Rays vs. Guardians Prediction, Odds, Picks - September 6

Shane Baz is starting for the Tampa Bay Rays on Saturday against Kyle Manzardo and the Cleveland Guardians. First pitch is at 7:05 p.m. ET at George M. Steinbrenner Field. The favored Rays have -140 moneyline odds against the underdog Guardians, who are listed at +118. Tampa Bay is the run-line favorite (-1.5). The over/under is 8 runs for the contest (with -114 odds on the over and -106 odds on the under).

Here's everything you need from a betting perspective on the Rays-Guardians game, regarding the run line, moneyline and total, plus expert picks.

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Guardians vs. Rays Highlights | MLB on FOX

Check out the best highlights between the Cleveland Guardians and the Tampa Bay Rays.

Rays vs. Guardians Game Information & Odds

• When: Saturday, September 6, 2025 at 7:05 p.m. ET
• Where: George M. Steinbrenner Field in Tampa, Florida
• How to watch on TV: FDSSUN and CLEG

Rays vs. Guardians Prediction

• Score Prediction: Rays 5, Guardians 4
• Total Prediction: Over 8 runs
• Win Probabilities: Rays 56%, Guardians 44%

Rays vs. Guardians Betting Insights

• The Rays have entered the game as favorites 70 times this season and won 42, or 60%, of those games.
• Tampa Bay is 20-16 this season when entering a game favored by -140 or more on the moneyline.
• Oddsmakers have implied with the moneyline set for this matchup that the Rays have a 58.3% chance to win.
• The Guardians have been underdogs in 80 games this season and have come away with the win 35 times (43.8%) in those contests.
• Cleveland has a win-loss record of 19-18 when favored by +118 or worse by sportsbooks this year.
• The Guardians have an implied victory probability of 45.9% according to the moneyline set for this matchup.

Rays Recent Betting Performance

• The Rays went 5-2 across the seven games they were favored on the moneyline in their last 10 matchups.
• Over their last 10 outings (all had set totals), the Rays combined with their opponents to go over the total five times.
• The Rays' ATS record is 7-3-0 over their past 10 games.

Rays Recent Stats

Rays Player Insights

• Junior Caminero is the Rays best power hitter, connecting on 41 long balls this season in addition to delivering 103 RBI, both team highs.
• Among all MLB hitters, Caminero ranks 63rd in batting average, 125th in on-base percentage, and ninth in slugging.
• Caminero carries a five-game hitting streak into this matchup. During his last five outings he is batting .476 with three doubles, two home runs and nine RBIs.
• Yandy Diaz has a club-high .293 batting average.
• Diaz ranks 49th in homers and 43rd in RBI among all MLB hitters this year.
• Brandon Lowe is hitting .262 with 15 doubles, 28 home runs and 35 walks.
• Chandler Simpson is batting .290 with 11 doubles, three triples and 18 walks.

Rays Team Props

Guardians Recent Betting Performance

• The Guardians have played as underdogs in nine of their past 10 games and won five of those contests.
• In their last 10 games with a total, the Guardians and their opponents have combined to hit the over four times.
• The Guardians have won six of their last 10 games against the spread.

Guardians Recent Stats

Guardians Player Insights

• Jose Ramirez leads the lineup with a batting average of .283, and paces the Guardians in home runs, with 27 and runs batted in with 73.
• Among all hitters in the majors, Ramirez is 25th in homers and 48th in RBI.
• Steven Kwan is batting .274 with 25 doubles, a triple, 10 home runs and 46 walks.
• Kwan ranks 184th overall in home runs and 167th in RBI this season.
• Manzardo has 14 doubles, two triples, 25 home runs and 43 walks while batting .235.
• Angel Martinez is batting .225 with 21 doubles, a triple, 10 home runs and 17 walks.

Guardians Team Props

Guardians vs. Rays Highlights | MLB on FOX

Check out the best highlights between the Cleveland Guardians and the Tampa Bay Rays.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Tampa Bay Rays

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