Missouri vs. South Carolina Prediction, Odds, Picks - September 20, 2025

Updated Sep. 20, 2025 3:04 p.m. ET

FOX Sports

The No. 23 Missouri Tigers (3-0) are 10-point favorites when they host the South Carolina Gamecocks (2-1) in an SEC matchup on Saturday, September 20, 2025 at Memorial Stadium/Faurot Field. A total of 48.5 points has been set for this matchup.

The Tigers' last game was against the Louisiana Ragin' Cajuns, and they won by a score of 52-10. The Gamecocks lost against the Vanderbilt Commodores in their last game, 31-7.

Keep up with college football all season on FOX Sports.

Missouri vs. South Carolina Game Information & Odds

When: Saturday, September 20, 2025 at 7 p.m. ET
Location: Memorial Stadium/Faurot Field in Columbia, Missouri
TV: ESPN
Live Box Score on FOX Sports

Missouri vs South Carolina Betting Information updated as of September 20, 2025, 1:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Missouri	-10 (-110)	-351	+275	48.5	-110	-110

Missouri vs. South Carolina Prediction

Pick ATS: South Carolina (+10)
Pick OU: Over (48.5)
Prediction: Missouri 30, South Carolina 22

Predictions are made by the Data Skrive betting model.

Learn more about the Missouri Tigers vs. the South Carolina Gamecocks game on FOX Sports!

Missouri vs. South Carolina Betting Insights

Per the spread and over/under, the implied score for the game is Tigers 29, Gamecocks 19.
The Tigers have a 77.8% chance to claim victory in this game per the moneyline's implied probability. The Gamecocks have a 26.7% implied probability.
Missouri has won three games against the spread this season, while failing to cover zero times.
South Carolina has a record of 1-2-0 against the spread this season.

Missouri vs. South Carolina: Head-to-Head

Missouri owns a 3-1 record against South Carolina in their last four matchups.
The last four times the Tigers have squared off with the Gamecocks, they have put up a 4-0 record against the spread. The scoring has gone over the total on two occasions.
South Carolina has been outscored by 34 points in its last four tilts versus Missouri.

Missouri vs. South Carolina: 2025 Stats Comparison

	Missouri	South Carolina
Off. Points per Game (Rank)	51.7 (7)	23 (94)
Def. Points per Game (Rank)	15.7 (41)	17.3 (47)
Turnovers Allowed (Rank)	2 (27)	4 (78)
Turnovers Forced (Rank)	3 (69)	4 (47)

Missouri 2025 Key Players

Name	Position	Stats
Beau Pribula	QB	791 YDS (76.4%) / 7 TD / 1 INT 76 RUSH YDS / 3 RUSH TD / 25.3 RUSH YPG
Ahmad Hardy	RB	462 YDS / 5 TD / 154 YPG / 8.1 YPC
Jamal Roberts	RB	222 YDS / 1 TD / 74 YPG / 7.7 YPC 4 REC / 56 REC YDS / 1 REC TD / 18.7 REC YPG
Kevin Coleman Jr.	WR	24 REC / 258 YDS / 1 TD / 86 YPG
Damon Wilson Jr.	DL	6 TKL / 3 TFL / 3 SACK
Zion Young	DL	8 TKL / 2 TFL / 1 SACK
Josiah Trotter	LB	14 TKL / 4 TFL
Daylan Carnell	DB	7 TKL / 1 TFL / 1 INT / 1 PD

South Carolina 2025 Key Players

Name	Position	Stats
LaNorris Sellers	QB	431 YDS (64.4%) / 2 TD / 1 INT 45 RUSH YDS / 1 RUSH TD / 15 RUSH YPG
Nyck Harbor	WR	7 REC / 165 YDS / 1 TD / 55 YPG
Rahsul Faison	RB	135 YDS / 1 TD / 45 YPG / 5 YPC
Vicari Swain	DB	135 YDS / 1 TD / 45 YPG / 5 YPC
Dylan Stewart	DL	14 TKL / 5 TFL / 3 SACK
Bryan Thomas Jr.	DL	9 TKL / 2 TFL / 1 SACK
Fred Johnson	LB	14 TKL / 0 TFL / 1 INT / 1 PD
DQ Smith	DB	15 TKL / 0 TFL