Red Sox vs. Orioles Prediction, Odds, Picks - August 27

Dietrich Enns gets the nod on the mound for the Baltimore Orioles against the Boston Red Sox and Trevor Story on Wednesday at 6:35 p.m. ET. The Red Sox are listed as -141 moneyline favorites for this matchup with the Orioles (+119). Boston is the favorite on the run line (-1.5 with +115 odds). The over/under is 9 runs for the game (with -101 odds to go over and -121 odds on the under).

Take a look at everything you need to know from a betting perspective on the Red Sox-Orioles game, regarding the run line, moneyline and total, plus expert picks.

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Red Sox vs. Orioles Highlights | MLB on FOX

Check out the best moments between the Boston Red Sox and the Baltimore Orioles.

Red Sox vs. Orioles Game Information & Odds

• When: Wednesday, August 27, 2025 at 6:35 p.m. ET
• Where: Oriole Park at Camden Yards in Baltimore, Maryland
• How to watch on TV: MASN and NESN

Red Sox vs. Orioles Prediction

• Score Prediction: Red Sox 6, Orioles 5
• Total Prediction: Over 9 runs
• Win Probabilities: Red Sox 52%, Orioles 48%

Red Sox vs. Orioles Betting Insights

• This season, the Red Sox have been favored 79 times and won 47, or 59.5%, of those games.
• Boston has a record of 16-15, a 51.6% win rate, when favored by -141 or more by oddsmakers this season.
• The oddsmakers' moneyline implies a 58.5% chance of a victory for the Red Sox.
• The Orioles have been chosen as underdogs in 70 games this year and have walked away with the win 32 times (45.7%) in those games.
• This season, Baltimore has come away with a win 11 times in 27 chances when named as an underdog of at least +119 or longer on the moneyline.
• The Orioles have an implied victory probability of 45.7% according to the moneyline set for this matchup.

Red Sox Recent Betting Performance

• The Red Sox were favored on the moneyline in seven of their last 10 games, and they went 4-3 in those matchups.
• Over their last 10 outings, the Red Sox and their opponents combined to hit the over five times (all 10 of the games had set totals).
• The Red Sox's ATS record is 5-5-0 over their past 10 games.

Red Sox Recent Stats

Red Sox Player Insights

• Jarren Duran is great at both finding his way aboard and doing damage when he's at the plate. Duran leads the Red Sox this season with a .333 OBP, .444 slugging percentage, and 132 hits.
• In all of the majors, Duran is 134th in homers and 36th in RBI.
• Story has 83 runs batted in while hitting .260. Both are team-highs.
• Story ranks 47th in home runs and 16th in RBI among all batters in baseball.
• Alex Bregman is hitting .301 with 24 doubles, 16 home runs and 39 walks.
• Ceddanne Rafaela is batting .247 with 28 doubles, three triples, 14 home runs and 22 walks.

Red Sox Team Props

Orioles Recent Betting Performance

• In seven games as underdogs over the last 10 matchups, the Orioles have a record of 3-4.
• When it comes to hitting the over, the Orioles and their opponents are 6-4-0 in their last 10 games with a total.
• The Orioles have won five of their last 10 games against the spread.

Orioles Recent Stats

Orioles Player Insights

• Gunnar Henderson paces the Orioles with 16 home runs and 59 runs batted in, while posting a team-best batting average of .281.
• Among all hitters in MLB, Henderson is 92nd in home runs and 83rd in RBI.
• Jackson Holliday is hitting .242 with 17 doubles, two triples, 15 home runs and 38 walks.
• Holliday is currently 107th in homers and 132nd in RBI in the major leagues.
• Colton Cowser has 11 doubles, 12 home runs and 16 walks while batting .226.
• Ryan Mountcastle is hitting .255 with 14 doubles, four home runs and 11 walks.

Orioles Team Props

Red Sox vs. Orioles Highlights | MLB on FOX

Check out the best moments between the Boston Red Sox and the Baltimore Orioles.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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