Arizona State vs. Houston Prediction, Odds, Picks - October 25, 2025

Updated Oct. 25, 2025 3:04 p.m. ET

FOX Sports

The No. 24 Arizona State Sun Devils (5-2) host the Houston Cougars (6-1) on Saturday, October 25, 2025 in a matchup between Big 12 rivals at Mountain America Stadium. Houston is a touchdown underdog. The over/under is 46.5 for the outing.

In their most recent game, the Sun Devils won against the Texas Tech Red Raiders, 26-22. Last time out, the Cougars defeated the Arizona Wildcats, with 31-28 being the final score.

Keep up with college football all season on FOX Sports.

Arizona State vs. Houston Game Information & Odds

When: Saturday, October 25, 2025 at 8 p.m. ET
Location: Mountain America Stadium in Tempe, Arizona
TV: ESPN2
Live Box Score on FOX Sports

Arizona State vs Houston Betting Information updated as of October 25, 2025, 1:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Arizona State	-7 (-109)	-275	+221	46.5	-111	-109

Arizona State vs. Houston Prediction

Pick ATS: Arizona State (-7)
Pick OU: Over (46.5)
Prediction: Arizona State 30, Houston 21

Predictions are made by the Data Skrive betting model.

Learn more about the Arizona State Sun Devils vs. the Houston Cougars game on FOX Sports!

Arizona State vs. Houston Betting Insights

Based on the spread and over/under, the implied score for the game is Sun Devils 27, Cougars 20.
The Sun Devils have a 73.3% chance to win this contest per the moneyline's implied probability. The Cougars hold a 31.2% implied probability.
Arizona State has covered three times in seven chances against the spread this season.
Houston has put together a 5-2-0 ATS record so far this year.

Arizona State vs. Houston: 2025 Stats Comparison

	Arizona State	Houston
Off. Points per Game (Rank)	26 (85)	29.4 (60)
Def. Points per Game (Rank)	24.3 (68)	19 (30)
Turnovers Allowed (Rank)	4 (7)	4 (7)
Turnovers Forced (Rank)	10 (40)	8 (70)

Arizona State 2025 Key Players

Name	Position	Stats
Sam Leavitt	QB	1,358 YDS (62.3%) / 9 TD / 3 INT 284 RUSH YDS / 5 RUSH TD / 47.3 RUSH YPG
Jordyn Tyson	WR	57 REC / 628 YDS / 8 TD / 89.7 YPG
Raleek Brown	RB	642 YDS / 3 TD / 91.7 YPG / 5.8 YPC 25 REC / 139 REC YDS / 0 REC TD / 19.9 REC YPG
Chamon Metayer	TE	21 REC / 226 YDS / 1 TD / 37.7 YPG
Keyshaun Elliott	LB	53 TKL / 7 TFL / 4 SACK
Jordan Crook	LB	47 TKL / 5 TFL / 2 SACK
Myles Rowser	DB	48 TKL / 3 TFL
Adrian Wilson	DB	34 TKL / 1 TFL / 1 INT / 1 PD

Houston 2025 Key Players

Name	Position	Stats
Conner Weigman	QB	1,380 YDS (62%) / 11 TD / 2 INT 246 RUSH YDS / 6 RUSH TD / 35.1 RUSH YPG
Dean Connors	RB	538 YDS / 4 TD / 76.9 YPG / 4.7 YPC 16 REC / 113 REC YDS / 1 REC TD / 16.1 REC YPG
Amare Thomas	WR	27 REC / 510 YDS / 4 TD / 72.9 YPG
Tanner Koziol	TE	36 REC / 350 YDS / 3 TD / 50 YPG
Jalen Garner	LB	33 TKL / 1 TFL / 2 SACK
Wrook Brown	DB	18 TKL / 4 TFL / 2.5 SACK / 1 INT
Latreveon McCutchin	LB	24 TKL / 1 TFL / 1 SACK / 1 INT
Carlos Allen	DL	25 TKL / 2 TFL / 1 SACK