Rams vs. 49ers 2025 Prediction, Odds, Picks - Oct 2

In a matchup of two division rivals, the Los Angeles Rams (3-1) will play the San Francisco 49ers (3-1). The Rams are solid favorites, expected to win by at least a touchdown (currently -8.5). The expected point total for the matchup is set at 44.5.

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Rams vs. 49ers Odds & Betting Lines

Rams vs. 49ers Prediction & Pick

• Pick ATS: 49ers (+8.5)
  
• Pick OU: Under (44.5)
  
• Prediction: Rams 23 - 49ers 19

How to Watch Los Angeles vs. San Francisco

• Game date: Thursday, October 2, 2025
• Time: 8:15 p.m. ET
• Venue: SoFi Stadium
• Location: Inglewood, California
• TV: Amazon Prime Video
• Live Boxscore: FOX Sports

Rams vs. 49ers Recent Matchups

• Los Angeles owns a 3-2 record against San Francisco in their last five matchups.
• Los Angeles has been outscored by 14 points in its last five tilts versus San Francisco.

Los Angeles Betting Info

• Los Angeles has three wins in four games versus the spread this season.
• Los Angeles games this year have gone over the total in two out of four opportunities (50%).
• The Rams have won each of the three games they were favored on the moneyline this season.
• The implied probability for this matchup, considering the moneyline, gives the Rams an 82.9% chance to win.

Rams Stats

Los Angeles' Key Players

Offense

• Matthew Stafford has 1,114 passing yards (second in the NFL), eight touchdowns (third in the NFL) and two interceptions this year. He has completed 67.6% of his attempts, averaging 278.5 yards per game and 8.2 per attempt.
• Puka Nacua has caught 42 passes (first in the NFL) on 50 targets for 503 total yards (first in the NFL) and one touchdown. He is averaging 10.5 catches and 125.8 yards per game in four games.
• Kyren Williams' output on the ground this season includes 303 yards (seventh in the NFL) and one TD. He is averaging 75.8 yards per game and 4.5 per attempt (20th in the NFL).
• Williams has been on the receiving end of 11 targets in the passing game and has eight catches (two per game) for 52 yards (13 per game) and one TD.
• Davante Adams averages 4.3 receptions and 67.3 yards per game, and has 269 total receiving yards and 17 catches. He's gotten 35 total targets, and has caught three touchdown passes (eighth in the NFL).

Defense

• On the defensive side, Byron Young has five sacks (first in the NFL) to go with seven TFL and 23 tackles in 2025.
• Kamren Curl has intercepted two pases (third in the NFL) and added 35 tackles, two TFL, one sack, and three passes defended.
• This season, Jared Verse has recorded two sacks (second on the Rams) to go along with his three TFL and 17 tackles.
• Nathan Landman has 27 tackles and one pass defended.

San Francisco Betting Info

• San Francisco has covered the spread two times this season (2-2-0).
• Games involving San Francisco have hit the over twice this year.
• The 49ers will play as the underdog for the first time this season.
• Bookmakers have implied with the moneyline set for this matchup that the 49ers have a 21.3% chance to win.

49ers Stats

San Francisco's Key Players

Offense

• Christian McCaffrey has not scored a rushing touchdown this year, but has accumulated 225 total rushing yards (56.3 per game and 3.3 per carry).
• On top of his impact in the run game, McCaffrey has caught 31 passes (on 43 targets) for 305 yards (second on the 49ers and eighth in the NFL), with two receiving touchdowns. He's averaging 76.3 yards per game.
• In two games, Mac Jones has 563 passing yards, with four touchdowns against one interception and completing 66.3% of his attempts.
• Through two games this season, Brock Purdy has racked up 586 passing yards, while throwing four touchdowns against four interceptions and completing 65.8% of his passes.
• Purdy has also rushed for 30 yards (third on the 49ers).
• Ricky Pearsall has 327 receiving yards (fourth in the NFL) from 20 receptions after receiving 29 targets.

Defense

• Fred Warner's 2025 effort includes 38 tackles and two TFL through four games. He leads the 49ers and is seventh in the NFL in tackles.
• Dee Winters has 32 tackles and three TFL. He is second on the 49ers in tackles.
• Over the 2025 campaign, Marques Sigle has 26 tackles in four games.
• Bryce Huff's stat sheet includes 11 tackles, three TFL, two sacks, and one pass defended in four games

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Los Angeles Rams

San Francisco 49ers