Houston vs. Purdue Prediction, Odds, Picks - NCAA Tournament Sweet 16

Updated Mar. 28, 2025 8:27 p.m. ET

Data Skrive

A Sweet 16 NCAA Tournament matchup features the No. 1 Houston Cougars (32-4) and No. 4 Purdue Boilermakers (24-11) to decide which of the squads is heading to the Midwest regional final when it tips off on Friday at Lucas Oil Stadium, starting at 10:09 p.m. ET, airing on TBS.

The Cougars are an 8.5-point favorite against the Boilermakers when the Cougars and the Boilermakers square off. The matchup features a point total of 134.5.

Keep scrolling to get all the information before placing bets on the Houston-Purdue clash.

Houston vs. Purdue Game Information & Odds

When: Friday, March 28, 2025 at 10:09 p.m. ET
Where: Lucas Oil Stadium in Indianapolis, Indiana
How to watch on TV: TBS
Live boxscore on FOX Sports

Cougars vs Boilermakers Betting Information
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds	Favorite Moneyline	Underdog Moneyline
Cougars	-8.5	-110	-110	134.5	-105	-115	-455	+350

Houston vs. Purdue Prediction

Pick ATS: Purdue (+8.5)
Pick OU: Over (134.5)
Prediction: Houston 74, Purdue 67

Learn more about the Houston Cougars vs. the Purdue Boilermakers game on FOX Sports!

Houston vs. Purdue Betting Insights

Betting Line Implied Predictions

Per the spread and over/under, the implied score for the matchup is Cougars 72, Boilermakers 63.
The Cougars have an 82.0% chance to win this meeting based on the moneyline's implied probability.
The Boilermakers hold a 22.2% implied probability to win.

Key Spread Facts

Houston has covered 19 times in 35 chances against the spread this season.
Purdue is 19-15-0 ATS this season.
Houston is 14-12 ATS this season when playing as at least 8.5-point favorites.
Purdue has not covered the spread this season (0-1 ATS) when playing as at least 8.5-point underdogs.

Key Total Facts

A total of 17 times so far this season, the Cougars and their opponent have combined for more than 134.5 points.
Boilermakers games have had over 134.5 points 26 times this year.
These teams score 152.2 points per game combined, higher than the over/under for this matchup by 17.7.

Key Moneyline Facts

Houston has won 87.5% of its games this season when favored on the moneyline (28-4).
This season, Purdue has been the underdog eight times and won two of those games.
When it has played as a moneyline favorite with odds of -455 or shorter, Houston has a record of 21-2 (91.3% win percentage).
Purdue has played as an underdog of +350 or more once this season and lost that game.

Houston vs. Purdue: 2024-25 Stats Comparison

	Houston	Purdue
Points Scored Per Game (Rank)	74.5 (154)	77.7 (79)
Points Allowed (Rank)	58.4 (1)	70.6 (134)
Rebounds (Rank)	10.9 (37)	8.5 (208)
3pt Made (Rank)	8.1 (134)	8.3 (111)
Assists (Rank)	12.1 (286)	15.8 (46)
Turnovers (Rank)	8.6 (5)	10 (69)

Houston 2024-25 Key Players

Cougars Leaders
Name	GP	PTS	REB	ASST	STL	BLK	3PM
LJ Cryer	36	15.6	2.2	1.9	0.9	0.1	3.1
Emanuel Sharp	33	12.5	3	0.8	1.4	0	2.3
Milos Uzan	36	11.5	3	4.3	1	0.1	1.5
J'wan Roberts	33	10.9	6.3	1.7	1	0.7	0
Terrance Arceneaux	36	7	2.8	0.8	1	0.3	0.7

Purdue 2024-25 Key Players

Boilermakers Leaders
Name	GP	PTS	REB	ASST	STL	BLK	3PM
Trey Kaufman-Renn	35	20.3	6.5	2.2	0.7	0.3	0.1
Braden Smith	35	16	4.5	8.5	2.2	0.2	2.3
Fletcher Loyer	35	13.7	2.1	1.8	0.5	0	2.1
Daniel Jacobsen	2	6.5	3.5	0	0	1.5	0
C.J. Cox	35	6	2.8	0.7	0.7	0	0.9