Eagles vs. 49ers 2025 Wild Card Round Prediction, Odds, Picks - Jan 11

The Philadelphia Eagles and San Francisco 49ers will feature in the NFC Wild Card round of the 2025 NFL Playoffs. The Eagles are the favorites, expected to win by at least a field goal but less than a touchdown (currently -5.5). The expected point total for the matchup is 44.5.

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Eagles vs. 49ers Odds & Betting Lines

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Eagles vs. 49ers Prediction & Pick

• Pick ATS: 49ers (+5.5)
  
• Pick OU: Over (44.5)
  
• Prediction: 49ers 23 - Eagles 21

How to Watch Philadelphia vs. San Francisco

• Game date: Sunday, January 11, 2026
• Time: 4:30 p.m. ET
• Venue: Lincoln Financial Field
• Location: Philadelphia, Pennsylvania
• TV: Watch on FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Eagles vs. 49ers Recent Matchups

• In their past four matchups, San Francisco has a split 2-2 record against Philadelphia.
• San Francisco has been outpaced by 18 points in its last four tilts versus Philadelphia.

Philadelphia Betting Info

• Against the spread, Philadelphia is 10-7-0 this season.
• The Eagles are 3-3 ATS this season when playing as at least 5.5-point favorites.
• Philadelphia has combined with its opponent to hit the over in 41.2% of its contests this year (seven times in 17 games with a set point total).
• When playing as the moneyline favorite, the Eagles are 9-6 (winning 60% of the time).
• The implied probability for this matchup, considering the moneyline, gives the Eagles a 72.6% chance to win.

Eagles Stats

Philadelphia's Key Players

Offense

• Jalen Hurts has thrown for 3,224 yards, 25 touchdowns (ninth in the NFL) and six interceptions this year. He averages 201.5 yards per game and 7.1 per attempt, while completing 64.8% of his attempts.
• He has also rushed for 421 yards (second on the Eagles) and added eight touchdowns on the ground, while averaging 26.3 rushing yards per game.
• Saquon Barkley averages 4.1 yards per carry (32nd in the NFL) and 71.3 yards per game, and has 1,140 total rushing yards (10th in the NFL). He has recorded seven rushing TDs this season.
• Barkley's 50 targets as part of the passing attack have resulted in 37 catches (2.3 per game) for 273 yards (17.1 per game) and two touchdowns.
• In the passing attack, A.J. Brown, has totaled 1,003 receiving yards and seven touchdowns after hauling in 78 balls on 121 targets. Per game, he's averaging 66.9 yards and 5.2 receptions over 15 games.
• Dallas Goedert averages four receptions and 39.4 yards per game, and has 591 total receiving yards and 60 catches. He's gotten 82 total targets, and has caught 11 touchdown passes (second in the NFL).

Defense

• On defense, Zack Baun has 123 tackles, seven TFL, 3.5 sacks, and two interceptions in 2025. His tackle total leads the Eagles.
• Jalyx Hunt has 6.5 sacks (first on the Eagles) in addition to his nine TFL, 52 tackles, and three interceptions.
• Cooper DeJean has put up 85 tackles, four TFL, and two interceptions this year.
• Jaelan Phillips has 53 tackles, seven TFL, five sacks, and four passes defended.

San Francisco Betting Info

• San Francisco has covered the spread 11 times this season (11-6-0).
• The 49ers have been underdogs by 5.5 points or more two times this year and covered the spread once.
• San Francisco's games have finished with a final combined score above the over/under 10 times this year.
• The 49ers have entered the game as underdogs five times this season and won once.
• The implied probability of a win by the 49ers based on the moneyline is 31.7%.

49ers Stats

San Francisco's Key Players

Offense

• This year in 17 games, Christian McCaffrey has churned out 1,202 rushing yards (leading the 49ers and eighth in the NFL) and scored 10 rushing touchdowns. He averages 70.7 yards per game and 3.9 per attempt (38th in the NFL).
• On top of his impact in the run game, McCaffrey has caught 102 passes (on 129 targets) for 924 yards (first on the 49ers), with seven receiving touchdowns. He's averaging 54.4 yards per game.
• Through nine games, Brock Purdy has 2,167 passing yards, with 20 touchdowns against 10 interceptions and completing 69.4% of his passes.
• Purdy also has three rushing touchdowns and 147 rushing yards (third on the 49ers).
• Mac Jones has thrown for 2,151 yards this year, 13 touchdowns and six interceptions. He is completing 69.6% of his attempts while averaging 195.5 yards per game and 7.4 per attempt.
• Jauan Jennings has 643 receiving yards and nine touchdowns (eighth in the NFL) from 55 receptions after getting 90 targets.

Defense

• Dee Winters' 2025 showing includes 101 tackles, eight TFL, and one interception through 17 games. He leads the 49ers in tackles.
• Upton Stout has one sack in addition to his four TFL and 82 tackles over 16 games.
• Ji'Ayir Brown has intercepted two passes on top of 63 tackles, two TFL, and six passes defended during the 2025 campaign.
• Malik Mustapha has totaled three TFL, 76 tackles, and one interception.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Philadelphia Eagles

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