Tigers vs. Guardians Prediction, Odds, Picks - September 23

Riley Greene and Steven Kwan will be among the star attractions when the Detroit Tigers face the Cleveland Guardians on Tuesday at 6:40 p.m. ET, at Progressive Field. The Tigers are the favorite in this one, at -163, while the underdog Guardians have +137 odds to win. Detroit is a 1.5-run favorite (at +117 odds). The total for the game is set at 6.5 runs.

Here is everything you need from a betting perspective on the Tigers-Guardians game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

Braves vs. Tigers Highlights | MLB on FOX

Check out the best moments between the Atlanta Braves and Detroit Tigers.

Tigers vs. Guardians Game Information & Odds

• When: Tuesday, September 23, 2025 at 6:40 p.m. ET
• Where: Progressive Field in Cleveland, Ohio
• How to watch on TV: CLEG and FDSDET

Tigers vs. Guardians Prediction

• Score Prediction: Guardians 5, Tigers 4
• Total Prediction: Over 6.5 runs
• Win Probabilities: Tigers 52%, Guardians 48%

Tigers vs. Guardians Betting Insights

• The Tigers have entered the game as favorites 110 times this season and won 63, or 57.3%, of those games.
• Detroit has a record of 32-16, a 66.7% win rate, when favored by -163 or more by sportsbooks this season.
• The moneyline for this contest implies a 62% chance of a victory for the Tigers.
• The Guardians have been victorious in 41, or 47.7%, of the 86 contests they have been chosen as underdogs in this season.
• Cleveland has a win-loss record of 9-15 when favored by +137 or worse by oddsmakers this year.
• The moneyline set for this matchup implies the Guardians have a 42.2% chance of walking away with the win.

Tigers Recent Betting Performance

• The Tigers have a 1-8 record from the nine games they were moneyline favorites over their last 10 matchups.
• In their last 10 outings (all had set totals), the Tigers combined with their opponents to hit the over on the total six times.
• The Tigers' ATS record is 1-9-0 over their past 10 games.

Tigers Recent Stats

Tigers Player Insights

• Gleyber Torres' .261 average leads the Tigers this year. His resume also includes 16 homers and driven in 74 RBI.
• Torres is 122nd in homers and 65th in RBI among all hitters in MLB.
• Torres carries a four-game hitting streak into this matchup. During his last five outings he is batting .444 with a double, three walks and an RBI.
• Greene has put his power on display as he leads his team with 34 home runs and 109 runs batted in.
• Greene ranks 10th in home runs in MLB, and fifth in RBI.
• Spencer Torkelson is batting .243 with 27 doubles, a triple, 31 home runs and 69 walks.
• Zach McKinstry has 22 doubles, 11 triples, 12 home runs and 46 walks while batting .260.
• McKinstry brings a two-game streak with at least one hit into this one. During his last five outings he is hitting .231 with a double, a home run, a walk and an RBI.

Tigers Team Props

Guardians Recent Betting Performance

• The Guardians have played as underdogs in four of their past 10 games and won each of those contests.
• The Guardians and their opponents have combined to hit the over just once in their last 10 games with a total.
• The Guardians have eight wins against the spread in their last 10 chances.

Guardians Recent Stats

Guardians Player Insights

• Jose Ramirez leads the lineup with a batting average of .282, while pacing the Guardians in home runs, with 30 and runs batted in with 81.
• Among all hitters in the majors, Ramirez ranks 21st in home runs and 44th in RBI.
• Ramirez brings a hitting streak of five games into this game. During his last five outings he is hitting .316 with a double, two home runs, two walks and three RBIs.
• Kwan is batting .276 with 28 doubles, a triple, 11 home runs and 54 walks.
• Among all MLB batters, Kwan ranks 186th in homers and 139th in RBI.
• Kyle Manzardo has 17 doubles, two triples, 26 home runs and 48 walks while batting .236.
• Angel Martinez is batting .226 with 23 doubles, two triples, 11 home runs and 22 walks.

Guardians Team Props

Guardians vs. Twins Game 1 Highlights | MLB on FOX

Check out the best moments between the Cleveland Guardians and Minnesota Twins.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

Cleveland Guardians

Detroit Tigers