Packers vs. Lions 2025 Prediction, Odds, Picks - Sep 7

The Green Bay Packers (0-0) and Detroit Lions (0-0) will play each other in a battle of two division rivals. The Packers are slight favorites (-1.5). An over/under of 48.5 points has been established for the matchup.

Keep up with the 2025 NFL season on FOX Sports.

Matthew Stafford nearly a Giant? Jay Glazer breaks it down | FOX NFL Kickoff

Jay Glazer revealed the Rams nearly traded Matthew Stafford before extending him, with Aaron Rodgers as their backup plan. He also shared how the Micah Parsons trade came together behind the scenes.

Packers vs. Lions Odds & Betting Lines

Packers vs. Lions Prediction & Pick

• Pick ATS: Lions (+1.5)
  
• Pick OU: Over (48.5)
  
• Prediction: Lions 27 - Packers 24

How to Watch Green Bay vs. Detroit

• Game date: Sunday, September 7, 2025
• Time: 4:25 p.m. ET
• Venue: Lambeau Field
• Location: Green Bay, Wisconsin
• TV: CBS
• Live Boxscore: FOX Sports

Packers vs. Lions Recent Matchups

• In their last five head-to-head bouts, Detroit has won against Green Bay four times.
• Over their last five head-to-head matchups, Detroit has put up 134 points, while Green Bay has posted 110.

Green Bay Betting Info

• Green Bay covered eight times in 17 games with a spread last season.
• The Packers had an ATS record of 6-5 as 1.5-point favorites or greater last season.
• Last season, the combined scoring went over the point total eight times in Green Bay games.
• The Packers put together a 9-3 record in games they were favored on the moneyline last season (winning 75% of those games).
• Green Bay had a 9-2 record last year (winning 81.8% of its games) when playing as a moneyline favorite of -125 or shorter.
• The implied moneyline probability for this matchup gives the Packers a 55.6% chance to win.

Packers Stats (2024)

Green Bay's Key Players

Offense

• Josh Jacobs rushed for 15 touchdowns last year, and accumulated 1,329 total rushing yards (78.2 per game and 4.4 per carry).
• Jacobs' contributions include 36 receptions (2.1 per game) on 43 targets for 342 yards (20.1 per game) and one receiving touchdown.
• In 15 games, Jordan Love had 3,389 passing yards, while throwing 25 touchdowns (10th in the NFL) against 11 interceptions and completing 63.1% of his attempts.
• Love also had one rushing touchdown and 83 rushing yards.
• In 17 games played last season, Jayden Reed had 55 catches (3.2 receptions per game on 4.4 targets per game) for 857 yards and six receiving touchdowns.
• Tucker Kraft was targeted 70 times, resulting in 50 catches for 707 yards.

Defense

• Edgerrin Cooper amassed 3.5 sacks to go with 13 TFL, 77 tackles, and one interception over 14 games in 2024.
• Xavier McKinney's stat sheet included eight interceptions (second in the NFL) as well as 85 tackles, two TFL, one sack, and 11 passes defended.
• During the 2024 campaign, Keisean Nixon had 88 tackles, eight TFL, three sacks, and one interception in 17 games.
• Micah Parsons' season stats for the Cowboys last season include 43 tackles, 12 TFL, and 12 sacks in 13 games.

Detroit Betting Info

• Detroit compiled a 12-4-1 record against the spread last year.
• A total of nine of Detroit's games last year went over the point total.
• The Lions won the only game they played as the underdog last season.
• Detroit was not a bigger underdog last season than the +105 moneyline set for this game.
• The moneyline for this contest implies a 48.8% chance of a victory for the Lions.

Lions Stats (2024)

Detroit's Key Players

Offense

• Jared Goff passed for 4,629 yards last year (second in the NFL), with 37 TDs (fourth in the NFL) and 12 interceptions. He completed 72.4% of his attempts, averaging 272.3 yards per game and 8.6 per attempt.
• Jahmyr Gibbs scored 16 rushing TDs, totaling 1,412 yards (5.6 per carry and 83.1 per game).
• Gibbs also had 52 catches for 517 yards and four receiving TDs. He was targeted 63 times and averaged 30.4 yards per game.
• Amon-Ra St. Brown totaled 1,263 yards receiving (fifth in the NFL) and 12 TDs (third in NFL) on 115 receptions (second in the NFL) while being targeted 141 times last season.
• David Montgomery scored 12 TDs on the ground, while running for 775 total yards (4.2 per attempt and 55.4 per game).
• Montgomery tacked on 36 catches (2.6 per game) for 341 yards (24.4 per game), without a receiving touchdown. He was on the end of 38 targets.

Defense

• Brian Branch intercepted four balls in addition to 109 tackles, eight TFL, one sack, and 16 passes defended in 2024. He was 10th in the league in interceptions.
• Jack Campbell had 1.5 sacks plus five TFL and 125 tackles.
• Kerby Joseph posted one TFL, 82 tackles, and nine interceptions.
• For the Jets, D.J. Reed Jr. amassed64 tackles, four TFL, one sack, and 11 passes defended.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox?

Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

Green Bay Packers

Detroit Lions