Twins vs. Guardians Prediction, Odds, Picks - April 30

Byron Buxton and the Minnesota Twins will try to outdo Kyle Manzardo and the Cleveland Guardians at Progressive Field on Wednesday at 6:10 p.m. ET. The Twins have been listed as -114 moneyline favorites in this matchup against the Guardians (-105). Minnesota is the run-line favorite (-1.5). The over/under is 7 runs for the game (with -117 odds to hit the over and -103 odds on the under).

Here's everything you need to know from a betting perspective on the Twins-Guardians game, regarding the run line, moneyline and total, plus expert picks.

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Twins vs. Guardians Highlights | MLB on FOX

Check out the top moments from this MLB game between the Minnesota Twins and the Cleveland Guardians!

Twins vs. Guardians Game Information & Odds

• When: Wednesday, April 30, 2025 at 6:10 p.m. ET
• Where: Progressive Field in Cleveland, Ohio
• How to watch on TV: CLEG and MNNT

Twins vs. Guardians Prediction

• Score Prediction: Twins 6, Guardians 5
• Total Prediction: Over 7 runs
• Win Probabilities: Twins 50%, Guardians 50%

Twins vs. Guardians Betting Insights

• The Twins have entered the game as favorites 21 times this season and won 11, or 52.4%, of those games.
• Minnesota has entered 18 games this season favored by -114 or more and is 10-8 in those contests.
• Oddsmakers have implied with the moneyline set for this matchup that the Twins have a 53.3% chance to win.
• The Guardians have been underdogs in 17 games this season and have come away with the win seven times (41.2%) in those contests.
• This season, Cleveland has come away with a win seven times in 17 chances when named as an underdog of at least -105 or worse on the moneyline.
• The Guardians have an implied victory probability of 51.2% according to the moneyline set by sportsbooks for this matchup.

Twins Recent Betting Performance

• The Twins were the moneyline favorite in six of their last 10 games, and they finished 5-1 in those matchups.
• In their last 10 matchups (all 10 of them had set totals), the Twins and their opponents combined to hit the over three times.
• The Twins have an 8-2-0 record against the spread over their past 10 games.

Twins Recent Stats

Twins Player Insights

• Ty France leads the Twins with 18 runs batted in while accumulating a team-best batting average of .267.
• France ranks 103rd in homers and 30th in RBI among all hitters in MLB.
• France takes a hitting streak of four games into this game. In his last five games he is hitting .421 with three doubles, a home run, a walk and six RBI.
• Buxton has hit six home runs to pace his team.
• Among all major league hitters, Buxton ranks 30th in homers and 37th in RBI.
• Trevor Larnach is hitting .223 with two doubles, four home runs and 13 walks.
• Ryan Jeffers is batting .257 with seven doubles, a home run and nine walks.
• Jeffers has recorded at least one hit in three games in a row. During his last five outings he is hitting .350 with three doubles, a home run, three walks and five RBI.

Twins Team Props

Guardians Recent Betting Performance

• The Guardians have played as underdogs in seven of their past 10 games and won four of those contests.
• In their last 10 games with a total, the Guardians and their opponents are 6-4-0 when it comes to hitting the over.
• The Guardians have four wins against the spread in their last 10 chances.

Guardians Recent Stats

Guardians Player Insights

• Steven Kwan leads the team in batting average with a high-water mark of .333.
• In all of the big leagues, Kwan is 67th in homers and 58th in RBI.
• Jose Ramirez is hitting .255 with four doubles, five home runs and nine walks.
• Ramirez ranks 47th in home runs and 72nd in RBI among all MLB hitters this year.
• Manzardo paces the Guardians in home runs (eight) and runs batted in (19).
• Gabriel Arias is batting .270 with six doubles, four home runs and five walks.

Guardians Team Props

Twins vs. Guardians Highlights | MLB on FOX

Check out the top moments from this MLB game between the Minnesota Twins and the Cleveland Guardians!

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Cleveland Guardians

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