Chiefs vs. Jaguars 2025 Prediction, Odds, Picks - Oct 6

The Kansas City Chiefs (2-2) are favored by 3.5 points against the Jacksonville Jaguars (3-1) on October 6, 2025, starting at 8:15 p.m. ET, airing on ABC/ESPN. The expected point total for the matchup is 45.5.

Keep up with the 2025 NFL season on FOX Sports.

Chiefs vs. Jaguars Odds & Betting Lines

Chiefs vs. Jaguars Prediction & Pick

• Pick ATS: Jaguars (+3.5)
  
• Pick OU: Under (45.5)
  
• Prediction: Jaguars 25 - Chiefs 17

How to Watch Kansas City vs. Jacksonville

• Game date: Monday, October 6, 2025
• Time: 8:15 p.m. ET
• Venue: EverBank Stadium
• Location: Jacksonville, Florida
• TV: ABC/ESPN
• Live Boxscore: FOX Sports

Chiefs vs. Jaguars Recent Matchups

• In their last five head-to-head meetings, Kansas City has taken down Jacksonville five times.
• In their last five head-to-head matchups, Kansas City has scored 141 points versus Jacksonville, while allowing only 86 points.

Kansas City Betting Info

• Kansas City has two wins versus the spread in four games this season.
• The Chiefs have covered the spread once when favored by 3.5 points or more this season (in two opportunities).
• Kansas City games this year have gone over the total in two out of four opportunities (50%).
• The Chiefs have been moneyline favorites in two other games this season, and they split them.
• The Chiefs have an implied win probability, based on the moneyline, of 66.4%.

Chiefs Stats

Kansas City's Key Players

Offense

• Patrick Mahomes has 939 passing yards through four games this year, averaging 234.8 per game with a 61.3% completion percentage and seven touchdowns against one interception.
• He has added 130 rushing yards (32.5 per game) and two touchdowns on the ground.
• Tyquan Thornton's 182 receiving yards this season have come from 20 targets and 10 receptions. He's averaging 45.5 receiving yards and 2.5 catches per game, with three receiving touchdowns.
• Marquise Brown has one touchdown catch this season, and has 22 receptions for 209 yards on 32 targets, while averaging 5.5 catches and 52.3 yards per game.
• Travis Kelce has 15 receptions for 182 yards and one touchdown. He's been targeted 22 times in the passing game, and averages 3.8 receptions and 45.5 yards through four games played.

Defense

• On defense, George Karlaftis III has three sacks (first on the Chiefs) to go with six TFL and 18 tackles in 2025.
• Drue Tranquill has 24 tackles, two TFL, and two sacks.
• Nick Bolton has recorded 34 tackles and two TFL this year.
• Chamarri Conner has 27 tackles on the year.

Jacksonville Betting Info

• Jacksonville is 3-1-0 against the spread this year.
• The Jaguars have covered the spread once this season when underdogs by 3.5 points or more (in two chances).
• Jacksonville games have gone over the total twice this year.
• The Jaguars have split the two games they've played as underdogs this season.
• Oddsmakers have implied with the moneyline set for this matchup that the Jaguars have a 37.9% chance to win.

Jaguars Stats

Jacksonville's Key Players

Offense

• Travis Etienne has rushed for two touchdowns this year, and has racked up 394 total rushing yards (98.5 per game and 6.1 per carry).
• On top of his rushing statistics, Etienne has caught six passes (on 10 targets) for 32 yards (eighth on the Jaguars), with one receiving touchdown. He's averaging 8 yards per game.
• In four games, Trevor Lawrence has 845 passing yards, while throwing five touchdowns against four interceptions and completing 58.3% of his passes.
• Bhayshul Tuten is averaging 22 rushing yards per game this season (88 total yards), while scoring one rushing touchdown.
• Tuten has helped in the passing attack, putting up 40 receiving yards (10 per game) on three catches (0.8 per game), while being targeted four times. He has one receiving touchdown.
• Brian Thomas has 164 receiving yards from 12 receptions after receiving 32 targets.

Defense

• Foyesade Oluokun has intercepted one pass and also has 30 tackles, two TFL, one sack, and two passes defended in 2025.
• Devin Lloyd's stat sheet includes three interceptions (first in the NFL) as well as 17 tackles, two TFL, and three passes defended.
• Jourdan Lewis has intercepted two passes on top of 19 tackles, three TFL, and six passes defended in the 2025 campaign. His interception total ranks fifth in the league.
• Tyson Campbell has one TFL and 27 tackles over four games.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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