2025 NFL Week 16 Injury Report: Latest injuries for every team

Updated Dec. 22, 2025 3:26 p.m. ET

Data Skrive

Every NFL team has to deal with injuries, and the complete list is provided here as we look ahead to the Week 16 NFL slate of games, with many important players possibly being out.

The article below will be updated with the latest practice and game status for each game as teams provide new information, so be sure to come back to discover who's in and who's out.

Keep up with the 2025 NFL season on FOX Sports.

Week 16 Injury Reports

Prior to the final injury report, which lists players as questionable, doubtful or out, NFL teams use practice designations to update player injury statuses. This can include DNP (did not participate), LP (limited participant) or FP (full participant).

Colts vs. 49ers Injury Report

8:15 p.m. ET on Monday

Colts Injuries: Ameer Abdullah, RB: FP (Knee), DeForest Buckner, DT: DNP (Neck), Josh Downs, WR: FP (Personal), Samson Ebukam, DE: LP (NIR - Rest), Johnathan Edwards, CB: FP (Illness), Zaire Franklin, LB: DNP (NIR - Rest), Sauce Gardner, CB: out (Calf), Anthony Gould, WR: out (Foot), Tyquan Lewis, DE: FP (Chest), Quenton Nelson, OG: FP (Wrist), Alec Pierce, WR: FP (Achilles), Germaine Pratt, LB: FP (Personal), Bernhard Raimann, OT: out (Elbow), Anthony Richardson, QB: out (Eye), Daniel Scott, S: out (Knee), Grover Stewart, DT: FP (Rest)

49ers Injuries: Tatum Bethune, LB: FP (Ankle), Spencer Burford, OL: FP (Knee), Jordan Elliott, DL: FP (Knee), Renardo Green, CB: out (Neck), Yetur Gross-Matos, DL: questionable (Hamstring), Nickolas Martin, LB: DNP (Concussion), Christian McCaffrey, RB: FP (NIR - Rest), Sam Okuayinonu, DL: FP (Ankle), Ricky Pearsall, WR: out (Knee), Kurtis Rourke, QB: out (Knee), Trent Williams, OT: FP (NIR - Rest), Dee Winters, LB: FP (Wrist)