49ers vs. Browns 2025 Prediction, Odds, Picks - Nov 30

The San Francisco 49ers (8-4) are favored by 5.5 points versus the Cleveland Browns (3-8) on November 30, 2025, starting at 1 p.m. ET, airing on CBS. The predicted point total for the matchup is 35.5.

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49ers vs. Browns Odds & Betting Lines

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49ers vs. Browns Prediction & Pick

• Pick ATS: 49ers (-5.5)
  
• Pick OU: Over (35.5)
  
• Prediction: 49ers 27 - Browns 15

How to Watch San Francisco vs. Cleveland

• Game date: Sunday, November 30, 2025
• Time: 1 p.m. ET
• Venue: Huntington Bank Field
• Location: Cleveland, Ohio
• TV: CBS
• Live Boxscore: FOX Sports

49ers vs. Browns Recent Matchups

• In their past two matchups, Cleveland has a split 1-1 record against San Francisco.
• Cleveland has been outpaced by 26 points in its last two tilts against San Francisco.

San Francisco Betting Info

• San Francisco has seven wins in 12 games versus the spread this season.
• The 49ers have been favored by 5.5 points or more once this season, and covered the spread.
• San Francisco games this year have gone over the total in seven out of 12 opportunities (58.3%).
• When playing as the moneyline favorite, the 49ers are 7-1 (winning 87.5% of the time).
• The implied probability for this matchup, considering the moneyline, gives the 49ers a 71.4% chance to win.

49ers Stats

San Francisco's Key Players

Offense

• Christian McCaffrey has racked up 796 rushing yards (10th in the NFL) with seven touchdowns (66.3 yards per game across 12 games). His 3.7 yards per attempt rank 38th in the NFL.
• McCaffrey has been targeted 103 times in the receiving game and has 81 catches (6.8 per game) for 785 yards (65.4 per game) and five TDs.
• Mac Jones has 2,151 passing yards, 13 touchdowns and six interceptions this year. He has completed 69.6% of his passes, averaging 239 yards per game and 7.4 per attempt.
• In the passing game, Jauan Jennings, has contributed with 419 receiving yards and four touchdowns after hauling in 37 balls on 63 targets. Per game, he's averaging 41.9 yards and 3.7 receptions through 10 games.
• George Kittle has racked up 329 receiving yards and five touchdowns with 33 catches on 40 targets. He is averaging 4.7 receptions and 47 yards per game.

Defense

• On the defensive side for the 49ers, Dee Winters has powered the unit with 78 tackles and six TFL in 2025.
• Upton Stout has 57 tackles, three TFL, and one sack this season.
• Bryce Huff has collected 21 tackles, six TFL, and four sacks this year.
• So far this season, Deommodore Lenoir has 43 tackles, three TFL, and two interceptions.

Cleveland Betting Info

• Cleveland has covered the spread five times over 11 games with a set total.
• This year, the Browns have just two ATS wins in six games as an underdog of 5.5 points or more.
• Cleveland's games have finished with a final combined score above the over/under six times this season.
• This season, the Browns have been the underdog nine times and won two of those games.
• The Browns have a 32.8% chance to win this game based on the implied probability of the moneyline.

Browns Stats

Cleveland's Key Players

Offense

• Quinshon Judkins has rushed for seven touchdowns this year, and has put up 667 total rushing yards (66.7 per game and 3.9 per attempt).
• Through eight games, Dillon Gabriel has 937 passing yards, while throwing seven touchdowns against two interceptions and completing 59.2% of his attempts.
• Gabriel also has 86 rushing yards (third on the Browns).
• Harold Fannin has put up 462 receiving yards and two touchdowns on 48 receptions, while being targeted 69 times this season.
• David Njoku has 30 catches for 288 yards and three receiving touchdowns. He averages 3.3 yards per game through nine games and has been targeted 45 times.

Defense

• In 2025, Myles Garrett has put up 44 tackles, 26 TFL, and 18 sacks through 11 games.
• Carson Schwesinger has 88 tackles, nine TFL, 1.5 sacks, and two interceptions. He leads the Browns in tackles.
• Devin Bush Jr. has 74 tackles, six TFL, two sacks, and one interception in the 2025 campaign. He is second on the Browns in tackles.
• Tyson Campbell has one TFL, 64 tackles, and one interception over 11 games.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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