Louisville vs. Virginia Tech Prediction, Odds, Picks - November 1, 2025

Updated Nov. 1, 2025 3:04 p.m. ET

Data Skrive

ACC opponents square off when the No. 16 Louisville Cardinals (6-1) visit the Virginia Tech Hokies (3-5) on Saturday, November 1, 2025 at Lane Stadium. Louisville is favored by 10 points. The total for this matchup has been set at 52.5 points.

The Cardinals' last game was against the Boston College Eagles, and they won by a score of 38-24. The Hokies beat the California Golden Bears, 42-34, in their most recent contest.

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Louisville vs. Virginia Tech Game Information & Odds

When: Saturday, November 1, 2025 at 3 p.m. ET
Location: Lane Stadium in Blacksburg, Virginia
TV: The CW
Live Box Score on FOX Sports

Louisville vs Virginia Tech Betting Information updated as of November 1, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Louisville	-10 (-115)	-386	+303	52.5	-110	-110

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Louisville vs. Virginia Tech Prediction

Pick ATS: Louisville (-10)
Pick OU: Over (52.5)
Prediction: Louisville 37, Virginia Tech 19

Predictions are made by the Data Skrive betting model.

Learn more about the Louisville Cardinals vs. the Virginia Tech Hokies game on FOX Sports!

Louisville vs. Virginia Tech Betting Insights

Based on the spread and over/under, the implied score for the tilt is Cardinals 31, Hokies 21.
The Cardinals have a 79.4% chance to win this meeting based on the moneyline's implied probability. The Hokies have a 24.8% implied probability.
Louisville has a record of 2-5-0 against the spread this season.
Virginia Tech has a record of just 2-6-0 against the spread this year.

Louisville vs. Virginia Tech: 2025 Stats Comparison

	Louisville	Virginia Tech
Off. Points per Game (Rank)	34.6 (50)	25.4 (85)
Def. Points per Game (Rank)	21.4 (31)	29.9 (105)
Turnovers Allowed (Rank)	12 (100)	10 (68)
Turnovers Forced (Rank)	16 (7)	5 (123)

Louisville 2025 Key Players

Name	Position	Stats
Miller Moss	QB	1,793 YDS (65%) / 10 TD / 5 INT -77 RUSH YDS / 6 RUSH TD / -11 RUSH YPG
Chris Bell	WR	48 REC / 687 YDS / 6 TD / 98.1 YPG
Isaac Brown	RB	652 YDS / 4 TD / 93.1 YPG / 8.7 YPC 11 REC / 42 REC YDS / 0 REC TD / 10.5 REC YPG
Keyjuan Brown	RB	227 YDS / 4 TD / 37.8 YPG / 5.7 YPC 7 REC / 97 REC YDS / 0 REC TD / 19.4 REC YPG
Antonio Watts	LB	27 TKL / 4 TFL / 2.5 SACK / 3 INT
TJ Quinn	LB	47 TKL / 2 TFL / 1 SACK / 2 INT
Clev Lubin	DL	31 TKL / 2 TFL / 3.5 SACK
D'Angelo Hutchinson	DB	47 TKL / 2 TFL / 1 INT / 1 PD

Virginia Tech 2025 Key Players

Name	Position	Stats
Kyron Drones	QB	1,516 YDS (59.7%) / 14 TD / 6 INT 414 RUSH YDS / 7 RUSH TD / 51.8 RUSH YPG
Marcellous Hawkins	RB	531 YDS / 1 TD / 66.4 YPG / 6.2 YPC 9 REC / 60 REC YDS / 1 REC TD / 8.6 REC YPG
Ayden Greene	WR	23 REC / 365 YDS / 2 TD / 45.6 YPG
Terion Stewart	RB	373 YDS / 0 TD / 62.2 YPG / 6.8 YPC
Kemari Copeland	DL	30 TKL / 4 TFL / 4 SACK / 1 INT
Ben Bell	DL	27 TKL / 2 TFL / 1.5 SACK
Kaleb Spencer	LB	32 TKL / 3 TFL / 0.5 SACK
Jaden Keller	LB	28 TKL / 1 TFL / 0.5 SACK