Red Sox vs. Cardinals Prediction, Odds, Picks - April 6

Alex Bregman and Brendan Donovan will be among the star attractions when the Boston Red Sox play the St. Louis Cardinals on Sunday at 7:10 p.m. ET, at Fenway Park. The Cardinals are -101 moneyline underdogs in this matchup with the favorite Red Sox (-119). Boston is a 1.5-run favorite (at +165 odds). The total for the matchup is set at 9 runs.

Check out everything you need from a betting perspective on the Red Sox-Cardinals game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

Cardinals vs. Red Sox Baseball | MLB on FOX

Check out the top highlights between the St. Louis Cardinals and the Boston Red Sox.

Red Sox vs. Cardinals Game Information & Odds

• When: Sunday, April 6, 2025 at 7:10 p.m. ET
• Where: Fenway Park in Boston, Massachusetts
• How to watch on TV: ESPN

Red Sox vs. Cardinals Prediction

• Score Prediction: Red Sox 6, Cardinals 5
• Total Prediction: Over 9 runs
• Win Probabilities: Red Sox 56%, Cardinals 44%

Red Sox vs. Cardinals Betting Insights

• This season, the Red Sox have been favored five times and won four of those games.
• Boston has been at least -119 moneyline favorites three times this season and won each of those games.
• Sportsbooks have implied with the moneyline set for this matchup that the Red Sox have a 54.3% chance to win.
• The Cardinals have come away with three wins in the five contests they have been listed as the underdogs in this season.
• St. Louis has yet to play a game this season with longer moneyline odds than -101.
• The moneyline set for this matchup implies the Cardinals have a 50.2% chance of coming away with a victory in the contest.

Red Sox Player Insights

• Wilyer Abreu paces the Red Sox with three home runs and nine runs batted in, while racking up a team-best batting average of .522.
• In all of the majors, Abreu is 16th in home runs and 15th in RBI.
• Abreu brings a hitting streak of three games into this game. In his last five games he is hitting .385 with a home run, three walks and three RBI.
• Kristian Campbell has four doubles, two home runs and seven walks while hitting .379.
• Campbell is 40th in home runs and 66th in RBI among all MLB hitters this season.
• Bregman has three doubles, a home run and three walks while hitting .282.
• Trevor Story has two home runs and two walks while batting .250.
• Story has recorded at least one hit in two games in a row. In his last five games he is batting .333 with two home runs, a walk and four RBI.

Red Sox Team Props

Cardinals Player Insights

• Ivan Herrera leads the Cardinals in home runs (four) and runs batted in (11).
• Herrera ranks fifth in home runs and sixth in RBI among all batters in the majors.
• Lars Nootbaar's .353 batting average is a team-high mark.
• Nootbaar ranks 40th among all hitters in the big leagues in homers, and 43rd in RBI.
• Nolan Arenado is batting .333 with three doubles, a home run and five walks.
• Victor Scott II has a double, a home run and five walks while batting .310.

Cardinals Team Props

Cardinals vs. Red Sox Baseball | MLB on FOX

Check out the top highlights between the St. Louis Cardinals and the Boston Red Sox.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

Boston Red Sox

St. Louis Cardinals