Cavaliers vs. Pacers Prediction, Odds, Picks - Nov. 21

The Indiana Pacers (2-13) travel to face the Cleveland Cavaliers (10-6) after dropping eight consecutive road games. Friday's game between the Cavaliers and the Pacers sees the Cavaliers as a double-digit favorite by 13.5 points. The over/under is 239.5 points for the matchup.

Here's everything you need to know about the Cavaliers-Pacers game, from the point spread, moneyline, total Over/Under and expert picks, as well as TV channel and streaming information.

Cavaliers vs. Pacers Game Information, TV Channel & Odds

• When: Friday, November 21, 2025 at 7 p.m. ET
• Where: Rocket Arena in Cleveland, Ohio
• TV: Amazon Prime Video
• Live Boxscore: FOX Sports

This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports.

Cavaliers vs. Pacers Prediction

ATS Pick: Cavaliers (- 13.5)
O/U Pick: Under (239.5)
Score Prediction: Cavaliers 126 - Pacers 108

Cavaliers vs. Pacers Betting Insights

• Of 16 games so far this year, the Cavaliers have played six with more than 239.5 points scored, their current matchup's point total.
• The Pacers games have gone over 239.5 total points scored in four of 15 total matchups this year.
• The two teams average a combined 9.5 fewer points per game (230) than this matchup's total of 239.5 points.
• Opponents of these two teams have averaged a combined 239.2 points per game, 0.3 fewer than the point total for this matchup.
• Cleveland has been chosen as the favorite in 14 games this year and has walked away with the win nine times (64.3%) in those games.
• Indiana has come away with two wins in the 13 contests it has been listed as the underdog this season.
• Indiana has taken seven of its last nine head-to-head matchups against Cleveland.
• The Pacers also have a 6-3 record against the spread when taking on the Cavaliers.

Cavaliers Recent Trends

• The Cavaliers are 5-5 against the spread and 7-3 overall over their past 10 games.
• Cleveland and its opponents have combined to score an average of 238.1 points over its last 10 games, 1.4 less than the 239.5 over/under in this matchup.
• The Cavaliers have played 16 games, with six wins against the spread.
• Cleveland covered the spread in its only game when favored by 13.5 points or more.
• The Cavaliers have hit the over in 53.3% of their opportunities this year (eight times over 15 games with a set point total).
• The Cavaliers record only 3.2 fewer points per game (119.9) than the Pacers give up (123.1).
• When Cleveland scores more than 123.1 points, it is 3-3 against the spread and 5-1 overall.
• This season, the Cavaliers have a 45.8% shooting percentage from the field, which is 2.4% lower than the 48.2% of shots the Pacers' opponents have made.
• Against the spread, the Cavaliers have played worse at home, covering three times in nine home games, and three times in seven road games.
• In terms of point totals, Cleveland hits the over less often at home, as it has gone over the total three times in nine opportunities this season (33.3%). On the road, it has hit the over five times in seven opportunities (71.4%).
• The Cavaliers have fared better as a moneyline favorite in home games, putting up a home record of 6-2, compared to going 3-3 away from home.

Cavaliers Recent Stats

Cavaliers Leaders

• Donovan Mitchell averages 30.2 points, 4.5 rebounds and 5.3 assists per contest. Defensively, he averages 1.5 steals and 0.4 blocks.
• Evan Mobley averages 18.8 points, 4.0 assists and 8.6 boards per game.
• Jarrett Allen puts up 14.8 points, 7.6 boards and 1.9 assists per game, shooting 57.7% from the floor.
• De'Andre Hunter averages 18.0 points, 2.8 assists and 4.7 rebounds.
• Craig Porter Jr. averages 6.1 points, 3.1 rebounds and 2.6 assists per contest, shooting 54.2% from the field.

Cavaliers Player Props

Pacers Recent Trends

• The Pacers have a 3-7 record against the spread while finishing 2-8 overall in their past 10 games.
• Indiana's average total over the last 10 games is 7.0 points fewer than the 239.5 total listed for this matchup.
• The Pacers have played 15 games, with six wins against the spread.
• The Pacers have eclipsed the over/under 40% of the time this year (six of 15 games with a set point total).
• The Pacers average 6.0 fewer points per game (110.1) than the Cavaliers allow (116.1).
• Indiana has put together a 2-1 ATS record and a 1-2 overall record in games it scores more than 116.1 points.
• The Pacers have shot at a 41.1% clip from the field this season, 5.1 percentage points fewer than the 46.2% shooting opponents of the Cavaliers have averaged.
• In 2025-26 against the spread, the Pacers have a better winning percentage at home (.571, 4-3-0 record) than away (.250, 2-6-0).
• Looking at the over/under, Indiana's games have gone over four of seven times at home (57.1%), and two of eight away (25%).
• The Pacers, when moneyline favorites, have won the same percentage of games at home (0-1) and on the road (0-1) this year.

Pacers Recent Stats

Pacers Leaders

• On a per-game basis, Pascal Siakam gets the Pacers 24.7 points, 6.9 rebounds and 4.9 assists. He also averages 1.1 steals and 0.4 blocked shots.
• Jarace Walker is putting up 9.9 points, 5.1 rebounds and 2.8 assists per game. He's draining 30.6% of his shots from the field and 28.9% from 3-point range, with 1.5 triples per game.
• Isaiah Jackson gets the Pacers 8.2 points, 6.2 rebounds and 1.1 assists per contest while putting up 0.7 steals and 0.6 blocked shots.
• The Pacers are getting 6.9 points, 4.5 rebounds and 1.8 assists per game from Ben Sheppard this season.
• Jay Huff is averaging 6.4 points, 3.0 rebounds and 0.9 assists per contest. He is making 40.0% of his shots from the floor and 29.3% from 3-point range, with 1.1 treys per game.

Pacers Player Props

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

FOLLOW Follow your favorites to personalize your FOX Sports experience

National Basketball Association

Cleveland Cavaliers

Indiana Pacers