Rams vs. 49ers 2025 Prediction, Odds, Picks - Nov 9

Having won three in a row, the Los Angeles Rams (6-2) will play the San Francisco 49ers (6-3). The Rams are the favorites, expected to win by at least a field goal but less than a touchdown (currently -5.5). The expected point total for the game is 49.5.

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Rams vs. 49ers Odds & Betting Lines

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Rams vs. 49ers Prediction & Pick

• Pick ATS: 49ers (+5.5)
  
• Pick OU: Under (49.5)
  
• Prediction: Rams 24 - 49ers 19

How to Watch Los Angeles vs. San Francisco

• Game date: Sunday, November 9, 2025
• Time: 4:25 p.m. ET
• Venue: Levi's Stadium
• Location: Santa Clara, California
• TV: Watch on FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Rams vs. 49ers Recent Matchups

• Los Angeles owns a 3-2 record against San Francisco in their last five matchups.
• Los Angeles and San Francisco have matched up evenly on offense over their last five matchups, with each team putting up 106 points in those games.

Los Angeles Betting Info

• In eight Los Angeles games this season, it has six wins against the spread.
• When playing as at least 5.5-point favorites this season, the Rams have an ATS record of 3-1.
• Los Angeles has combined with its opponent to hit the over in 37.5% of its contests this year (three times in eight games with a set point total).
• When playing as the moneyline favorite, the Rams are 6-1, winning 85.7% of the time.
• The Rams have a 71.4% chance to win this contest, based on the implied probability of the moneyline.

Rams Stats

Los Angeles' Key Players

Offense

• Matthew Stafford has passed for 2,147 yards (sixth in the NFL), 21 touchdowns (first in the NFL) and two interceptions this year. He averages 268.4 yards per game and 7.8 per attempt, while completing 67.2% of his passes.
• Kyren Williams' rushing statline this season includes 586 yards and three TDs. He's averaging 73.3 yards per game and 4.4 per attempt (22nd in the NFL).
• Williams has 20 catches on 26 targets for 166 yards. He has three receiving TDs.
• Puka Nacua has three touchdown catches this season, and has 61 catches (second in the NFL) for 711 yards (fourth in the NFL) on 73 targets, while averaging 8.7 catches and 101.6 yards per game.
• Davante Adams averages 4.5 receptions and 61.4 yards per game, and has 491 total receiving yards and 36 catches. He's gotten 70 total targets, and has caught eight touchdown passes (first in the NFL).

Defense

• On defense for the Rams, Byron Young has put up 41 tackles, nine TFL, and nine sacks in 2025.
• Nathan Landman has 72 tackles, two TFL, 1.5 sacks, and four passes defended.
• This season, Jared Verse has recorded four sacks (second on the Rams) as well as seven TFL and 32 tackles.
• So far this season, Kamren Curl has 61 tackles, two TFL, one sack, and two interceptions.

San Francisco Betting Info

• San Francisco is 5-4-0 against the spread this year.
• The 49ers covered the spread in their only game when underdogs by 5.5 points or more.
• This season, San Francisco games have hit the over five times.
• The 49ers have entered the game as underdogs three times this season and won once.
• The 49ers have a 32.8% chance to win this game based on the implied probability of the moneyline.

49ers Stats

San Francisco's Key Players

Offense

• Christian McCaffrey averages 66.2 rushing yards per game this year (596 total yards to rank ninth in the NFL), while scoring four rushing touchdowns.
• McCaffrey's contributions include 61 receptions (6.8 per game) on 80 targets for 626 yards (69.6 per game) and four receiving touchdowns.
• In seven games, Mac Jones has 1,832 passing yards, with 10 touchdowns against five interceptions and completing 67.2% of his passes.
• Jake Tonges has totaled 226 receiving yards and four touchdowns on 26 receptions, while being targeted 35 times on the season.
• Kendrick Bourne has 30 catches for 463 yards without a receiving touchdown. He averages 3.8 yards per game through eight games and has been targeted 41 times.

Defense

• In 2025, Dee Winters has put up four TFL and 59 tackles through nine games.
• Bryce Huff has 19 tackles, six TFL, four sacks, and one pass defended.
• Marques Sigle has 45 tackles and one TFL in the 2025 season. He is fourth on the 49ers in tackles.
• Tatum Bethune's stats include 51 tackles, one TFL, and one pass defended in seven games

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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San Francisco 49ers

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