Celtics vs. 76ers Prediction, Odds, Picks - Oct. 22

The Philadelphia 76ers begin their 2025-26 NBA season on October 22, 2025, taking on the Boston Celtics at TD Garden. Wednesday's game between the Celtics and the 76ers sees the Celtics as 4.5-point favorites. The matchup's point total is 229.5.

Here's everything you need to know about the Celtics-76ers game, from the point spread, moneyline, total Over/Under and expert picks, as well as TV channel and streaming information.

Celtics vs. 76ers Game Information, TV Channel & Odds

• When: Wednesday, October 22, 2025 at 7:30 p.m. ET
• Where: TD Garden in Boston, Massachusetts
• TV: NBCS-BOS and NBCS-PH
• Live Boxscore: FOX Sports

Celtics vs. 76ers Prediction

ATS Pick: Celtics (- 4.5)
O/U Pick: Under (229.5)
Score Prediction: Celtics 122 - 76ers 101

Celtics vs. 76ers Betting Insights

• In 29 of 82 games last season, the Celtics and their opponents went over 229.5 points.
• The 76ers played 30 games last season that finished with a combined score over 229.5 points.
• The two teams combined to score 225.9 points per contest last season, 3.6 fewer points than this game's point total.
• Combined, these teams surrendered 223 points per contest last year, 6.5 fewer points than the total for this game.
• The Celtics had an average total of 226.3 in their contests last season, 3.2 fewer points than this game's over/under.
• The 76ers had a 222.4-point average over/under in their outings last year, 7.1 fewer points than this game's point total.

Celtics Recent Trends

• Boston compiled a 39-42-1 record against the spread last season.
• Boston was favored by 4.5 points or more 71 times last season, and covered the spread in 34 of those games.
• A total of 37 Boston games last season hit the over.
• Last year, the Celtics put up just 0.5 more points per game (116.3) than the 76ers gave up (115.8).
• Boston had a 30-16 record against the spread and a 41-5 record overall last season when scoring more than 115.8 points.
• Last season, the Celtics had a 46.2% shooting percentage from the field, which was 2.6% lower than the 48.8% of shots the 76ers' opponents made.
• The Celtics covered the spread in a lower percentage of their home games than away games last year. They covered 18 times in 41 games when playing at home, and they covered 21 times in 41 games when playing on the road.
• When it came to point totals, Boston hit the over more often when playing at home last season, as it eclipsed the total 21 times in 41 opportunities (51.2%). On the road, it hit the over 16 times in 41 opportunities (39%).
• The Celtics fared worse as a moneyline favorite at home last season, sporting a home record of 27-13, compared to going 32-6 in away games.

Celtics Recent Stats

Celtics Leaders

• Per game, Jayson Tatum put up points, 8.7 rebounds and 6 assists last season. He also put up 1.1 steals and 0.5 blocks.
• Per game, Derrick White averaged 16.4 points, 4.5 rebounds and 4.8 assists. He also averaged 0.9 steals and 1.1 blocks.
• Jaylen Brown's stats last season included 22.2 points, 5.8 boards and 4.5 assists per contest. He made 46.3% of his shots from the field and 32.4% from 3-point range, with an average of 1.8 treys.
• Anfernee Simons averaged 19.3 points, 2.7 boards and 4.8 assists. He made 42.6% of his shots from the floor and 36.3% from 3-point range, with 3.1 triples per game.
• Payton Pritchard's numbers last season were 14.3 points, 3.8 rebounds and 3.5 assists per contest. He made 47.2% of his shots from the floor and 40.7% from beyond the arc, with an average of 3.2 triples (10th in NBA).

Celtics Player Props

76ers Recent Trends

• The 76ers compiled a 29-53-0 record against the spread last season.
• Philadelphia went 19-21 as an underdog of 4.5 points or more last season.
• 76ers games hit the over 47 out of 82 times last year.
• The 76ers' 109.6 points per game last year were only 2.4 more points than the 107.2 the Celtics gave up.
• Philadelphia put together a 22-23 ATS record and a 22-23 overall record last season in games it scored more than 107.2 points.
• The 76ers shot 45.4% from the field, 0.4% higher than the 45% the Celtics' opponents shot last season.
• In 2024-25 against the spread, the 76ers had a lower winning percentage at home (.293, 12-29-0 record) than on the road (.415, 17-24-0).
• Looking at the over/under, Philadelphia's games went over 21 of 41 times at home (51.2%) and 26 of 41 on the road (63.4%) last season.
• The 76ers, as moneyline favorites, won a lower percentage of games at home (7-10) than on the road (7-5) last year.

76ers Recent Stats

76ers Leaders

• Tyrese Maxey scored 26.3 points per game last season to go with 6.1 assists.
• Kelly Oubre Jr. pulled down 6.1 boards per game while also scoring 15.1 points a contest.
• Quentin Grimes hit an average of 2.2 shots per game from beyond the arc a season ago.
• Oubre averaged 1.5 takeaways per game, while Adem Bona compiled 1.2 rejections per contest.

76ers Player Props

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

FOLLOW Follow your favorites to personalize your FOX Sports experience

National Basketball Association

Boston Celtics

Philadelphia 76ers