Reds vs. Cubs Prediction, Odds, Picks - September 18

Hunter Greene starts for the Cincinnati Reds on Thursday at Great American Ball Park against Nico Hoerner and the Chicago Cubs. First pitch is at 7:15 p.m. ET for the first game of a four-game series. The Reds are favored in this one, at -143, while the underdog Cubs have +120 odds to play spoiler. Cincinnati is favored on the run line (-1.5 with +142 odds). The contest's total is set at 8.5 runs.

Check out everything you need to know from a betting perspective on the Reds-Cubs game, regarding the run line, moneyline and total, plus expert picks.

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Cubs vs. Pirates Highlights | MLB on FOX

Check out the best moments between the Chicago Cubs and Pittsburgh Pirates.

Reds vs. Cubs Game Information & Odds

• When: Thursday, September 18, 2025 at 7:15 p.m. ET
• Where: Great American Ball Park in Cincinnati, Ohio
• How to watch on TV: FOX

Reds vs. Cubs Prediction

• Score Prediction: Reds 5, Cubs 4
• Total Prediction: Over 8.5 runs
• Win Probabilities: Reds 50%, Cubs 50%

Reds vs. Cubs Betting Insights

• This season, the Reds have won 34 out of the 66 games, or 51.5%, in which they've been favored.
• This season Cincinnati has won 10 of its 20 games, or 50%, when favored by at least -143 on the moneyline.
• Sportsbooks have implied with the moneyline set for this matchup that the Reds have a 58.8% chance to win.
• The Cubs have been underdogs in 42 games this season and have come away with the win 18 times (42.9%) in those contests.
• Chicago has a mark of 5-7 in contests where bookmakers favor it by +120 or worse on the moneyline.
• The moneyline set for this matchup implies the Cubs have a 45.5% chance of walking away with the win.

Reds Recent Betting Performance

• The Reds were the moneyline favorite for five of their last 10 games, and finished 2-3 in those matchups.
• Over their last 10 matchups, the Reds and their opponents combined to hit the over on the total three times (all 10 games had set totals).
• The Reds have put together a 5-5-0 record against the spread over their past 10 games.

Reds Recent Stats

Reds Player Insights

• The Reds' best power option comes in the form of Elly De La Cruz and his 19-homer 82-RBI season, both team highs.
• In all of MLB, De La Cruz ranks 81st in home runs and 33rd in RBI.
• TJ Friedl is hitting .259 with 20 doubles, two triples, 12 home runs and 76 walks.
• Friedl ranks 164th in homers in baseball, and 176th in RBI.
• Spencer Steer has 20 doubles, two triples, 18 home runs and 45 walks while batting .242.
• Steer will look to build on his two-game hitting in this game. During his last five outings he is batting .353 with a home run, three walks and five RBIs.
• Austin Hays is batting .266 with 15 doubles, five triples, 15 home runs and 29 walks.
• Hays has recorded at least one hit in two games in a row. During his last five outings he is batting .263 with a walk.

Reds Team Props

Cubs Recent Betting Performance

• The Cubs have played as underdogs in three of their past 10 games and have gone 2-1 in those contests.
• When it comes to hitting the over, the Cubs and their opponents are 4-5-1 in their last 10 games with a total.
• The Cubs are 7-3-0 ATS over their last 10 games.

Cubs Recent Stats

Cubs Player Insights

• Hoerner paces the Cubs with a .303 batting average.
• Hoerner is 270th in home runs and 117th in RBI among all hitters in the majors.
• Hoerner brings a hitting streak of 12 games into this matchup. During his last 10 games he is batting .463 with four doubles, a triple, four walks and three RBIs.
• Pete Crow-Armstrong's 29 home runs lead his team.
• Crow-Armstrong is 22nd in homers and 24th in RBI among all hitters in the majors.
• Ian Happ has 28 doubles, 23 home runs and 85 walks while hitting .243.
• Seiya Suzuki has driven in the most runs for the Cubs with 91 runs batted in.

Cubs Team Props

Cubs vs. Pirates Highlights | MLB on FOX

Check out the best moments between the Chicago Cubs and Pittsburgh Pirates.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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