2025 NFL Week 5 Predictions, Betting Odds & TV Schedule

The San Francisco 49ers versus the Los Angeles Rams is one of many strong options on the Week 5 NFL slate.

With Week 5 in the NFL upon us, stay on top of the latest betting odds with our preview below.

Check out the full NFL schedule on FOX Sports!

Week 5 Betting Lines & Game Info

Los Angeles Rams vs. San Francisco 49ers

Odds & Prediction

• Spread: Rams (-8.5)
• Moneyline: Rams -452, 49ers +350
• Total: 43.5 points
• Prediction: Rams 23, 49ers 19

How to Watch

• Game Date: Thursday, Oct. 2
• Game Time: 8:15 p.m. ET
• TV Channel: Amazon Prime Video
• Box Score
• Location: Inglewood, California

Cleveland Browns vs. Minnesota Vikings

Odds & Prediction

• Spread: Vikings (-3.5)
• Moneyline: Vikings -195, Browns +161
• Total: 35.5 points
• Prediction: Vikings 27, Browns 16

How to Watch

• Game Date: Sunday, Oct. 5
• Game Time: 9:30 a.m. ET
• TV Channel: NFL Network
• Box Score
• Location: London, England

New York Jets vs. Dallas Cowboys

Odds & Prediction

• Spread: Jets (-1.5)
• Moneyline: Jets -121, Cowboys +101
• Total: 47.5 points
• Prediction: Cowboys 29, Jets 28

How to Watch

• Game Date: Sunday, Oct. 5
• Game Time: 1 p.m. ET
• TV Channel: FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
• Location: East Rutherford, New Jersey

Indianapolis Colts vs. Las Vegas Raiders

Odds & Prediction

• Spread: Colts (-7)
• Moneyline: Colts -369, Raiders +286
• Total: 47.5 points
• Prediction: Colts 33, Raiders 15

How to Watch

• Game Date: Sunday, Oct. 5
• Game Time: 1 p.m. ET
• TV Channel: FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
• Location: Indianapolis, Indiana

New Orleans Saints vs. New York Giants

Odds & Prediction

• Spread: Saints (-1.5)
• Moneyline: Saints -126, Giants +106
• Total: 42.5 points
• Prediction: Giants 23, Saints 22

How to Watch

• Game Date: Sunday, Oct. 5
• Game Time: 1 p.m. ET
• TV Channel: CBS
• Box Score
• Location: New Orleans, Louisiana

Carolina Panthers vs. Miami Dolphins

Odds & Prediction

• Spread: Dolphins (-1.5)
• Moneyline: Dolphins -119, Panthers -101
• Total: 44.5 points
• Prediction: Panthers 27, Dolphins 20

How to Watch

• Game Date: Sunday, Oct. 5
• Game Time: 1 p.m. ET
• TV Channel: FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
• Location: Charlotte, North Carolina

Baltimore Ravens vs. Houston Texans

Odds & Prediction

• Spread: Texans (-2.5)
• Moneyline: Texans -145, Ravens +121
• Total: 41.5 points
• Prediction: Ravens 25, Texans 22

How to Watch

• Game Date: Sunday, Oct. 5
• Game Time: 1 p.m. ET
• TV Channel: CBS
• Box Score
• Location: Baltimore, Maryland

Philadelphia Eagles vs. Denver Broncos

Odds & Prediction

• Spread: Eagles (-4.5)
• Moneyline: Eagles -222, Broncos +184
• Total: 44.5 points
• Prediction: Eagles 29, Broncos 16

How to Watch

• Game Date: Sunday, Oct. 5
• Game Time: 1 p.m. ET
• TV Channel: CBS
• Box Score
• Location: Philadelphia, Pennsylvania

Arizona Cardinals vs. Tennessee Titans

Odds & Prediction

• Spread: Cardinals (-7.5)
• Moneyline: Cardinals -427, Titans +331
• Total: 41.5 points
• Prediction: Cardinals 29, Titans 12

How to Watch

• Game Date: Sunday, Oct. 5
• Game Time: 4:05 p.m. ET
• TV Channel: CBS
• Box Score
• Location: Glendale, Arizona

Seattle Seahawks vs. Tampa Bay Buccaneers

Odds & Prediction

• Spread: Seahawks (-3.5)
• Moneyline: Seahawks -192, Buccaneers +159
• Total: 44.5 points
• Prediction: Seahawks 30, Buccaneers 17

How to Watch

• Game Date: Sunday, Oct. 5
• Game Time: 4:05 p.m. ET
• TV Channel: CBS
• Box Score
• Location: Seattle, Washington

Los Angeles Chargers vs. Washington Commanders

Odds & Prediction

• Spread: Chargers (-3)
• Moneyline: Chargers -162, Commanders +138
• Total: 47.5 points
• Prediction: Chargers 26, Commanders 18

How to Watch

• Game Date: Sunday, Oct. 5
• Game Time: 4:25 p.m. ET
• TV Channel: FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
• Location: Inglewood, California

Cincinnati Bengals vs. Detroit Lions

Odds & Prediction

• Spread: Lions (-9.5)
• Moneyline: Lions -592, Bengals +426
• Total: 49.5 points
• Prediction: Lions 30, Bengals 21

How to Watch

• Game Date: Sunday, Oct. 5
• Game Time: 4:25 p.m. ET
• TV Channel: FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
• Location: Cincinnati, Ohio

Buffalo Bills vs. New England Patriots

Odds & Prediction

• Spread: Bills (-7.5)
• Moneyline: Bills -442, Patriots +344
• Total: 49 points
• Prediction: Bills 29, Patriots 22

How to Watch

• Game Date: Sunday, Oct. 5
• Game Time: 8:20 p.m. ET
• TV Channel: NBC
• Box Score
• Location: Orchard Park, New York

Jacksonville Jaguars vs. Kansas City Chiefs

Odds & Prediction

• Spread: Chiefs (-3.5)
• Moneyline: Chiefs -199, Jaguars +165
• Total: 45.5 points
• Prediction: Jaguars 25, Chiefs 17

How to Watch

• Game Date: Monday, Oct. 6
• Game Time: 8:15 p.m. ET
• TV Channel: ABC/ESPN
• Box Score
• Location: Jacksonville, Florida

Learn more about today's games on FOX Sports.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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