Ravens vs. Lions 2025 Prediction, Odds, Picks - Sep 22

The Baltimore Ravens (1-1) are considered favorites (-4.5) according to the point spread ahead of their game versus the Detroit Lions (1-1) on September 22, 2025, starting at 8:15 p.m. ET, airing on ABC/ESPN. The matchup has an over/under of 54.5 points.

Keep up with the 2025 NFL season on FOX Sports.

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Ravens vs. Lions Odds & Betting Lines

Ravens vs. Lions Prediction & Pick

• Pick ATS: Lions (+4.5)
  
• Pick OU: Under (54.5)
  
• Prediction: Ravens 27 - Lions 26

How to Watch Baltimore vs. Detroit

• Game date: Monday, September 22, 2025
• Time: 8:15 p.m. ET
• Venue: M&T Bank Stadium
• Location: Baltimore, Maryland
• TV: ABC/ESPN
• Live Boxscore: FOX Sports

Ravens vs. Lions Recent Matchups

• Baltimore has a 3-0 record against Detroit in their last three matchups.
• Detroit has been outscored by 58 points in its last three tilts versus Baltimore.

Baltimore Betting Info

• This season, Baltimore has one win against the spread.
• The Ravens have won their only game this season when playing as at least 4.5-point favorites.
• Baltimore games this year have hit the over on two of two set point totals (100%).
• The Ravens have been moneyline favorites two other times this season, and they split them.
• The Ravens have an implied win probability, based on the moneyline, of 69.7%.

Ravens Stats

Baltimore's Key Players

Offense

• Lamar Jackson has passed for 434 yards, six touchdowns (third in the NFL) and zero interceptions this year. He is averaging 217 yards per game and 9 per attempt, while completing 68.8% of his attempts.
• To go along with his passing statistics, Jackson has 83 rushing yards (second on the Ravens), with one rushing touchdown.
• Derrick Henry's rushing statline this season includes 192 yards and two TDs. He is averaging 96 yards per game and 6.6 per attempt (first in the NFL).
• In the passing attack, Zay Flowers, has racked up 218 receiving yards and one touchdown after hauling in 14 balls on 20 targets. Per game, he's averaging 109 yards and seven receptions over two games.
• DeAndre Hopkins has racked up 99 receiving yards and two touchdowns (seventh in the NFL) with four catches on four targets. He is averaging two receptions and 49.5 yards per game.

Defense

• On the defensive side, Roquan Smith has 25 tackles and three TFL in 2025.
• Kyle Hamilton has one TFL and 14 tackles.
• Tavius Robinson has recorded 11 tackles, one TFL, and one sack this year.
• Nnamdi Madubuike has seven tackles, two TFL, and two sacks.

Detroit Betting Info

• Detroit is 1-1-0 against the spread this season.
• This season, Detroit games have hit the over just once.
• The Lions lost the only game they've played as the underdog this season.
• The bookmakers' moneyline implies a 34.5% chance of a victory for the Lions.

Lions Stats

Detroit's Key Players

Offense

• Jared Goff has thrown for 559 yards this year, with six touchdowns (third in the NFL) and one interception. He is completing 80.6% of his passes while averaging 279.5 yards per game and 8.3 per attempt.
• Amon-Ra St. Brown has put together a 2025 campaign that includes 13 catches for 160 yards and three receiving touchdowns (third in the NFL) through two games played. He has been on the receiving end of 17 targets and is averaging 6.5 receptions per game.
• So far this season through two games, Jahmyr Gibbs has racked up 113 rushing yards (leading the Lions) and scored one rushing touchdown. He averages 56.5 yards per game and 5.4 per carry (seventh in the NFL).
• Gibbs has helped out in the passing game, amassing 41 receiving yards (20.5 per game) on 13 catches (6.5 per game), while being targeted 13 times. He is looking for his first receiving touchdown.
• Jameson Williams has been targeted nine times, resulting in six catches for 131 yards .

Defense

• In 2025, Brian Branch has amassed 11 tackles, three TFL, and one sack over two games.
• Jack Campbell has 17 tackles.
• Terrion Arnold has 12 tackles.
• Derrick Barnes' stat sheet includes 12 tackles and one TFL in two games

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Baltimore Ravens

Detroit Lions