Chargers vs. Vikings 2025 Prediction, Odds, Picks - Oct 23

The Los Angeles Chargers (4-3) are considered favorites (-3.5) according to the oddsmakers ahead of their game versus the Minnesota Vikings (3-3) on October 23, 2025, starting at 8:15 p.m. ET, airing on Amazon Prime Video. An over/under of 44.5 points has been set for the matchup.

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Chargers vs. Vikings Odds & Betting Lines

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Chargers vs. Vikings Prediction & Pick

• Pick ATS: Vikings (+3.5)
  
• Pick OU: Over (44.5)
  
• Prediction: Chargers 23 - Vikings 22

How to Watch Los Angeles vs. Minnesota

• Game date: Thursday, October 23, 2025
• Time: 8:15 p.m. ET
• Venue: SoFi Stadium
• Location: Inglewood, California
• TV: Amazon Prime Video
• Live Boxscore: FOX Sports

Chargers vs. Vikings Recent Matchups

• Over their last three meetings, Minnesota has totaled two wins versus Los Angeles.
• In their last three head-to-head matchups, Minnesota has tallied 90 points against Los Angeles, while giving up only 58 points.

Los Angeles Betting Info

• Los Angeles has three wins in seven games versus the spread this season.
• The Chargers have covered the spread once when favored by 3.5 points or more this season (in three opportunities).
• Los Angeles contests this year have gone over the point total 42.9% of the time (three times in seven games with a set point total).
• When playing as the moneyline favorite, the Chargers have won 50% of the time (3-3).
• The Chargers have a 63.0% chance to win this game, based on the implied probability of the moneyline.

Chargers Stats

Los Angeles' Key Players

Offense

• Justin Herbert ranks first in the NFL with 1,913 passing yards in seven games this year, averaging 273.3 per game with a 67.5% completion percentage and 13 touchdowns (sixth in the NFL) against six interceptions.
• He has also rushed for 186 yards (second on the Chargers) without scoring a touchdown on the ground, while averaging 26.6 rushing yards per game.
• Quentin Johnston has caught 28 passes on 47 targets for 407 total yards and five touchdowns. He is averaging 4.7 catches and 67.8 yards per game through six games.
• Through seven games played, Keenan Allen is averaging 62.1 yards and 6.3 receptions per game to total 435 receiving yards and 44 catches (eighth in the NFL). He's been targeted 65 times, and has four receiving touchdowns.
• Ladd McConkey averages 5.3 receptions and 54.3 yards per game, and has 380 total receiving yards and 37 catches. He's gotten 58 total targets, and has caught two touchdown passes.

Defense

• On defense, Derwin James has one interception to go with 49 tackles, five TFL, 1.5 sacks, and three passes defended in 2025.
• Tuli Tuipulotu has 19 tackles, seven TFL, and five sacks this season.
• Daiyan Henley has put up 48 tackles, three TFL, two sacks, and one interception this year.
• Troy Dye has 38 tackles, four TFL, and one sack.

Minnesota Betting Info

• Minnesota has compiled a 3-3-0 record against the spread this season.
• Games involving Minnesota have hit the over on five occasions this season.
• The Vikings lost the only game they've played as the underdog this season.
• The oddsmakers' moneyline implies a 41.3% chance of a victory for the Vikings.

Vikings Stats

Minnesota's Key Players

Offense

• Jordan Mason averages 63.3 rushing yards per game this year (380 total yards), while scoring four rushing touchdowns.
• In four games, Carson Wentz has 1,072 passing yards, with five touchdowns against four interceptions and completing 66.9% of his passes.
• Wentz also has 57 rushing yards (second on the Vikings).
• Through six games played this season, Justin Jefferson has 34 catches (5.7 receptions per game on 8.7 targets per game) for 528 yards (sixth in the NFL) and one receiving touchdown.
• Jordan Addison has 18 catches for 283 yards and one receiving touchdown. He averages six yards per game through three games and has been targeted 26 times.

Defense

• Eric Wilson's 2025 effort includes 39 tackles, three TFL, and 1.5 sacks in six games. He leads the Vikings in tackles.
• Ivan Pace has totaled one sack in addition to his two TFL and 31 tackles through five games.
• In the 2025 season, Josh Metellus has 35 tackles, one TFL, 0.5 sacks, and one interception in six games.
• Jonathan Greenard's stats include 18 tackles, six TFL, one sack, and two passes defended in six games

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Los Angeles Chargers

Minnesota Vikings