Louisiana vs. Eastern Michigan Prediction, Odds, Picks - September 20, 2025

Updated Sep. 20, 2025 3:04 p.m. ET

Data Skrive

The Louisiana Ragin' Cajuns (1-2) are favored by only 2.5 points against the Eastern Michigan Eagles (0-3) on Saturday, September 20, 2025. The over/under is set at 50.5.

Against the Missouri Tigers in their most recent contest, the Ragin' Cajuns lost 52-10. Last time around, the Eagles fell to the Kentucky Wildcats, with 48-23 being the final score.

Keep up with college football all season on FOX Sports.

Louisiana vs. Eastern Michigan Game Information & Odds

When: Saturday, September 20, 2025 at 3:30 p.m. ET
Location: Rynearson Stadium in Ypsilanti, Michigan
TV: ESPN+
Live Box Score on FOX Sports

Louisiana vs Eastern Michigan Betting Information updated as of September 20, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Louisiana	-2.5 (-109)	-134	+112	50.5	-112	-108

Louisiana vs. Eastern Michigan Prediction

Pick ATS: Eastern Michigan (+2.5)
Pick OU: Over (50.5)
Prediction: Eastern Michigan 31, Louisiana 28

Predictions are made by the Data Skrive betting model.

Learn more about the Louisiana Ragin' Cajuns vs. the Eastern Michigan Eagles game on FOX Sports!

Louisiana vs. Eastern Michigan Betting Insights

Per the spread and over/under, the implied score for the tilt is Ragin' Cajuns 26, Eagles 24.
The Ragin' Cajuns have a 57.3% chance to collect the win in this contest per the moneyline's implied probability. The Eagles have a 47.2% implied probability.
Louisiana is winless against the spread this season (0-2-0).
Eastern Michigan has covered once in three matchups with a spread this year.

Louisiana vs. Eastern Michigan: 2025 Stats Comparison

	Louisiana	Eastern Michigan
Off. Points per Game (Rank)	18.7 (113)	24.3 (88)
Def. Points per Game (Rank)	25.3 (91)	42.7 (135)
Turnovers Allowed (Rank)	2 (27)	1 (10)
Turnovers Forced (Rank)	3 (69)	0 (130)

Louisiana 2025 Key Players

Name	Position	Stats
Elijah Davis	RB	191 YDS / 2 TD / 63.7 YPG / 5.3 YPC
Zylan Perry	RB	226 YDS / 1 TD / 75.3 YPG / 7.5 YPC
Steven Blanco	RB	100 YDS / 1 TD / 50 YPG / 7.7 YPC
Walker Howard	QB	88 YDS (45.5%) / 0 TD / 1 INT 47 RUSH YDS / 1 RUSH TD / 47 RUSH YPG
Jaden Dugger	LB	21 TKL / 2 TFL / 1 SACK
Terrence Williams	LB	17 TKL / 2 TFL / 1 SACK
Jalen Clark	DB	11 TKL / 1 TFL / 1 INT / 1 PD
Trae Tomlinson	DB	8 TKL / 1 TFL / 1 SACK

Eastern Michigan 2025 Key Players

Name	Position	Stats
Noah Kim	QB	767 YDS (62.9%) / 4 TD / 1 INT 43 RUSH YDS / 1 RUSH TD / 14.3 RUSH YPG
Dontae McMillan	RB	219 YDS / 1 TD / 73 YPG / 7.3 YPC 7 REC / 90 REC YDS / 1 REC TD / 30 REC YPG
Terry Lockett Jr.	WR	16 REC / 230 YDS / 1 TD / 76.7 YPG
Tavierre Dunlap	RB	74 YDS / 1 TD / 24.7 YPG / 2.8 YPC 2 REC / 36 REC YDS / 0 REC TD / 18 REC YPG
Bryce Llewellyn	DB	18 TKL / 1 TFL
Marco Patierno	LB	18 TKL / 0 TFL
Barry Manning	DB	12 TKL / 1 TFL
Messiah Blair	DL	6 TKL / 0 TFL / 1 SACK