Chiefs vs. Lions 2025 Prediction, Odds, Picks - Oct 12

The Kansas City Chiefs (2-3) are slight favorites (-2.5) over the Detroit Lions (4-1), despite the Lions having won four games in a row. The matchup has an over/under of 52.5 points.

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Chiefs vs. Lions Odds & Betting Lines

Chiefs vs. Lions Prediction & Pick

• Pick ATS: Lions (+2.5)
  
• Pick OU: Under (52.5)
  
• Prediction: Lions 27 - Chiefs 25

How to Watch Kansas City vs. Detroit

• Game date: Sunday, October 12, 2025
• Time: 8:20 p.m. ET
• Venue: GEHA Field at Arrowhead Stadium
• Location: Kansas City, Missouri
• TV: NBC
• Live Boxscore: FOX Sports

Chiefs vs. Lions Recent Matchups

• In their past two matchups, Detroit has a split 1-1 record against Kansas City.
• Detroit has been outscored by 3 points in its last two tilts versus Kansas City.

Kansas City Betting Info

• Kansas City has two wins versus the spread in five games this year.
• The Chiefs have covered the spread once this season (1-2 ATS) when playing as at least 2.5-point favorites.
• Kansas City games in 2025 have hit the over three times in five opportunities (60%).
• The Chiefs have won 33.3% of the time they have played as moneyline favorites (1-2).
• The Chiefs have an implied win probability, based on the moneyline, of 58.7%.

Chiefs Stats

Kansas City's Key Players

Offense

• Patrick Mahomes has 1,257 passing yards (seventh in the NFL), eight touchdowns (10th in the NFL) and two interceptions this year. He has completed 63.4% of his passes, averaging 251.4 yards per game and 6.9 per attempt.
• He has also rushed for 190 yards (first on the Chiefs) and added three touchdowns on the ground, while averaging 38 rushing yards per game.
• Tyquan Thornton has 13 receptions for 272 yards and three TDs. Through five games, he is averaging 2.6 catches and 54.4 yards per game.
• In five games, Kareem Hunt has amassed 164 rushing yards, averaging 32.8 yards per game and scoring three touchdowns.
• Travis Kelce has 243 receiving yards and two touchdowns with 22 catches on 30 targets. He is averaging 4.4 receptions and 48.6 yards per game.

Defense

• Over on defense, George Karlaftis III has 20 tackles, six TFL, 3.5 sacks, and one pass defended in 2025.
• Nick Bolton has 46 tackles and three TFL this season. He leads the Chiefs in tackles.
• Drue Tranquill has totaled 27 tackles, three TFL, and two sacks this year. He's third on the Chiefs in tackles.
• This season, Jaylen Watson has 27 tackles, one TFL, one sack, and one interception. He's third on the Chiefs in tackles.

Detroit Betting Info

• Detroit is 4-1-0 against the spread this year.
• The Lions have been underdogs by 2.5 points or more once this year and covered the spread.
• Games involving Detroit have hit the over on three occasions this season.
• The Lions have split the two games they've played as underdogs this season.
• The moneyline for this contest implies a 45.5% chance of a victory for the Lions.

Lions Stats

Detroit's Key Players

Offense

• Jared Goff has thrown for 1,187 yards this year, with 12 touchdowns (first in the NFL) and two interceptions. He is completing 75.2% of his passes while averaging 237.4 yards per game and 8.2 per attempt.
• Amon-Ra St. Brown has 407 receiving yards (fifth in the NFL) and six touchdowns (first in the NFL) on 35 receptions (fifth in the NFL), while being targeted 41 times.
• Jahmyr Gibbs is averaging 65 rushing yards per game this season (325 total yards), while scoring four rushing touchdowns.
• In addition to his rushing stats, Gibbs has grabbed 22 passes (on 23 targets) for 112 yards (fourth on the Lions), with one receiving touchdown. He averages 22.4 yards per game.
• David Montgomery averages 62 rushing yards per game over five games (310 total yards), with four rushing touchdowns.

Defense

• Jack Campbell has 46 tackles, three TFL, and one sack in 2025.
• Aidan Hutchinson has 12 tackles, five TFL, and five sacks.
• Brian Branch has 26 tackles, four TFL, and one sack in the 2025 season. He is third on the Lions in tackles.
• Derrick Barnes' season stats include 31 tackles, two TFL, and two sacks through five games. He is second on the Lions in tackles.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Kansas City Chiefs

Detroit Lions