Reds vs. Marlins Prediction, Odds, Picks - April 22

Otto Lopez will lead the Miami Marlins into a matchup with Gavin Lux and the Cincinnati Reds on Tuesday at 6:40 p.m. ET, in the second game of a three-game series at loanDepot park. The Reds are favored in this one, at -118, while the underdog Marlins have -102 odds to win. Cincinnati is favored on the run line (-1.5 with +139 odds). An 8.5-run over/under is set for the game.

Here's everything you need from a betting perspective on the Reds-Marlins game, regarding the run line, moneyline and total, plus expert picks.

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Reds vs. Marlins Game Information & Odds

• When: Tuesday, April 22, 2025 at 6:40 p.m. ET
• Where: loanDepot park in Miami, Florida
• How to watch on TV: FDSFL and FDSOH

Reds vs. Marlins Prediction

• Score Prediction: Reds 6, Marlins 5
• Total Prediction: Over 8.5 runs
• Win Probabilities: Reds 52%, Marlins 48%

Reds vs. Marlins Betting Insights

• This season, the Reds have been favored eight times and won four of those games.
• This season Cincinnati has won four of its seven games when favored by at least -118 on the moneyline.
• The sportsbooks' moneyline implies a 54.1% chance of a victory for the Reds.
• The Marlins have been underdogs in 20 games this season and have come away with the win eight times (40%) in those contests.
• Miami has a win-loss record of 8-11 when favored by -102 or worse by bookmakers this year.
• The moneyline set for this matchup implies the Marlins have a 50.5% chance of walking away with the win.

Reds Recent Betting Performance

• The Reds have a 3-2 record over the five games they were favored on the moneyline in their last 10 matchups.
• Over their last 10 outings -- all had a set run total -- the Reds and their opponents combined to go over the total six times.
• The Reds have a 6-4-0 record against the spread over their past 10 games.

Reds Recent Stats

Reds Player Insights

• Elly De La Cruz leads the Reds in home runs (five) and runs batted in (22).
• In all of MLB, De La Cruz ranks 25th in home runs and fifth in RBI.
• De La Cruz carries a six-game hitting streak into this matchup. In his last 10 games he is batting .231 with three home runs, six walks and 10 RBI.
• TJ Friedl is batting .294 with three doubles, a triple, a home run and eight walks.
• Friedl is 173rd in homers and 90th in RBI among all hitters in the majors.
• Friedl carries a five-game streak with at least one hit into this matchup. During his last five outings he is hitting .455 with a double, a triple, three walks and four RBI.
• Lux leads the Reds with a team-best batting average of .315.
• Lux will look to build on his seven-game hitting in this game. During his last 10 games he is batting .424 with two doubles, a home run, nine walks and eight RBI.
• Matt McLain has a double, four home runs and 10 walks while batting .212.
• McLain has recorded at least one hit in two straight games. During his last five outings he is hitting .222 with a home run, five walks and four RBI.

Reds Team Props

Marlins Recent Betting Performance

• The Marlins have played as underdogs in nine of their past 10 games and won three of those contests.
• In their last 10 games with a total, the Marlins and their opponents have combined to hit the over nine times.
• The Marlins are 4-6-0 ATS over their last 10 games.

Marlins Recent Stats

Marlins Player Insights

• Lopez is batting .235 with five doubles, two home runs and nine walks, while getting on base at a rate of .311.
• Lopez's home run total puts him 118th in MLB, and he is 116th in RBI.
• Xavier Edwards is batting .286 with three doubles and 12 walks.
• Edwards ranks 272nd among all hitters in the big leagues in home runs, and 161st in RBI.
• Eric Wagaman has four doubles, three home runs and six walks while hitting .277.
• Kyle Stowers has put up a team-high batting average of .306 and leads the Marlins in runs batted in with a mark of 14.

Marlins Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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