Rams vs. Colts 2025 Prediction, Odds, Picks - Sep 28

Having won three in a row, the Indianapolis Colts (3-0) will play the Los Angeles Rams (2-1). Despite that, the Rams are the favorites, expected to win by at least a field goal but less than a touchdown (currently -3.5). The expected point total for the matchup is set at 50.5.

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Rams vs. Colts Odds & Betting Lines

Rams vs. Colts Prediction & Pick

• Pick ATS: Rams (-3.5)
  
• Pick OU: Under (50.5)
  
• Prediction: Rams 29 - Colts 17

How to Watch Los Angeles vs. Indianapolis

• Game date: Sunday, September 28, 2025
• Time: 4:05 p.m. ET
• Venue: SoFi Stadium
• Location: Inglewood, California
• TV: Watch on FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Rams vs. Colts Recent Matchups

• Over their last three meetings, Los Angeles has tallied three wins versus Indianapolis.
• In their last three head-to-head matchups, Los Angeles has compiled 102 points versus Indianapolis, while surrendering only 56 points.

Los Angeles Betting Info

• So far this season Los Angeles has two victories against the spread.
• The Rams have won each of their two games this season when playing as at least 3.5-point favorites.
• Los Angeles games this year have hit the over on two of three set point totals (66.7%).
• The Rams have been moneyline favorites in two other games this season, and they won both.
• The Rams have a 65.8% chance to win this matchup, based on the implied probability of the moneyline.

Rams Stats

Los Angeles' Key Players

Offense

• Matthew Stafford has 739 passing yards in three games this year, averaging 246.3 per game with a 66.3% completion percentage and five touchdowns (eighth in the NFL) against two interceptions.
• Puka Nacua has 29 catches (first in the NFL) for 333 yards (second in the NFL) and zero TDs. Through three games, he is averaging 9.7 catches and 111 yards per game.
• Kyren Williams has 226 rushing yards (ninth in the NFL) with one touchdown (75.3 yards per game through three games).
• Williams has recorded five receptions, 35 yards and one TD through the air.
• Davante Adams has 13 receptions for 213 yards and two touchdowns. He's been targeted 29 times in the air attack, and averages 4.3 receptions and 71 yards in three games played.

Defense

• On defense, Byron Young has 20 tackles, six TFL, and four sacks in 2025.
• Kamren Curl has 26 tackles, two TFL, and one sack this season. He leads the Rams in tackles.
• Nathan Landman has put up 21 tackles this year.
• Jared Verse has one sack (third on the Rams) to go with his two TFL and 11 tackles this year.

Indianapolis Betting Info

• Indianapolis has covered in each of the three opportunities it has had with a set spread this year (3-0-0).
• Indianapolis games have gone over the total twice this season.
• The Colts won the only game they've played as the underdog this season.
• The sportsbooks' moneyline implies a 38.5% chance of a victory for the Colts.

Colts Stats

Indianapolis' Key Players

Offense

• In three games played this year, Daniel Jones has racked up 816 passing yards (fourth-best in the NFL), while throwing three touchdowns against zero interceptions and completing 71.6% of his passes.
• On the ground, Jones has added three rushing touchdowns and 55 rushing yards (second on the Colts).
• Jonathan Taylor averages 112.7 rushing yards per game through three games (338 total yards to rank first in the NFL), while scoring three rushing touchdowns.
• Taylor has also picked up 93 receiving yards (31 per game) on eight catches (2.7 per game). He's been targeted nine times and has caught one touchdown pass.
• In three games played this season, Michael Pittman Jr. has 16 catches (5.3 receptions per game on 6.3 targets per game) for 193 yards and two receiving touchdowns (seventh in the NFL).
• Tyler Warren has 193 receiving yards from 14 receptions after receiving 21 targets.

Defense

• Nick Cross has amassed one sack (second on the Colts) to go with two TFL and 20 tackles through three games in 2025.
• Kenny Moore II's stat sheet includes one interception (eighth in the NFL) as well as 10 tackles, one TFL, one sack, and two passes defended.
• Camryn Bynum has 11 tackles and two interceptions in the 2025 season.
• DeForest Buckner's stat sheet includes 14 tackles and two TFL in three games

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Los Angeles Rams

Indianapolis Colts