Cavaliers vs. Pacers Prediction, Odds, Picks - Nov. 21

The Indiana Pacers (2-13) travel to face the Cleveland Cavaliers (10-6) after dropping eight consecutive road games. Friday's game between the Cavaliers and the Pacers sees the Cavaliers as a double-digit favorite by 13.5 points. The over/under is 239.5 points for the matchup.

Here's everything you need to know about the Cavaliers-Pacers game, from the point spread, moneyline, total Over/Under and expert picks, as well as TV channel and streaming information.

Cavaliers vs. Pacers Game Information, TV Channel & Odds

• When: Friday, November 21, 2025 at 7 p.m. ET
• Where: Rocket Arena in Cleveland, Ohio
• TV: Amazon Prime Video
• Live Boxscore: FOX Sports

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Cavaliers vs. Pacers Prediction

ATS Pick: Cavaliers (- 13.5)
O/U Pick: Under (239.5)
Score Prediction: Cavaliers 126 - Pacers 108

Cavaliers vs. Pacers Betting Insights

• Of 16 games so far this year, the Cavaliers have played six with more than 239.5 points scored, their current matchup's point total.
• The Pacers games have gone over 239.5 total points scored in four of 15 total matchups this year.
• The two teams average a combined 9.5 fewer points per game (230) than this matchup's total of 239.5 points.
• Opponents of these two teams have averaged a combined 239.2 points per game, 0.3 fewer than the point total for this matchup.
• Cleveland has been chosen as the favorite in 14 games this year and has walked away with the win nine times (64.3%) in those games.
• Indiana has come away with two wins in the 13 contests it has been listed as the underdog this season.
• Indiana has taken seven of its last nine head-to-head matchups against Cleveland.
• The Pacers also have a 6-3 record against the spread when taking on the Cavaliers.

Cavaliers Recent Trends

• The Cavaliers are 5-5 against the spread and 7-3 overall over their past 10 games.
• Cleveland and its opponents have combined to score an average of 238.1 points over its last 10 games, 1.4 less than the 239.5 over/under in this matchup.
• The Cavaliers have played 16 games, with six wins against the spread.
• Cleveland covered the spread in its only game when favored by 13.5 points or more.
• The Cavaliers have hit the over in 53.3% of their opportunities this year (eight times over 15 games with a set point total).
• The Cavaliers record only 3.2 fewer points per game (119.9) than the Pacers give up (123.1).
• When Cleveland scores more than 123.1 points, it is 3-3 against the spread and 5-1 overall.
• This season, the Cavaliers have a 45.8% shooting percentage from the field, which is 2.4% lower than the 48.2% of shots the Pacers' opponents have made.
• Against the spread, the Cavaliers have played worse at home, covering three times in nine home games, and three times in seven road games.
• In terms of point totals, Cleveland hits the over less often at home, as it has gone over the total three times in nine opportunities this season (33.3%). On the road, it has hit the over five times in seven opportunities (71.4%).
• The Cavaliers have fared better as a moneyline favorite in home games, putting up a home record of 6-2, compared to going 3-3 away from home.

Cavaliers Recent Stats

Cavaliers Leaders

• Donovan Mitchell averages 30.2 points, 4.5 rebounds and 5.3 assists per contest. Defensively, he averages 1.5 steals and 0.4 blocks.
• Evan Mobley averages 18.8 points, 4.0 assists and 8.6 boards per game.
• Jarrett Allen puts up 14.8 points, 7.6 boards and 1.9 assists per game, shooting 57.7% from the floor.
• De'Andre Hunter averages 18.0 points, 2.8 assists and 4.7 rebounds.
• Craig Porter Jr. averages 6.1 points, 3.1 rebounds and 2.6 assists per contest, shooting 54.2% from the field.

Cavaliers Player Props

Pacers Recent Trends

• The Pacers have a 3-7 record against the spread while finishing 2-8 overall in their past 10 games.
• Indiana's average total over the last 10 games is 7.0 points fewer than the 239.5 total listed for this matchup.
• The Pacers have played 15 games, with six wins against the spread.
• The Pacers have eclipsed the over/under 40% of the time this year (six of 15 games with a set point total).
• The Pacers average 6.0 fewer points per game (110.1) than the Cavaliers allow (116.1).
• Indiana has put together a 2-1 ATS record and a 1-2 overall record in games it scores more than 116.1 points.
• The Pacers have shot at a 41.1% clip from the field this season, 5.1 percentage points fewer than the 46.2% shooting opponents of the Cavaliers have averaged.
• In 2025-26 against the spread, the Pacers have a better winning percentage at home (.571, 4-3-0 record) than away (.250, 2-6-0).
• Looking at the over/under, Indiana's games have gone over four of seven times at home (57.1%), and two of eight away (25%).
• The Pacers, when moneyline favorites, have won the same percentage of games at home (0-1) and on the road (0-1) this year.

Pacers Recent Stats

Pacers Leaders

• On a per-game basis, Pascal Siakam gets the Pacers 24.7 points, 6.9 rebounds and 4.9 assists. He also averages 1.1 steals and 0.4 blocked shots.
• Jarace Walker is putting up 9.9 points, 5.1 rebounds and 2.8 assists per game. He's draining 30.6% of his shots from the field and 28.9% from 3-point range, with 1.5 triples per game.
• Isaiah Jackson gets the Pacers 8.2 points, 6.2 rebounds and 1.1 assists per contest while putting up 0.7 steals and 0.6 blocked shots.
• The Pacers are getting 6.9 points, 4.5 rebounds and 1.8 assists per game from Ben Sheppard this season.
• Jay Huff is averaging 6.4 points, 3.0 rebounds and 0.9 assists per contest. He is making 40.0% of his shots from the floor and 29.3% from 3-point range, with 1.1 treys per game.

Pacers Player Props

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.