Arizona State vs. Houston Prediction, Odds, Picks - October 25, 2025

The No. 24 Arizona State Sun Devils (5-2) host the Houston Cougars (6-1) on Saturday, October 25, 2025 in a matchup between Big 12 rivals at Mountain America Stadium. Houston is a touchdown underdog. The over/under is 46.5 for the outing.

In their most recent game, the Sun Devils won against the Texas Tech Red Raiders, 26-22. Last time out, the Cougars defeated the Arizona Wildcats, with 31-28 being the final score.

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Arizona State vs. Houston Game Information & Odds

• When: Saturday, October 25, 2025 at 8 p.m. ET
• Location: Mountain America Stadium in Tempe, Arizona
• TV: ESPN2
• Live Box Score on FOX Sports

Arizona State vs. Houston Prediction

• Pick ATS: Arizona State (-7)
  
• Pick OU: Over (46.5)
  
• Prediction: Arizona State 30, Houston 21

Predictions are made by the Data Skrive betting model.

Learn more about the Arizona State Sun Devils vs. the Houston Cougars game on FOX Sports!

Arizona State vs. Houston Betting Insights

• Based on the spread and over/under, the implied score for the game is Sun Devils 27, Cougars 20.
• The Sun Devils have a 73.3% chance to win this contest per the moneyline's implied probability. The Cougars hold a 31.2% implied probability.
• Arizona State has covered three times in seven chances against the spread this season.
• Houston has put together a 5-2-0 ATS record so far this year.

Arizona State vs. Houston: 2025 Stats Comparison

Arizona State 2025 Key Players

Houston 2025 Key Players

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Arizona State Sun Devils

Houston Cougars

College Football