, 2025 9:04 a.m. ET

Data Skrive

The No. 1 Ohio State Buckeyes (7-0), who have college football's third-ranked pass defense, square off against the Penn State Nittany Lions (3-4) and their fifth-ranked passing defense on Saturday, November 1, 2025. The Buckeyes are heavy, 18.5-point favorites. The point total for the game is set at 44.5.

Last time around, the Buckeyes defeated the Wisconsin Badgers, with 34-0 being the final score. The Nittany Lions lost against the Iowa Hawkeyes in their most recent game, 25-24.

Keep up with college football all season on FOX Sports.

Ohio State vs. Penn State Game Information & Odds

When: Saturday, November 1, 2025 at 12 p.m. ET
Location: Ohio Stadium in Columbus, Ohio
TV: FOX
Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Ohio State vs Penn State Betting Information updated as of November 1, 2025, 8:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Ohio State	-18.5 (-109)	-1235	+760	44.5	-109	-111

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Ohio State vs. Penn State Prediction

Pick ATS: Ohio State (-18.5)
Pick OU: Over (44.5)
Prediction: Ohio State 38, Penn State 8

Predictions are made by the Data Skrive betting model.

Learn more about the Ohio State Buckeyes vs. the Penn State Nittany Lions game on FOX Sports!

Ohio State vs. Penn State Betting Insights

Per the spread and over/under, the implied score for the matchup is Buckeyes 32, Nittany Lions 13.
The Buckeyes have a 92.5% chance to claim victory in this game per the moneyline's implied probability. The Nittany Lions have an 11.6% implied probability.
Ohio State has compiled a 6-1-0 record against the spread this season.
Penn State has a record of just 1-6-0 against the spread this season.

Ohio State vs. Penn State: Head-to-Head

Over their last four meetings, Ohio State has tallied four wins against Penn State.
In their last four head-to-head meetings, each team has covered two times with those games outscoring the point total on one occasion.
Penn State has been outpaced by 37 points in its last four tilts against Ohio State.

Ohio State vs. Penn State: 2025 Stats Comparison

	Ohio State	Penn State
Off. Points per Game (Rank)	36.4 (40)	34 (53)
Def. Points per Game (Rank)	5.9 (1)	19.4 (19)
Turnovers Allowed (Rank)	4 (3)	7 (23)
Turnovers Forced (Rank)	8 (85)	9 (73)

Ohio State 2025 Key Players

Name	Position	Stats
Julian Sayin	QB	1,872 YDS (80%) / 19 TD / 3 INT
Jeremiah Smith	WR	49 REC / 602 YDS / 7 TD / 86 YPG
Carnell Tate	WR	34 REC / 587 YDS / 6 TD / 83.9 YPG
Bo Jackson	RB	433 YDS / 2 TD / 72.2 YPG / 6.4 YPC 11 REC / 114 REC YDS / 1 REC TD / 22.8 REC YPG
Caden Curry	DL	33 TKL / 10 TFL / 7 SACK
Arvell Reese	LB	42 TKL / 6 TFL / 5.5 SACK
Kayden McDonald	DL	29 TKL / 5 TFL / 3 SACK
Sonny Styles	LB	41 TKL / 2 TFL / 1 INT / 1 PD

Penn State 2025 Key Players

Name	Position	Stats
Kaytron Allen	RB	612 YDS / 9 TD / 87.4 YPG / 6.2 YPC
Drew Allar	QB	1,100 YDS (64.8%) / 8 TD / 3 INT 172 RUSH YDS / 1 RUSH TD / 28.7 RUSH YPG
Nicholas Singleton	RB	274 YDS / 6 TD / 39.1 YPG / 3.6 YPC 13 REC / 95 REC YDS / 0 REC TD / 13.6 REC YPG
Devonte Ross	WR	18 REC / 255 YDS / 3 TD / 36.4 YPG
Amare Campbell	LB	50 TKL / 5 TFL / 2 SACK
Zakee Wheatley	DB	49 TKL / 1 TFL / 1 INT / 1 PD
Dani Dennis-Sutton	DL	24 TKL / 4 TFL / 2 SACK
Dominic DeLuca	LB	36 TKL / 2 TFL / 1 SACK