Ohio State vs. Ohio Prediction, Odds, Picks - September 13, 2025

The No. 1 Ohio State Buckeyes (2-0) are overwhelming 28.5-point favorites on Saturday, September 13, 2025 against the Ohio Bobcats (1-1). A 49.5-point over/under is set for the contest.

Against the Grambling State Tigers in their most recent game, the Buckeyes won 70-0. The Bobcats' most recent contest was against the West Virginia Mountaineers, and they won by a score of 17-10.

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Ohio State vs. Ohio Game Information & Odds

• When: Saturday, September 13, 2025 at 7 p.m. ET
• Location: Ohio Stadium in Columbus, Ohio
• TV: Peacock
• Live Box Score on FOX Sports

Ohio State vs. Ohio Prediction

• Pick ATS: Ohio (+28.5)
  
• Pick OU: Under (49.5)
  
• Prediction: Ohio State 23, Ohio 11

Predictions are made by the Data Skrive betting model.

Learn more about the Ohio State Buckeyes vs. the Ohio Bobcats game on FOX Sports!

Ohio State vs. Ohio Betting Insights

• Based on the spread and over/under, the implied score for the game is Buckeyes 39, Bobcats 10.
• The Buckeyes have a 98.6% chance to win this contest per the moneyline's implied probability. The Bobcats hold a 5.0% implied probability.
• Ohio State has covered twice in two games with a spread this season.
• Ohio has won all two of its games against the spread this year.

Ohio State vs. Ohio: 2025 Stats Comparison

Ohio State 2025 Key Players

Ohio 2025 Key Players

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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