Alabama vs. Missouri Prediction, Odds, Picks - October 11, 2025

Updated Oct. 11, 2025 9:04 a.m. ET

Data Skrive

The No. 14 Missouri Tigers (5-0) and the ninth-ranked passing defense will host the No. 8 Alabama Crimson Tide (4-1) and the fifth-ranked pass offense on Saturday, October 11, 2025. The Tigers are 3.5-point underdogs. The over/under for the outing is set at 51.5.

The Crimson Tide beat the Vanderbilt Commodores, 30-14, in their most recent game. In their last game, the Tigers won against the UMass Minutemen, 42-6.

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Alabama vs. Missouri Game Information & Odds

When: Saturday, October 11, 2025 at 12 p.m. ET
Location: Memorial Stadium/Faurot Field in Columbia, Missouri
TV: ABC
Live Box Score on FOX Sports

Alabama vs Missouri Betting Information updated as of October 11, 2025, 8:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Alabama	-3.5 (-105)	-168	+141	51.5	-110	-110

Alabama vs. Missouri Prediction

Pick ATS: Alabama (-3.5)
Pick OU: Over (51.5)
Prediction: Alabama 34, Missouri 21

Predictions are made by the Data Skrive betting model.

Learn more about the Alabama Crimson Tide vs. the Missouri Tigers game on FOX Sports!

Alabama vs. Missouri Betting Insights

Based on the spread and over/under, the implied score for the matchup is Crimson Tide 28, Tigers 24.
The Crimson Tide have a 62.7% chance to win this game per the moneyline's implied probability. The Tigers have a 41.5% implied probability.
Alabama has won four games against the spread this season, while failing to cover once.
Missouri has put together a 3-2-0 ATS record so far this year.

Alabama vs. Missouri: 2025 Stats Comparison

	Alabama	Missouri
Off. Points per Game (Rank)	36.4 (39)	45.2 (13)
Def. Points per Game (Rank)	16 (19)	14.6 (14)
Turnovers Allowed (Rank)	1 (2)	4 (18)
Turnovers Forced (Rank)	9 (22)	4 (106)

Alabama 2025 Key Players

Name	Position	Stats
Ty Simpson	QB	1,478 YDS (70.3%) / 13 TD / 1 INT 51 RUSH YDS / 2 RUSH TD / 10.2 RUSH YPG
Germie Bernard	WR	25 REC / 392 YDS / 5 TD / 78.4 YPG
Ryan Williams	WR	21 REC / 336 YDS / 3 TD / 84 YPG
Isaiah Horton	WR	18 REC / 236 YDS / 3 TD / 47.2 YPG
Justin Jefferson	LB	29 TKL / 1 TFL / 1 SACK / 1 INT
Bray Hubbard	DB	20 TKL / 1 TFL / 2 INT / 2 PD
Keon Sabb	DB	14 TKL / 1 TFL / 1 SACK / 1 INT
Lebbeus Thomas Overton	DL	14 TKL / 2 TFL / 1.5 SACK

Missouri 2025 Key Players

Name	Position	Stats
Ahmad Hardy	RB	730 YDS / 9 TD / 146 YPG / 7.1 YPC
Beau Pribula	QB	1,203 YDS (75.9%) / 9 TD / 3 INT 121 RUSH YDS / 3 RUSH TD / 24.2 RUSH YPG
Jamal Roberts	RB	350 YDS / 3 TD / 70 YPG / 7.3 YPC 6 REC / 71 REC YDS / 1 REC TD / 17.8 REC YPG
Kevin Coleman Jr.	WR	39 REC / 386 YDS / 1 TD / 77.2 YPG
Zion Young	DL	13 TKL / 4 TFL / 2 SACK
Josiah Trotter	LB	26 TKL / 5 TFL
Damon Wilson Jr.	DL	7 TKL / 3 TFL / 3.5 SACK
Khalil Jacobs	LB	12 TKL / 3 TFL / 2 SACK