Tigers vs. Guardians Prediction, Odds, Picks - May 22

Riley Greene and Carlos Santana will look to continue their recent offensive production when the Detroit Tigers and Cleveland Guardians hit the field at Comerica Park on Thursday, at 6:40 p.m. ET. The Tigers are -131 moneyline favorites for this matchup with the Guardians (+111). Detroit is a 1.5-run favorite (at +163 odds). The game's total is set at 8 runs.

Check out everything you need to know from a betting perspective on the Tigers-Guardians game, regarding the run line, moneyline and total, plus expert picks.

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Tigers vs. Cardinals Highlights | MLB on FOX

Check out the top moments from this MLB game between the Detroit Tigers and the St. Louis Cardinals!

Tigers vs. Guardians Game Information & Odds

• When: Thursday, May 22, 2025 at 6:40 p.m. ET
• Where: Comerica Park in Detroit, Michigan
• How to watch on TV: MLB Network, FDSDET, and CLEG

Tigers vs. Guardians Prediction

• Score Prediction: Tigers 6, Guardians 4
• Total Prediction: Over 8 runs
• Win Probabilities: Tigers 58%, Guardians 42%

Tigers vs. Guardians Betting Insights

• The Tigers have been favorites in 29 games this season and won 22 (75.9%) of those contests.
• Detroit has a record of 20-4 in games when sportsbooks favor them by at least -131 on the moneyline.
• The bookmakers' moneyline implies a 56.7% chance of a victory for the Tigers.
• The Guardians have come away with 13 wins in the 27 contests they have been listed as the underdogs in this season.
• This season, Cleveland has come away with a win four times in 13 chances when named as an underdog of at least +111 or worse on the moneyline.
• The moneyline set for this matchup implies the Guardians have a 47.4% chance of coming away with a victory in the contest.

Tigers Recent Betting Performance

• The Tigers have a 4-2 record from the six games they were favored on the moneyline over their last 10 matchups.
• In their last 10 matchups, the Tigers and their opponents combined to go over the run total five times (all 10 of the games had set totals).
• The Tigers have a 4-6-0 record against the spread over their past 10 games.

Tigers Recent Stats

Tigers Player Insights

• Spencer Torkelson has put up a team-best 12 home runs and 39 runs batted in.
• Among all MLB batters, Torkelson is 91st in batting average, 46th in on-base percentage, and 16th in slugging.
• Greene's 12 home runs and .287 batting average both pace his team.
• Greene is ninth in homers and 14th in RBI among all major league hitters this year.
• Greene enters this matchup looking for his fifth game in a row with a hit. During his last five outings he is hitting .368 with two doubles, a home run, two walks and four RBIs.
• Gleyber Torres is batting .281 with six doubles, five home runs and 16 walks.
• Kerry Carpenter is batting .278 with six doubles, a triple, 10 home runs and six walks.

Tigers Team Props

Guardians Recent Betting Performance

• In six games as underdogs over the last 10 matchups, the Guardians have a record of 3-3.
• In their last 10 games with a total, the Guardians and their opponents are 1-8-1 when it comes to hitting the over.
• The Guardians have four wins against the spread in their last 10 chances.

Guardians Recent Stats

Guardians Player Insights

• Jose Ramirez is hitting .304 with 10 doubles, nine home runs and 16 walks, while getting on base at a rate of .363.
• Ramirez ranks 35th in homers and 73rd in RBI among all batters in MLB.
• Ramirez carries a 14-game hitting streak into this matchup. During his last 10 games he is batting .395 with three doubles, three home runs, four walks and six RBIs.
• Steven Kwan is batting .317 to lead the lineup.
• Kwan is 149th overall in home runs and 153rd in RBI this season.
• Santana has three doubles, six home runs and 24 walks while batting .231.
• Kyle Manzardo has put up a team-leading 10 home runs and has driven in 26 runs.

Guardians Team Props

Tigers vs. Cardinals Highlights | MLB on FOX

Check out the top moments from this MLB game between the Detroit Tigers and the St. Louis Cardinals!

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Detroit Tigers

Cleveland Guardians