Ohio State vs. Ohio Prediction, Odds, Picks - September 13, 2025

Updated Sep. 13, 2025 3:04 p.m. ET

Data Skrive

The No. 1 Ohio State Buckeyes (2-0) are overwhelming 28.5-point favorites on Saturday, September 13, 2025 against the Ohio Bobcats (1-1). A 49.5-point over/under is set for the contest.

Against the Grambling State Tigers in their most recent game, the Buckeyes won 70-0. The Bobcats' most recent contest was against the West Virginia Mountaineers, and they won by a score of 17-10.

Keep up with college football all season on FOX Sports.

Ohio State vs. Ohio Game Information & Odds

When: Saturday, September 13, 2025 at 7 p.m. ET
Location: Ohio Stadium in Columbus, Ohio
TV: Peacock
Live Box Score on FOX Sports

Ohio State vs Ohio Betting Information updated as of September 13, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Ohio State	-28.5 (-111)	-7143	+1920	49.5	-111	-109

Ohio State vs. Ohio Prediction

Pick ATS: Ohio (+28.5)
Pick OU: Under (49.5)
Prediction: Ohio State 23, Ohio 11

Predictions are made by the Data Skrive betting model.

Learn more about the Ohio State Buckeyes vs. the Ohio Bobcats game on FOX Sports!

Ohio State vs. Ohio Betting Insights

Based on the spread and over/under, the implied score for the game is Buckeyes 39, Bobcats 10.
The Buckeyes have a 98.6% chance to win this contest per the moneyline's implied probability. The Bobcats hold a 5.0% implied probability.
Ohio State has covered twice in two games with a spread this season.
Ohio has won all two of its games against the spread this year.

Ohio State vs. Ohio: 2025 Stats Comparison

	Ohio State	Ohio
Off. Points per Game (Rank)	42 (37)	24 (92)
Def. Points per Game (Rank)	3.5 (2)	22 (75)
Turnovers Allowed (Rank)	1 (22)	3 (83)
Turnovers Forced (Rank)	4 (19)	1 (96)

Ohio State 2025 Key Players

Name	Position	Stats
Julian Sayin	QB	432 YDS (79.5%) / 5 TD / 1 INT
Jeremiah Smith	WR	11 REC / 162 YDS / 2 TD / 81 YPG
CJ Donaldson	RB	112 YDS / 2 TD / 56 YPG / 4.7 YPC
Carnell Tate	WR	7 REC / 118 YDS / 2 TD / 59 YPG
Arvell Reese	LB	13 TKL / 1 TFL / 1 SACK
Caden Curry	DL	9 TKL / 2 TFL / 1 SACK
Kayden McDonald	DL	12 TKL / 0 TFL
Caleb Downs	DB	7 TKL / 1 TFL / 1 INT / 1 PD

Ohio 2025 Key Players

Name	Position	Stats
Parker Navarro	QB	486 YDS (69.4%) / 4 TD / 3 INT 180 RUSH YDS / 1 RUSH TD / 90 RUSH YPG
Chase Hendricks	WR	17 REC / 236 YDS / 1 TD / 118 YPG
Sieh Bangura	RB	152 YDS / 1 TD / 76 YPG / 4.2 YPC 4 REC / 21 REC YDS / 0 REC TD / 10.5 REC YPG
Jake Bruno	TE	2 REC / 27 YDS / 2 TD / 13.5 YPG
Michael Molnar	LB	14 TKL / 1 TFL / 1.5 SACK
DJ Walker	DB	13 TKL / 1 TFL
Adonis Williams Jr.	DB	14 TKL / 1 TFL
Anas Luqman	DL	7 TKL / 2 TFL / 1 SACK