76ers vs. Cavaliers Prediction, Odds, Picks - Jan. 16

The Cleveland Cavaliers (23-19) will look to Donovan Mitchell (fourth in NBA, 29.7 points per game) going up against Tyrese Maxey (third in league, 30.5) and the Philadelphia 76ers (22-17) on January 16, 2026 at Xfinity Mobile Arena. Friday's matchup between the 76ers and the Cavaliers features the 76ers as small 3-point favorites. A 233.5-point total has been set for the game.

Here is everything you need to know about the 76ers-Cavaliers game, from the point spread, moneyline, total Over/Under and expert picks, as well as TV channel and streaming information.

76ers vs. Cavaliers Game Information, TV Channel & Odds

• When: Friday, January 16, 2026 at 7 p.m. ET
• Where: Xfinity Mobile Arena in Philadelphia, Pennsylvania
• TV: ESPN, NBCS-PH, and FDSOH
• Live Boxscore: FOX Sports

This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports.

76ers vs. Cavaliers Prediction

ATS Pick: Cavaliers (+ 3)
O/U Pick: Over (233.5)
Score Prediction: 76ers 119 - Cavaliers 116

76ers vs. Cavaliers Betting Insights

• This year, the 76ers games have finished over 233.5 points scored, their current matchup's over/under, 17 (out of 39) times.
• The Cavaliers have played in 22 games this year (52.4% of opportunities) in which the teams combined to score more than 233.5 points.
• Between them, these two teams average 3.4 more points per game (236.9) than this matchup's total (233.5).
• Opponents of these two teams have averaged a combined 233.1 points per game, 0.4 fewer than the over/under for this game.
• Philadelphia has won 17, or 68%, of the 25 contests in which it was the favorite this year.
• Cleveland has been victorious in three of the eight contests it has been chosen as an underdog in this season.
• In the last two head-to-head matchups, Cleveland has a 2-0 record against Philadelphia.
• The Cavaliers also have a 2-0 record against the spread when playing the 76ers.

76ers Recent Trends

• The 76ers have a 6-4 record against the spread while finishing 6-4 overall over their last 10 contests.
• Philadelphia's average total over the last 10 games is four points fewer than the 233.5 over/under given for this matchup.
• The 76ers have played 39 games, with 21 wins against the spread.
• Philadelphia has an ATS record of 9-5 in its 14 games when favored by 3 points or more so far this season.
• 76ers games this year have hit the over 50% of the time (21 out of 42 games with a set point total).
• The 76ers score 116.8 points per game, only 0.7 fewer points than the 117.5 the Cavaliers allow.
• When Philadelphia totals more than 117.5 points, it is 11-4 against the spread and 12-3 overall.
• This season, the 76ers have a 45.4% shooting percentage from the field, which is 1.2% lower than the 46.6% of shots the Cavaliers' opponents have knocked down.
• Against the spread, the 76ers have fared worse at home, covering eight times in 20 home games, and 13 times in 19 road games.
• At home, Philadelphia goes over the over/under 55% of the time (11 of 20 games). It has hit the over in 52.6% of games on the road (10 of 19 contests).
• As a moneyline favorite, the 76ers have won a lower percentage of their home games (.615) compared to road games (.750).

76ers Recent Stats

76ers Leaders

• Maxey posts 30.5 points, 6.6 assists and 4.4 rebounds per contest.
• VJ Edgecombe puts up 15.9 points, 5.3 rebounds and 4.3 assists per contest, shooting 42.5% from the field and 37.6% from downtown with 2.3 made treys per game.
• Quentin Grimes posts 14 points, 3.9 rebounds and 3.8 assists per game, shooting 43.9% from the field and 36.2% from downtown with 2.2 made treys per game.
• Joel Embiid averages 23.5 points, 3.3 assists and 7 rebounds.
• Andre Drummond averages 7 points, 8.8 rebounds and 0.8 assists per game, shooting 50.3% from the field.

76ers Player Props

Cavaliers Recent Trends

• The Cavaliers have gone 6-4 over their past 10 contests, with a 4-6 record against the spread during that span.
• Cleveland and its opponents have combined to score an average of 239 combined points in its last 10 games, 5.5 more than the 233.5 over/under in this matchup.
• In the Cavaliers' 42 games this year, they have 15 wins against the spread.
• So far this year, Cleveland has been installed as underdogs by a 3-point margin or more four times and are 3-1 ATS in those games.
• Cavaliers games this year have eclipsed the over/under 47.6% of the time (20 out of 42 games with a set point total).
• The Cavaliers' 120.1 points per game are just 4.5 more points than the 115.6 the 76ers give up to opponents.
• When it scores more than 115.6 points, Cleveland is 14-11 against the spread and 20-5 overall.
• The Cavaliers' 47.2% shooting percentage from the field this season is 0.8 percentage points higher than the 76ers have given up to their opponents (46.4%).
• In 2025-26 against the spread, the Cavaliers have a lower winning percentage at home (.333, 8-16-0 record) than on the road (.389, 7-11-0).
• In 2025-26 a lower percentage of Cleveland's games have finished above the over/under at home (37.5%, nine of 24) compared to away (61.1%, 11 of 18).
• The Cavaliers' winning percentage at home when moneyline favorites is .609 (14-9), and on the road it is .545 (6-5).

Cavaliers Recent Stats

Cavaliers Leaders

• Mitchell puts up 29.7 points, 4.7 rebounds and 5.6 assists per game for the Cavaliers.
• Evan Mobley is averaging 17.9 points, 8.7 rebounds and 4.1 assists per contest. He's sinking 51.7% of his shots from the field and 33.3% from beyond the arc, with 1.3 treys per game.
• Jaylon Tyson is averaging 12.8 points, 5.3 rebounds and 2 assists per game. He is making 51.3% of his shots from the field and 45.8% from beyond the arc (fifth in league), with 1.9 triples per game.
• Jarrett Allen is putting up 13.5 points, 7.9 rebounds and 2.2 assists per game. He is making 59.6% of his shots from the floor (ninth in league).
• De'Andre Hunter gets the Cavaliers 14 points, 4.3 rebounds and 2.2 assists per contest while putting up 0.6 steals and 0.1 blocked shots.

Cavaliers Player Props

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.