Chargers vs. Raiders 2025 Prediction, Odds, Picks - Sep 15

The Los Angeles Chargers (1-0) are the favorites -- expected to win by at least a field goal, but less than a touchdown (currently -3.5) -- against the Las Vegas Raiders (1-0) in a battle of two division rivals. The over/under for this one is set at 46.5 points.

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Chargers vs. Raiders Odds & Betting Lines

Chargers vs. Raiders Prediction & Pick

• Pick ATS: Chargers (-3.5)
  
• Pick OU: Under (46.5)
  
• Prediction: Chargers 26 - Raiders 17

How to Watch Los Angeles vs. Las Vegas

• Game date: Monday, September 15, 2025
• Time: 10 p.m. ET
• Venue: Allegiant Stadium
• Location: Paradise, Nevada
• TV: ESPN
• Live Boxscore: FOX Sports

Chargers vs. Raiders Recent Matchups

• Over their last five meetings, Los Angeles has put up three wins against Las Vegas.
• Over their last five head-to-head matchups, Las Vegas has put up 137 points, while Los Angeles has posted 121.

Los Angeles Betting Info

• Los Angeles compiled a 13-4-0 ATS record last year.
• Against the spread, as 3.5-point favorites or greater, the Chargers went 5-0 last year.
• Last season, eight Los Angeles games hit the over.
• The Chargers won 84.6% of the games last season when they were the moneyline favorite (11-2).
• Los Angeles won all five games it played as a moneyline favorite with odds of -192 or shorter.
• Based on this game's moneyline, the Chargers' implied win probability is 65.8%.

Chargers Stats (2024)

Los Angeles' Key Players

Offense

• In 17 games played last year, Justin Herbert amassed 3,870 passing yards (ninth-best in the NFL), with 23 touchdowns against three interceptions and completing 65.9% of his attempts.
• Herbert also rushed for two touchdowns and 306 yards.
• Najee Harris had 1,043 rushing yards for the Steelers and six rushing touchdowns, while averaging 61.4 yards per game and 4 per carry (35th in the NFL).
• Harris also picked up 283 receiving yards (16.6 per game) on 36 catches (2.1 per game). He was targeted 48 times and is still seeking his first receiving touchdown.
• Ladd McConkey recorded 1,149 receiving yards (10th in the NFL) and seven touchdowns on 82 receptions while being targeted 112 times last year.
• Quentin Johnston had 55 catches for 711 yards and eight receiving touchdowns. He averaged 3.7 yards per game over 15 games and was targeted 91 times.

Defense

• In 2024, Daiyan Henley recorded one sack to go with seven TFL, 142 tackles, and one interception over 16 games.
• Derwin James had 93 tackles, 10 TFL, 5.5 sacks, and one interception.
• During the 2024 campaign, Tuli Tuipulotu had 38 tackles, 11 TFL, and 8.5 sacks over 15 games.
• Khalil Mack totaled six sacks to go with six TFL and 39 tackles over 15 games.

Las Vegas Betting Info

• Las Vegas covered seven times in 17 games with a spread last year.
• As 3.5-point underdogs or greater, the Raiders went 4-6-1 against the spread last year.
• Las Vegas games hit the over nine out of 17 times last season.
• Last season, the Raiders were the underdog 14 times and won two of those games.
• Last season, Las Vegas won one of its 10 games, or 10%, when it was the underdog by at least +160 on the moneyline.
• The sportsbooks' moneyline implies a 38.5% chance of a victory for the Raiders.

Raiders Stats (2024)

Las Vegas' Key Players

Offense

• For the Seahawks, Geno Smith averaged 7.5 passing yards per attempt (12th in NFL) and 254.1 yards per game last season, completing 70.4% of his passes for 4,320 total yards (fourth in NFL) and 21 TDs with 15 INTs in 17 games.
• Smith also ran for two TDs and 272 yards.
• Brock Bowers had 112 receptions (third in the NFL) for 1,194 yards (eighth in the NFL) and five receiving TDs. He was targeted 153 times and averaged 6.6 catches in 17 games.
• Jakobi Meyers put up 1,027 yards receiving and four TDs on 87 receptions while being targeted 129 times last year.
• Tre Tucker was targeted 81 times, resulting in 47 receptions for 539 yards.

Defense

• Germaine Pratt picked off two passes in addition to 143 tackles, five TFL, and six passes defended for the Bengals in 2024.
• Jeremy Chinn's production for the Commanders included one INT as well as 107 tackles, seven TFL, two sacks, and five passes defended.
• Maxx Crosby had 45 tackles, 17 TFL, 7.5 sacks, and five passes defended in 2024.
• Isaiah Pola-Mao's stats for the year included 85 tackles, two TFL, and one sack in 16 games.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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