Iowa vs. Michigan State Prediction, Odds, Picks - November 22, 2025

Updated Nov. 22, 2025 3:04 p.m. ET

Data Skrive

The Iowa Hawkeyes (6-4) host the Michigan State Spartans (3-7) on Saturday, November 22, 2025 in a matchup between Big Ten foes at Kinnick Stadium. Michigan State is a 17.5-point underdog. The point total is set at 42.5.

Last time out, the Hawkeyes fell to the USC Trojans, with 26-21 being the final score. The Spartans lost to the Penn State Nittany Lions, 28-10, in their most recent contest.

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Iowa vs. Michigan State Game Information & Odds

When: Saturday, November 22, 2025 at 3:30 p.m. ET
Location: Kinnick Stadium in Iowa City, Iowa
TV: FS1
Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Iowa vs Michigan State Betting Information updated as of November 22, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Iowa	-17.5 (-107)	-1000	+651	42.5	-109	-111

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Iowa vs. Michigan State Prediction

Pick ATS: Iowa (-17.5)
Pick OU: Over (42.5)
Prediction: Iowa 35, Michigan State 13

Predictions are made by the Data Skrive betting model.

Learn more about the Iowa Hawkeyes vs. the Michigan State Spartans game on FOX Sports!

Iowa vs. Michigan State Betting Insights

Per the spread and over/under, the implied score for the tilt is Hawkeyes 30, Spartans 12.
The Hawkeyes have a 90.9% chance to collect the win in this meeting based on the moneyline's implied probability. The Spartans hold a 13.3% implied probability.
Iowa has won seven games against the spread this season, while failing to cover or pushing three times.
Michigan State has compiled a 5-5-0 record against the spread this year.

Iowa vs. Michigan State: Head-to-Head

The last two times Michigan State and Iowa have squared off, the two teams share the same 1-1 record.
The Spartans own a 2-0 record ATS in those games, while the two teams went over the total both times.
Iowa has been outpaced by 2 points in its last two tilts versus Michigan State.

Iowa vs. Michigan State: 2025 Stats Comparison

	Iowa	Michigan State
Off. Points per Game (Rank)	28.7 (64)	24 (97)
Def. Points per Game (Rank)	14.9 (9)	31.1 (107)
Turnovers Allowed (Rank)	9 (13)	10 (25)
Turnovers Forced (Rank)	12 (72)	6 (129)

Iowa 2025 Key Players

Name	Position	Stats
Mark Gronowski	QB	1,216 YDS (63.9%) / 6 TD / 5 INT 370 RUSH YDS / 13 RUSH TD / 37 RUSH YPG
Kamari Moulton	RB	612 YDS / 2 TD / 76.5 YPG / 5.1 YPC 13 REC / 81 REC YDS / 0 REC TD / 13.5 REC YPG
Kaden Wetjen	WR	20 REC / 151 YDS / 1 TD / 16.8 YPG
Xavier Williams	RB	258 YDS / 3 TD / 32.3 YPG / 6.1 YPC
Zach Lutmer	DB	55 TKL / 3 TFL / 1 SACK / 2 INT
Xavier Nwankpa	DB	59 TKL / 0 TFL / 1 INT / 1 PD
Karson Sharar	LB	62 TKL / 4 TFL / 1 SACK
Aaron Graves	DL	33 TKL / 6 TFL / 5 SACK / 1 INT

Michigan State 2025 Key Players

Name	Position	Stats
Aidan Chiles	QB	1,392 YDS (63.1%) / 10 TD / 3 INT 227 RUSH YDS / 6 RUSH TD / 28.4 RUSH YPG
Nick Marsh	WR	48 REC / 559 YDS / 5 TD / 55.9 YPG
Makhi Frazier	RB	520 YDS / 2 TD / 57.8 YPG / 4.5 YPC
Omari Kelly	WR	41 REC / 544 YDS / 1 TD / 54.4 YPG
Jordan Hall	LB	73 TKL / 3 TFL / 2 SACK / 1 INT
Malik Spencer	DB	42 TKL / 3 TFL / 2 SACK
Wayne Matthews III	LB	57 TKL / 2 TFL / 1 INT / 1 PD
Armorion Smith	DB	34 TKL / 1 TFL / 1 INT / 1 PD