Michigan vs. Nebraska Prediction, Odds, Picks - September 20, 2025

Updated Sep. 20, 2025 3:04 p.m. ET

FOX Sports

Big Ten rivals square off when the No. 21 Michigan Wolverines (2-1) visit the Nebraska Cornhuskers (3-0) on Saturday, September 20, 2025 at Memorial Stadium (Lincoln, NE). Michigan is favored by 1 point. A total of 47.5 points has been set for this matchup.

The Wolverines won versus the Central Michigan Chippewas in their last game, 63-3. The Cornhuskers' last game was versus the Houston Christian Huskies, and they won by a score of 59-7.

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Michigan vs. Nebraska Game Information & Odds

When: Saturday, September 20, 2025 at 3:30 p.m. ET
Location: Memorial Stadium (Lincoln, NE) in Lincoln, Nebraska
TV: CBS
Live Box Score on FOX Sports

Michigan vs Nebraska Betting Information updated as of September 20, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Michigan	-1 (-103)	-114	-106	47.5	-111	-109

Michigan vs. Nebraska Prediction

Pick ATS: Michigan (-1)
Pick OU: Over (47.5)
Prediction: Michigan 28, Nebraska 24

Predictions are made by the Data Skrive betting model.

Learn more about the Michigan Wolverines vs. the Nebraska Cornhuskers game on FOX Sports!

Michigan vs. Nebraska Betting Insights

Per the spread and over/under, the implied score for the game is Wolverines 24, Cornhuskers 23.
The Wolverines have a 53.3% chance to claim victory in this game per the moneyline's implied probability. The Cornhuskers have a 51.5% implied probability.
Michigan has covered once in three games with a spread this season.
Nebraska has a record of 2-1-0 against the spread this year.

Michigan vs. Nebraska: Head-to-Head

In their past three head-to-head bouts, Michigan has won against Nebraska three times.
The Wolverines have a 3-0 record ATS in those games, while the two teams have gone over the total on two occasions.
Over their last three head-to-head contests, Michigan has put up 111 points, while Nebraska has posted 39.

Michigan vs. Nebraska: 2025 Stats Comparison

	Michigan	Nebraska
Off. Points per Game (Rank)	36.7 (41)	49 (8)
Def. Points per Game (Rank)	14.7 (37)	8 (9)
Turnovers Allowed (Rank)	2 (27)	1 (10)
Turnovers Forced (Rank)	7 (6)	5 (26)

Michigan 2025 Key Players

Name	Position	Stats
Justice Haynes	RB	388 YDS / 5 TD / 129.3 YPG / 7.9 YPC
Bryce Underwood	QB	628 YDS (57.5%) / 2 TD / 1 INT 108 RUSH YDS / 2 RUSH TD / 36 RUSH YPG
Jordan Marshall	RB	109 YDS / 2 TD / 36.3 YPG / 3.6 YPC
Semaj Morgan	WR	9 REC / 121 YDS / 1 TD / 40.3 YPG
Cole Sullivan	LB	6 TKL / 2 TFL / 2 SACK / 1 INT
Jaishawn Barham	LB	6 TKL / 2 TFL / 2 SACK
Troy Bowles	LB	2 TKL / 1 TFL / 1 SACK
Dominic Nichols	DL	3 TKL / 1 TFL / 1.5 SACK

Nebraska 2025 Key Players

Name	Position	Stats
Dylan Raiola	QB	831 YDS (76.6%) / 8 TD / 0 INT
Emmett Johnson	RB	326 YDS / 4 TD / 108.7 YPG / 6.3 YPC 11 REC / 41 REC YDS / 1 REC TD / 13.7 REC YPG
Dane Key	WR	13 REC / 190 YDS / 3 TD / 63.3 YPG
TJ Lateef	QB	254 YDS (91.7%) / 1 TD / 0 INT 32 RUSH YDS / 2 RUSH TD / 16 RUSH YPG
Williams Nwaneri	DL	6 TKL / 0 TFL
Riley Van Poppel	DL	2 TKL / 0 TFL / 1 SACK
Dasan McCullough	LB	5 TKL / 1 TFL / 1 SACK
Marques Watson-Trent	LB	3 TKL / 1 TFL / 1 SACK