Iowa vs. Penn State Prediction, Odds, Picks - October 18, 2025

Updated Oct. 18, 2025 3:04 p.m. ET

Data Skrive

A pair of the nation's best passing defenses meet when the Iowa Hawkeyes (4-2) bring college football's 21st-ranked pass defense into a matchup with the Penn State Nittany Lions (3-3), who have the No. 13 passing defense, on Saturday, October 18, 2025. The Hawkeyes are 3-point favorites. An over/under of 41.5 is set in the contest.

The Hawkeyes beat the Wisconsin Badgers, 37-0, in their last game. The Nittany Lions' last game was versus the Northwestern Wildcats, and they lost by a score of 22-21.

Keep up with college football all season on FOX Sports.

Iowa vs. Penn State Game Information & Odds

When: Saturday, October 18, 2025 at 7 p.m. ET
Location: Kinnick Stadium in Iowa City, Iowa
TV: Peacock
Live Box Score on FOX Sports

Iowa vs Penn State Betting Information updated as of October 18, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Iowa	-3 (-112)	-159	+135	41.5	-105	-115

Iowa vs. Penn State Prediction

Pick ATS: Iowa (-3)
Pick OU: Over (41.5)
Prediction: Iowa 34, Penn State 15

Predictions are made by the Data Skrive betting model.

Learn more about the Iowa Hawkeyes vs. the Penn State Nittany Lions game on FOX Sports!

Iowa vs. Penn State Betting Insights

Per the spread and over/under, the implied score for the game is Hawkeyes 22, Nittany Lions 19.
The Hawkeyes have a 61.4% chance to win this meeting per the moneyline's implied probability. The Nittany Lions hold a 42.6% implied probability.
Iowa has compiled a 4-1-1 ATS record so far this year.
Penn State has compiled a 0-6-0 record against the spread this year.

Iowa vs. Penn State: Head-to-Head

Iowa and Penn State have been matched up evenly over their last two games, sharing the same 1-1 record.
The Hawkeyes and the Nittany Lions have been an even matchup over their last two contests, sporting an even 1-1 record against the spread. In those two games, the two squads have gone over the total on one occasion.
In their last two head-to-head matchups, Penn State has tallied 51 points against Iowa, while surrendering only 23 points.

Iowa vs. Penn State: 2025 Stats Comparison

	Iowa	Penn State
Off. Points per Game (Rank)	30.7 (61)	35.7 (35)
Def. Points per Game (Rank)	13 (8)	18.5 (25)
Turnovers Allowed (Rank)	5 (19)	5 (19)
Turnovers Forced (Rank)	6 (88)	8 (55)

Iowa 2025 Key Players

Name	Position	Stats
Mark Gronowski	QB	743 YDS (65.4%) / 3 TD / 3 INT 159 RUSH YDS / 8 RUSH TD / 26.5 RUSH YPG
Kamari Moulton	RB	261 YDS / 2 TD / 65.3 YPG / 5.2 YPC 9 REC / 71 REC YDS / 0 REC TD / 23.7 REC YPG
Xavier Williams	RB	241 YDS / 3 TD / 60.3 YPG / 7.3 YPC
Kaden Wetjen	WR	11 REC / 59 YDS / 1 TD / 11.8 YPG
Jaden Harrell	LB	33 TKL / 1 TFL / 1 SACK
Max Llewellyn	DL	12 TKL / 5 TFL / 5 SACK
Zach Lutmer	DB	29 TKL / 2 TFL / 1 SACK / 1 INT
Karson Sharar	LB	36 TKL / 1 TFL / 1 SACK

Penn State 2025 Key Players

Name	Position	Stats
Drew Allar	QB	1,100 YDS (64.8%) / 8 TD / 3 INT 172 RUSH YDS / 1 RUSH TD / 28.7 RUSH YPG
Kaytron Allen	RB	467 YDS / 7 TD / 77.8 YPG / 6.7 YPC
Nicholas Singleton	RB	259 YDS / 6 TD / 43.2 YPG / 3.7 YPC 12 REC / 95 REC YDS / 0 REC TD / 15.8 REC YPG
Devonte Ross	WR	16 REC / 240 YDS / 3 TD / 40 YPG
Amare Campbell	LB	49 TKL / 5 TFL / 2 SACK
Zakee Wheatley	DB	39 TKL / 1 TFL
Dani Dennis-Sutton	DL	23 TKL / 4 TFL / 2 SACK
Tony Rojas	LB	24 TKL / 4 TFL / 2 SACK